Use of phosphodiesterase iv inhibitors

ABSTRACT

Use of phosphodiesterase IV inhibitors and/or physiologically acceptable salts thereof for the preparation of a medicament for the treatment of osteoporosis, tumours, tumour metastases, atherosclerosis, rheumatoid arthritis, multiple sclerosis, diabetes mellitus, ulcerative collitis and AIDS.

[0001] The invention relates to the use of

[0002] a) compounds of the formula I, disclosed in EP 0 738 715 A2,

[0003] in which

[0004] R¹ and R² are each, independently of one another, H or A,

[0005] R³ and R⁴ are each, independently of one another, —OH, —OR¹⁰, —S—R¹⁰, —SO—R¹⁰, —SO₂—R¹⁰, Hal, methylenedioxy, —NO₂, —NH₂, —NHR¹⁰ or —NR¹⁰R¹¹,

[0006] R⁵ is a phenyl radical which is unsubstituted or monosubstituted or disubstituted by R⁶ and/or R⁷,

[0007] Q is absent or is alkylene having 1-6 carbon atoms,

[0008] R⁶ and R⁷ are each, independently of one another, —NH₂, —NR⁸R⁹, —NHR¹⁰, —NR¹⁰R¹¹, —NO₂, Hal, —CN, —OA, —COOH or —COOA,

[0009] R⁸ and R⁹ are each, independently of one another, H, acyl having 1-8 carbon atoms, which may be substituted by 1-5 F and/or Cl atoms, or —COOA, —SO-A, —SO₂A, —CONH₂, —CONHA, —CONA₂, —CO—COOH, —CO—COOA, —CO—CONH₂, —CO—CONHA or —CO—CONA₂,

[0010] A is alkyl having from 1 to 6 carbon atoms, which may be substituted by 1-5 F and/or Cl atoms,

[0011] R¹⁰ and R¹¹ are each, independently of one another, A, cycloalkyl having 3-7 carbon atoms, methylenecycloalkyl having 4-8 carbon atoms or alkenyl having 2-8 carbon atoms,

[0012] and

[0013] Hal is F, Cl, Br or l,

[0014] b) compounds of the formula I, disclosed in EP 0 723 962 B1,

[0015] in which

[0016] R¹ and R² are each, independently of one another, H or A,

[0017] R³ and R⁴ are each, independently of one another, —OH, —OR¹⁰, —S—R¹⁰, —SO—R¹⁰, —SO₂—R¹⁰, Hal, methylenedioxy, —NO₂, —NH₂, —NHR¹⁰ or —NR¹⁰R¹¹,

[0018] R⁵ is a phenyl radical which is unsubstituted or monosubstituted or disubstituted by R⁶ and/or R⁷,

[0019] Q is absent or is alkylene having 1-6 carbon atoms,

[0020] R⁶ and R⁷ are each, independently of one another, —NH₂, —NR⁸R⁹, —NHR¹⁰, —NR¹⁰R¹¹, —NO₂, Hal, —CN, —OA, —COOH or —COOA,

[0021] R⁸ and R⁹ are each, independently of one another, H, acyl having 1-8 carbon atoms, which may be substituted by 1-5 F and/or Cl atoms, or —COOA, —SO-A, —SO₂A, —CONH₂, —CONHA, —CONA₂, —CO—COOH, —CO—COOA, —CO—CONH₂, —CO—CONHA or —CO—CONA₂,

[0022] A is alkyl having from 1 to 6 carbon atoms, which may be substituted by 1-5 F and/or Cl atoms,

[0023] R¹⁰ and R¹¹ are each, independently of one another, A, cycloalkyl having 3-7 carbon atoms, methylenecycloalkyl having 4-8 carbon atoms or alkenyl having 2-8 carbon atoms,

[0024] and

[0025] Hal is F, Cl, Br or l,

[0026] c) compounds of the formula I, disclosed in EP 0 763 534 A1,

[0027] in which

[0028] B is an aromatic heterocyclic radical having from 1 to 4 N, O and/or S atoms, bonded via N or C, which may be unsubstituted or monosubstituted, disubstituted or trisubstituted by Hal, A and/or OA, and may also be fused to a benzene or pyridine ring,

[0029] Q is absent or is alkylene having 1-6 carbon atoms,

[0030] X is CH₂, S or O,

[0031] R¹ and R² are each, independently of one another, H or A,

[0032] R³ and R⁴ are each, independently of one another, —OH, —OR⁵, —S—R⁵, —SO—R⁵, —SO₂—R⁵, Hal, methylenedioxy, —NO₂, —NH₂, —NHR⁵ or —NR⁵R⁶,

[0033] R⁵ and R⁶ are each, independently of one another, A, cycloalkyl having 3-7 carbon atoms, methylenecycloalkyl having 4-8 carbon atoms or alkenyl having 2-8 carbon atoms,

[0034] A is alkyl having from 1 to 10 carbon atoms, which may be substituted by from 1 to 5 F and/or Cl atoms, and

[0035] Hal is F, Cl, Br or l,

[0036] d) compounds of the formula I, disclosed in EP 0 539 806 B1,

[0037] in which

[0038] R¹ and R² are each, independently of one another, H or A,

[0039] R³ is H, OA or O—C_(m)H_(2m+1−n)X_(n),

[0040] R⁴ is —O—C_(m)H_(2m+1−n)X_(n),

[0041] X is F or Cl,

[0042] A is alkyl having 1-6 carbon atoms,

[0043] m is 1, 2, 3, 4, 5 or 6, and

[0044] n is 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12 or 13,

[0045] e) compounds of the formula I, disclosed in EP 0 618 201 A1,

[0046] in which

[0047] R¹ and R² are each, independently of one another, H or A,

[0048] R³ and R⁴ are each, independently of one another, OH, OA, SA, SOA, SO₂A, Hal, methylenedioxy, cycloalkoxy having 3-7 carbon atoms or O—C_(m)H_(2m+1−k)F_(k),

[0049] R⁵ is —NR⁶R⁷ or

[0050] where one CH₂ group may also be replaced by oxygen,

[0051] R⁶ and R⁷ are each, independently of one another, H or A,

[0052] Q is alkylene having 1-6 carbon atoms,

[0053] A is alkyl having 1-6 carbon atoms,

[0054] Hal is F, Cl, Br or l,

[0055] m is 1, 2, 3, 4, 5 or 6,

[0056] n is 3, 4, 5 or 6,

[0057] k is 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12 or 13,

[0058] f) compounds of the formula I, disclosed in DE 196 04 388 A1,

[0059] in which

[0060] R¹ and R² are each, independently of one another, H or A,

[0061] R³ and R⁴ are each, independently of one another, —OH, —OA, —S—A, —SO—A, —SO₂-A, Hal, methylenedioxy, —NO₂, —NH₂, —NHA or —NAA′,

[0062] A and A′ are each, independently of one another, alkyl having from 1 to 10 carbon atoms, which may be substituted by from 1 to 5 F and/or Cl atoms, or cycloalkyl having 3-7 carbon atoms or methylenecycloalkyl having 4-8 carbon atoms,

[0063] B is —Y—R⁵ or —O—Y—R⁵,

[0064] Q is absent or is alkylene having 1-4 carbon atoms,

[0065] Y is absent or is alkylene having 1 -10 carbon atoms,

[0066] X is CH₂ or S,

[0067] R⁵ is NH₂, NHA, NAA′ or a saturated 3-8-membered heterocyclic radical having at least one N atom which is unsubstituted or monosubstituted by A or OH and in which, in addition, further CH₂ groups may be replaced by NH, NA, S or O,

[0068] Hal is F, Cl, Br or l,

[0069] and/or physiologically acceptable salts thereof for the preparation of a medicament for the treatment of osteoporosis, tumours, tumour metastases, atherosclerosis, rheumatoid arthritis, multiple sclerosis, diabetes mellitus, ulcerative colitis and AIDS.

[0070] The invention had the object of finding novel uses of the compounds of the formulae I, in particular those which can lead to the preparation of medicaments.

[0071] It has been found that the compounds of the formulae I and their salts have very valuable pharmacological properties and are well tolerated.

[0072] In particular, they exhibit selective phosphodiesterase IV inhibition combined with an intracellular increase in cAMP (N. Sommer et al., Nature Medicine, 1, 244-248 (1995)).

[0073] The PDE IV inhibition can be demonstrated, for example, analogously to C. W. Davis in Biochim. Biophys. Acta 797, 354-362 (1984).

[0074] The compounds according to the invention can be employed for the treatment of asthmatic diseases. The antiasthmatic action of PDE IV inhibitors has been described, for example, by T. J. Torphy et al. in Thorax, 46, 512-523 (1991) and can be determined, for example, by the method of T. Olsson, Acta allergologica 26, 438-447 (1971).

[0075] Since cAMP inhibits bone-degrading cells and stimulates bone-forming cells (S. Kasugai et al., M 681 and K. Miyamoto, M 682, in Abstracts of the American Society for Bone and Mineral Research, 18^(th) Annual Meeting, 1996), the compounds according to the invention can be employed for the treatment of osteoporosis.

[0076] In addition, the compounds exhibit an inhibiting action to the formation of TNF (tumour necrosis factor) and are therefore suitable for the treatment of allergic and inflammatory illnesses, autoimmune diseases and transplant rejection reactions. They can be employed for the treatment of memory disorders, tumours, tumour metastases, atherosclerosis, rheumatoid arthritis, multiple sclerosis, Crohn's disease, atopic dermatitis, diabetes mellitus, ulcerative colitis and AIDS.

[0077] The action of PDE IV inhibitors in the treatment of asthma, inflammatory diseases, diabetes mellitus, atopic dermatitis, psoriasis, AIDS, tumour growth or tumour metastases is described, for example in EP 779 291.

[0078] The antiinflammatory action of the substances according to the invention and their efficacy for the treatment of, for example, autoimmune diseases, multiple sclerosis or rheumatoid arthritis, can be determined analogously to the methods of N. Sommer et al., Nature Medicine 1, 244-248 (1995) or L. Sekut et al., Clin. Exp. Immunol. 100, 126-132 (1995).

[0079] The action of PDE IV inhibitors in the treatment of tumours is described, for example, in WO 95/35281, WO 95/17399 and WO 96/00215.

[0080] Surprisingly, it has been found that the compounds of the formula I are suitable for the treatment of cancer.

[0081] The invention furthermore relates to the use of the compounds of the formulae I and their physiologically acceptable salts and/or solvates for the preparation of a medicament for inhibiting the growth of neoplastic cells.

[0082] The term neoplastic cells is taken to mean cancer cells.

[0083] The invention relates in particular to the use of the compounds of the formulae I and their physiologically acceptable salts and/or solvates for the preparation of a medicament for the treatment and/or prophylaxis of cancer diseases.

[0084] The invention furthermore relates to the use of the compounds of the formulae I and their physiologically acceptable salts and/or solvates for the preparation of a medicament for the treatment of neoplastic damage.

[0085] The invention furthermore relates to the use of the compounds of the formulae I and their physiologically acceptable salts and/or solvates for the preparation of a medicament for the treatment of pre-cancerogenic damage.

[0086] The term precancerogenic damage is taken to mean, for example, benign tumours in the intestine which could lead to intestinal cancer.

[0087] The term precancerogenic damage is taken to mean, in particular, the lesions mentioned in U.S. Pat. No. 5,948,911 in column 4, lines 49-60.

[0088] Irregularities in apoptosis (cell death) play a part in the formation of precancerogenic damage.

[0089] It is also known that the regulation of apoptosis plays an important role in diseases connected with abnormal cell growth, such as, for example, benign prostate hyperplasia, neurodegenerative diseases, such as, for example, Parkinson's, autoimmune diseases, including multiple sclerosis, and rheumatoid arthritis, or infection diseases, such as AIDS.

[0090] The compounds of the formulae I modulate apoptosis and are used in the treatment or prophylaxis of cancer diseases.

[0091] The invention thus relates to the use of the compounds of the formulae I and their physiologically acceptable salts and/or solvates for the preparation of a medicament for the regulation of apoptosis in human cells.

[0092] The compounds of the formulae I can be employed as medicament active ingredients in human and veterinary medicine. They can furthermore be employed as intermediates for the preparation of further medicament active ingredients.

[0093] The compounds of the formulae I can have a chiral centre and can therefore occur in a plurality of stereoisomeric forms. All these forms (for example R and S forms) and mixtures thereof (for example the R,S forms) are included in the formulae I.

[0094] These compounds of the formulae I can be used as medicaments in human or veterinary medicine. Suitable excipients are organic or inorganic substances which are suitable for enteral (for example oral), parenteral or topical administration and do no react with the novel compounds, for example water, vegetable oils, benzyl alcohols, alkylene glycols, polyethylene glycols, glycerol triacetate, gelatine, carbohydrates, such as lactose or starch, magnesium stearates, talc or vaseline. Suitable for oral administration are, in particular, tablets, pills, coated tablets, capsules, powders, granules, syrups, juices or drops, suitable for rectal administration are suppositories, suitable for parenteral administration are solutions, preferably oil-based or aqueous solutions, furthermore suspensions, emulsions or implants, and suitable for topical application are ointments, creams or powders. The novel compounds may also be lyophilised and the resultant lyophilisates used, for example, for the preparation of injection preparations. The preparations indicated may be sterilised and/or comprise assistants, such as lubricants, preservatives, stabilisers and/or wefting agents, emulsifiers, salts for modifying the osmotic pressure, buffer substances, colorants and flavours and/or one or more further active ingredients, for example one or more vitamins.

[0095] The compounds of the formulae I and their physiologically acceptable salts can be employed for combating illnesses in which an increase in the cAMP (cycloadenosine monophosphate) level results in inflammation inhibition or prevention and muscle relaxation.

[0096] The compounds according to the invention can be used, in particular, in the treatment osteoporosis, tumours, tumour metastases, asthma, chronic bronchitis, atopic dermatitis, psoriasis and skin diseases and autoimmune diseases.

[0097] The substances according to the invention are in general preferably administered in doses of between about 1 and 500 mg, in particular between 5 and 100 mg per dosage unit. The daily dose is preferably between about 0.02 and 10 mg/kg of body weight. However, the specific dose for each patient depends on a wide variety of factors, for example on the efficacy of the specific compound employed, on the age, body weight, general state of health, sex, on the diet, on the time and method of administration, on the excretion rate, medicament combination and severity of the particular illness to which the therapy applies. Oral administration is preferred.

[0098] Compounds of the formulae I can have one or more centres of asymmetry. In this case, they are usually in racemic form. Racemates obtained can be separated into their enantiomers mechanically or chemically by methods known per se. Diastereomers are preferably formed from the racemic mixtures by reaction with an optically active resolving agent.

[0099] The invention relates, in particular, to the use of

[0100] a) compounds, disclosed in EP 0 738 715 A2, selected from the group consisting of

[0101] 2-(4-nitrobenzyl)-6-(3,4-dimethoxyphenyl)-2,3,4,5-tetrahydropyridazin-3-one, m.p. 126°;

[0102] 2-(3-nitrobenzyl)-6-(3,4-dimethoxyphenyl)-2,3,4,5-tetrahydropyridazin-3-one, m.p. 122°;

[0103] 2-(2-nitrobenzyl)-6-(3,4-dimethoxyphenyl)-2,3,4,5-tetrahydropyridazin-3-one;

[0104] 2-(2,3-dinitrobenzyl)-6-(3,4-dimethoxyphenyl)-2,3,4,5-tetrahydropyridazin-3-one;

[0105] 2-(2,4-dinitrobenzyl)-6-(3,4-dimethoxyphenyl)-2,3,4,5-tetrahydropyridazin-3-one;

[0106] 2-(2-methoxybenzyl)-6-(3,4-dimethoxyphenyl)-2,3,4,5-tetrahydropyridazin-3-one;

[0107] 2-(4-methoxybenzyl)-6-(3,4-dimethoxyphenyl )-2,3,4,5-tetrahydropyridazin-3-one;

[0108] 2-(2-chlorobenzyl)-6-(3,4-dimethoxyphenyl)-2,3,4,5-tetrahydropyridazin-3-one;

[0109] 2-(2,6-dichlorobenzyl)-6-(3,4-dimethoxyphenyl)-2,3,4,5-tetrahydropyridazin-3-one;

[0110] 2-(4-cyanobenzyl)-6-(3,4-dimethoxyphenyl)-2,3,4,5-tetrahydropyridazin-3-one;

[0111] 2-(4-carboxybenzyl)-6-(3,4-dimethoxyphenyl)-2,3,4,5-tetrahydropyridazin-3-one;

[0112] 2-(4-nitrobenzyl)-6-(3,4-dimethoxyphenyl)-5-ethyl-2,3,4,5-tetrahydropyridazin-3-one;

[0113] 2-(3-nitrobenzyl)-6-(3,4-dimethoxyphenyl)-5-ethyl-2,3,4,5-tetrahydropyridazin-3-one;

[0114] 2-(2-nitrobenzyl)-6-(3,4-dimethoxyphenyl)-5-ethyl-2,3,4,5-tetrahydropyridazin-3-one;

[0115] 2-(2,3-dinitrobenzyl)-6-(3,4-dimethoxyphenyl)-5-ethyl-2,3,4,5-tetrahydropyridazin-3-one;

[0116] 2-(2,4-dinitrobenzyl)-6-(3,4-dimethoxyphenyl)-5-ethyl-2,3,4,5-tetrahydropyridazin-3-one;

[0117] 2-(2-methoxybenzyl)-6-(3,4-dimethoxyphenyl)-5-ethyl-2,3,4,5-tetrahydropyridazin-3-one;

[0118] 2-(4-methoxybenzyl)-6-(3,4-dimethoxyphenyl)-5-ethyl-2,3,4,5-tetrahydropyridazin-3-one;

[0119] 2-(2-chlorobenzyl)-6-(3,4-dimethoxyphenyl)-5-ethyl-2,3,4,5-tetrahydropyridazin-3-one;

[0120] 2-(2,6-dichlorobenzyl)-6-(3,4-dimethoxyphenyl)-5-ethyl-2,3,4,5-tetrahydropyridazin-3-one;

[0121] 2-(4-cyanobenzyl)-6-(3,4-dimethoxyphenyl)-5-ethyl-2,3,4,5-tetrahydropyridazin-3-one;

[0122] 2-(4-carboxybenzyl)-6-(3,4-dimethoxyphenyl)-5-ethyl-2,3,4,5-tetrahydropyridazin-3-one;

[0123] 2-(4-nitrobenzyl)-6-(3-methoxy-4-trifluoromethoxyphenyl)-5-ethyl-2,3,4,5-tetrahydropyridazin-3-one;

[0124] 2-(4-nitrobenzyl)-6-(3-methoxy-4-difluoromethoxyphenyl)-5-ethyl-2,3,4,5-tetrahydropyridazin-3-one;

[0125] 2-(4-nitrobenzyl)-6-(3-methoxy-4-fluoromethoxyphenyl)-5-ethyl-2,3,4,5-tetrahydropyridazin-3-one;

[0126] 2-(4-nitrobenzyl)-6-(3-difluoromethoxy-4-methoxyphenyl)-5-ethyl-2,3,4,5-tetrahydropyridazin-3-one;

[0127] 2-(4-nitrobenzyl)-6-(3-trifluoromethoxy-4-methoxyphenyl)-5-ethyl-2,3,4,5-tetrahydropyridazin-3-one;

[0128] 2-(4-nitrobenzyl)-6-(3-fluoromethoxy-4-methoxyphenyl)-5-ethyl-2,3,4,5-tetrahydropyridazin-3-one;

[0129] 2-(4-nitrobenzyl)-6-(3-methoxy-4-ethoxyphenyl)-5-ethyl-2,3,4,5-tetrahydropyridazin-3-one;

[0130] 2-(4-nitrobenzyl)-6-(3-ethoxy-4-methoxyphenyl)-5-ethyl-2,3,4,5-tetrahydropyridazin-3-one;

[0131] 2-(4-nitrobenzyl)-6-(3-hydroxy-4-methoxyphenyl)-5-ethyl-2,3,4,5-tetrahydropyridazin-3-one;

[0132] 2-(4-nitrobenzyl)-6-(4-methylsulfonylphenyl)-5-ethyl-2,3,4,5-tetrahydropyridazin-3-one;

[0133] 2-(4-nitrobenzyl)-6-(4-methyleneoxyphenyl)-5-ethyl-2,3,4,5-tetrahydropyridazin-3-one;

[0134] 2-(4-nitrobenzyl)-6-(3-cyclopentyloxy-4-methoxyphenyl)-5-ethyl-2,3,4,5-tetrahydropyridazin-3-one;

[0135] 2-(4-aminobenzyl)-6-(3,4-dimethoxyphenyl)-2,3,4,5-tetrahydropyridazin-3-one, m.p. 184°;

[0136] 2-(3-aminobenzyl)-6-(3,4-dimethoxyphenyl)-2,3,4,5-tetrahydropyridazin-3-one, m.p. 140°;

[0137] 2-(2-aminobenzyl)-6-(3,4-dimethoxyphenyl)-2,3,4,5-tetrahydropyridazin-3-one;

[0138] 2-(2,3-diaminobenzyl)-6-(3,4-dimethoxyphenyl)-2,3,4,5-tetrahydropyridazin-3-one;

[0139] 2-(2,4-diaminobenzyl)-6-(3,4-dimethoxyphenyl)-2,3,4,5-tetrahydropyridazin-3-one;

[0140] 2-(4-aminobenzyl)-6-(3,4-dimethoxyphenyl)-5-ethyl-2,3,4,5-tetrahydropyridazin-3-one;

[0141] 2-(3-aminobenzyl)-6-(3,4-dimethoxyphenyl)-5-ethyl-2,3,4,5-tetrahydropyridazin-3-one, m.p. 49°;

[0142] 2-(2-aminobenzyl)-6-(3,4-dimethoxyphenyl)-5-ethyl-2,3,4,5-tetrahydropyridazin-3-one;

[0143] 2-(2,3-diaminobenzyl)-6-(3,4-dimethoxyphenyl)-5-ethyl-2,3,4,5-tetrahydropyridazin-3-one;

[0144] 2-(2,4-diaminobenzyl)-6-(3,4-dimethoxyphenyl)-5-ethyl-2,3,4,5-tetrahydropyridazin-3-one;

[0145] 2-(4-aminobenzyl)-6-(3-methoxy-4-trifluoromethoxyphenyl)-5-ethyl-2,3,4,5-tetrahydropyridazin-3-one;

[0146] 2-(4-aminobenzyl)-6-(3-methoxy-4-difluoromethoxyphenyl)-5-ethyl-2,3,4,5-tetrahydropyridazin-3-one;

[0147] 2-(4-aminobenzyl)-6-(3-methoxy-4-fluoromethoxyphenyl)-5-ethyl-2,3,4,5-tetrahydropyridazin-3-one;

[0148] 2-(4-aminobenzyl)-6-(3-difluoromethoxy-4-methoxyphenyl)-5-ethyl-2,3,4,5-tetrahydropyridazin-3-one;

[0149] 2-(4-aminobenzyl)-6-(3-trifluoromethoxy-4-methoxyphenyl)-5-ethyl-2,3,4,5-tetrahydropyridazin-3-one;

[0150] 2-(4-aminobenzyl)-6-(3-fluoromethoxy-4-methoxyphenyl)-5-ethyl-2,3,4,5-tetrahydropyridazin-3-one;

[0151] 2-(4-aminobenzyl)-6-(3-methoxy-4-ethoxyphenyl)-5-ethyl-2,3,4,5-tetrahydropyridazin-3-one;

[0152] 2-(4-aminobenzyl)-6-(3-ethoxy-4-methoxyphenyl )-5-ethyl-2,3,4,5-tetrahydropyridazin-3-one;

[0153] 2-(4-aminobenzyl)-6-(3-hydroxy-4-methoxyphenyl)-5-ethyl-2,3,4,5-tetrahydropyridazin-3-one;

[0154] 2-(4-aminobenzyl)-6-(4-methylsulfonylphenyl)-5-ethyl-2,3,4,5-tetrahydropyridazin-3-one;

[0155] 2-(4-aminobenzyl)-6-(4-methyleneoxyphenyl)-5-ethyl-2,3,4,5-tetrahydropyridazin-3-one;

[0156] 2-(4-aminobenzyl)-6-(3-cyclopentyloxy-4-methoxyphenyl)-5-ethyl-2,3,4,5-tetrahydropyridazin-3-one;

[0157] 2-(3-aminobenzyl)-6-(3-cyclopentyloxy-4-methoxyphenyl)-5-ethyl-2,3,4,5-tetrahydropyridazin-3-one, m.p. 109°;

[0158] 2-(4-aminophenethyl)-6-(3,4-dimethoxyphenyl)-2,3,4,5-tetrahydropyridazin-3-one;

[0159] 2-(4-aminophenethyl)-6-(3,4-dimethoxyphenyl)-5-ethyl-2,3,4,5-tetrahydropyridazin-3-one;

[0160] 2-(3-aminobenzyl)-6-(3-ethoxy-4-methoxyphenyl)-2,3,4,5-tetrahydropyridazin-3-one, m.p. 112°;

[0161] 2-(4-carboxybenzyl)-6-(3,4-dihydroxyphenyl )-5-ethyl-2,3,4,5-tetrahydropyridazin-3-one;

[0162] 2-(4-butyrylaminobenzyl)-6-(3,4-dimethoxyphenyl)-2,3,4,5-tetrahydropyridazin-3-one, m.p. 148°;

[0163] 2-(4-acetamidobenzyl)-6-(3,4-dimethoxyphenyl)-2,3,4,5-tetrahydropyridazin-3-one, m.p. 183°;

[0164] 2-(4-trifluoroacetamidobenzyl)-6-(3,4-dimethoxyphenyl)-2,3,4,5-tetrahydropyridazin-3-one, m.p. 210°;

[0165] 2-(4-methylsulfonamidobenzyl)-6-(3,4-dimethoxyphenyl)-2,3,4,5-tetrahydropyridazin-3-one, m.p. 138°;

[0166] 2-(4-propionylaminobenzyl)-6-(3,4-dimethoxyphenyl)-2,3,4,5-tetrahydropyridazin-3-one, m.p. 176°;

[0167] 2-(4-tert-butylcarbonylaminobenzyl)-6-(3,4-dimethoxyphenyl)-2,3,4,5-tetrahydropyridazin-3-one, m.p. 155°;

[0168] 2-(4-isobutyrylaminobenzyl)-6-(3,4-dimethoxyphenyl)-2,3,4,5-tetrahydropyridazin-3-one;

[0169] 2-(4-methoxycarbonylaminobenzyl)-6-(3,4-dimethoxyphenyl)-2,3,4,5-tetrahydropyridazin-3-one;

[0170] 2-(4-pivalylaminobenzyl)-6-(3,4-dimethoxyphenyl)-2,3,4,5-tetrahydropyridazin-3-one;

[0171] 2-(4-cyclopentylcarbamoylbenzyl)-6-(3,4-dimethoxyphenyl)-2,3,4,5-tetrahydropyridazin-3-one;

[0172] 2-(4-ethoxycarbonylaminobenzyl)-6-(3,4-dimethoxyphenyl)-2,3,4,5-tetrahydropyridazin-3-one, m.p. 147°;

[0173] 2-(4-methoxalylaminobenzyl)-6-(3,4-dimethoxyphenyl)-2,3,4,5-tetrahydropyridazin-3-one;

[0174] 2-(4-ureidobenzyl)-6-(3,4-dimethoxyphenyl)-2,3,4,5-tetrahydropyridazin-3-one;

[0175] 2-(4-pentanoylaminobenzyl)-6-(3,4-dimethoxyphenyl)-2,3,4,5-tetrahydropyridazin-3-one;

[0176] 2-(4-hexanoylaminobenzyl)-6-(3,4-dimethoxyphenyl)-2,3,4,5-tetrahydropyridazin-3-one;

[0177] 2-(4-pentafluoropropionylaminobenzyl)-6-(3,4-dimethoxyphenyl)-2,3,4,5-tetrahydropyridazin-3-one;

[0178] 2-(4-acetamidobenzyl)-6-(3,4-dimethoxyphenyl)-5-ethyl-2,3,4,5-tetrahydropyridazin-3-one;

[0179] 2-(4-trifluoroacetamidobenzyl)-6-(3,4-dimethoxyphenyl)-5-ethyl-2,3,4,5-tetrahydropyridazin-3-one, m.p. 133°;

[0180] 2-(4-methylsulfonamidobenzyl)-6-(3,4-dimethoxyphenyl)-5-ethyl-2,3,4,5-tetrahydropyridazin-3-one;

[0181] 2-(4-propionylaminobenzyl)-6-(3,4-dimethoxyphenyl)-5-ethyl-2,3,4,5-tetrahydropyridazin-3-one, m.p. 81°;

[0182] 2-(4-tert-butylcarbonylaminobenzyl)-6-(3,4-dimethoxyphenyl)-5-ethyl-2,3,4,5-tetrahydropyridazin-3-one;

[0183] 2-(4-butyrylaminobenzyl)-6-(3,4-dimethoxyphenyl)-5-ethyl-2,3,4,5-tetrahydropyridazin-3-one, m.p. 117°;

[0184] 2-(4-isobutyrylaminobenzyl)-6-(3,4-dimethoxyphenyl)-5-ethyl-2,3,4,5-tetrahydropyridazin-3-one;

[0185] 2-(4-methoxycarbonylaminobenzyl)-6-(3,4-dimethoxyphenyl)-5-ethyl-2,3,4,5-tetrahydropyridazin-3-one, m.p. 144°;

[0186] 2-(4-pivalylaminobenzyl)-6-(3,4-dimethoxyphenyl)-5-ethyl-2,3,4,5-tetrahydropyridazin-3-one;

[0187] 2-(4-cyclopentylcarbamoylbenzyl)-6-(3,4-dimethoxyphenyl)-5-ethyl-2,3,4,5-tetrahydropyridazin-3-one;

[0188] 2-(4-ethoxycarbonylaminobenzyl)-6-(3,4-dimethoxyphenyl)-5-ethyl-2,3,4,5-tetrahydropyridazin-3-one, m.p. 154°;

[0189] 2-(4-methoxalylaminobenzyl)-6-(3,4-dimethoxyphenyl)-5-ethyl-2,3,4,5-tetrahydropyridazin-3-one;

[0190] b 2-(4-ureidobenzyl)-6-(3,4-dimethoxyphenyl)-5-ethyl-2,3,4,5-tetrahydropyridazin-3-one;

[0191] 2-(4-pentanoylaminobenzyl)-6-(3,4-dimethoxyphenyl)-5-ethyl-2,3,4,5-tetrahydropyridazin-3-one;

[0192] 2-(4-hexanoylaminobenzyl)-6-(3,4-dimethoxyphenyl)-5-ethyl-2,3,4,5-tetrahydropyridazin-3-one;

[0193] 2-(4-pentafluoropropionylaminobenzyl)-6-(3,4-dimethoxyphenyl)-5-ethyl-2,3,4,5-tetrahydropyridazin-3-one;

[0194] 2-(4-acetamidobenzyl)-6-(3-ethoxy-4-methoxyphenyl)-5-ethyl-2,3,4,5-tetrahydropyridazin-3-one;

[0195] 2-(4-trifluoroacetamidobenzyl)-6-(3-ethoxy-4-methoxyphenyl)-5-ethyl-2,3,4,5-tetrahydropyridazin-3-one;

[0196] 2-(4-methylsulfonamidobenzyl)-6-(3-ethoxy-4-methoxyphenyl)-5-ethyl-2,3,4,5-tetrahydropyridazin-3-one;

[0197] 2-(4-propionylaminobenzyl)-6-(3-ethoxy-4-methoxyphenyl)-5-ethyl-2,3,4,5-tetrahydropyridazin-3-one;

[0198] 2-(4-butyrylaminobenzyl)-6-(3-ethoxy-4-methoxyphenyl)-5-ethyl-2,3,4,5-tetrahydropyridazin-3-one;

[0199] 2-(4-isobutyrylaminobenzyl)-6-(3-ethoxy-4-methoxyphenyl)-5-ethyl-2,3,4,5-tetrahydropyridazin-3-one;

[0200] 2-(4-methoxycarbonylaminobenzyl)-6-(3-ethoxy-4-methoxyphenyl)-5-ethyl-2,3,4,5-tetrahydropyridazin-3-one;

[0201] 2-(4-pivalylaminobenzyl)-6-(3-ethoxy-4-methoxyphenyl)-5-ethyl-2,3,4,5-tetrahydropyridazin-3-one;

[0202] 2-(4-cyclopentylcarbamoylbenzyl)-6-(3-ethoxy-4-methoxyphenyl)-5-ethyl-2,3,4,5-tetrahydropyridazin-3-one;

[0203] 2-(4-ethoxycarbonylaminobenzyl)-6-(3-ethoxy-4-methoxyphenyl)-5-ethyl-2,3,4,5-tetrahydropyridazin-3-one;

[0204] 2-(4-methoxalylaminobenzyl)-6-(3-ethoxy-4-methoxyphenyl)-5-ethyl-2,3,4,5-tetrahydropyridazin-3-one;

[0205] 2-(4-ureidobenzyl)-6-(3-ethoxy-4-methoxyphenyl)-5-ethyl-2,3,4,5-tetrahydropyridazin-3-one;

[0206] 2-(4-pentanoylaminobenzyl)-6-(3-ethoxy-4-methoxyphenyl)-5-ethyl-2,3,4,5-tetrahydropyridazin-3-one;

[0207] 2-(4-hexanoylaminobenzyl)-6-(3-ethoxy-4-methoxyphenyl)-5-ethyl-2,3,4,5-tetrahydropyridazin-3-one;

[0208] 2-(4-pentafluoropropionylaminobenzyl)-6-(3-ethoxy-4-methoxyphenyl)-5-ethyl-2,3,4,5-tetrahydropyridazin-3-one;

[0209] 2-(4-acetamidobenzyl)-6-(3-cyclopentyloxy-4-methoxyphenyl)-5-ethyl-2,3,4,5-tetrahydropyridazin-3-one;

[0210] 2-(4-trifluoroacetamidobenzyl)-6-(3-cyclopentyloxy-4-methoxyphenyl )-5-ethyl-2,3,4,5-tetrahydropyridazin-3-one, m.p. 162°;

[0211] 2-(4-methylsulfonamidobenzyl)-6-(3-cyclopentyloxy-4-methoxyphenyl)-5-ethyl-2,3,4,5-tetrahydropyridazin-3-one;

[0212] 2-(4-propionylaminobenzyl)-6-(3-cyclopentyloxy-4-methoxyphenyl)-5-ethyl-2,3,4,5-tetrahydropyridazin-3-one, m.p. 69°;

[0213] 2-(4-tert-butylcarbonylaminobenzyl)-6-(3-cyclopentyloxy-4-methoxyphenyl)-5-ethyl-2,3,4,5-tetrahydropyridazin-3-one;

[0214] 2-(4-butyrylaminobenzyl)-6-(3-cyclopentyloxy-4-methoxyphenyl)-5-ethyl-2,3,4,5-tetrahydropyridazin-3-one;

[0215] 2-(4-isobutyrylaminobenzyl)-6-(3-cyclopentyloxy-4-methoxyphenyl)-5-ethyl-2,3,4,5-tetrahydropyridazin-3-one;

[0216] 2-(4-methoxycarbonylaminobenzyl)-6-(3-cyclopentyloxy-4-methoxyphenyl)-5-ethyl-2,3,4,5-tetrahydropyridazin-3-one;

[0217] 2-(4-pivalylaminobenzyl)-6-(3-cyclopentyloxy-4-methoxyphenyl)-5-ethyl-2,3,4,5-tetrahydropyridazin-3-one;

[0218] 2-(4-cyclopentylcarbamoylbenzyl)-6-(3-cyclopentyloxy-4-methoxyphenyl)-5-ethyl-2,3,4,5-tetrahydropyridazin-3-one;

[0219] 2-(4-ethoxycarbonylaminobenzyl)-6-(3-cyclopentyloxy-4-methoxyphenyl)-5-ethyl-2,3,4,5-tetrahydropyridazin-3-one, m.p. 73°;

[0220] 2-(4-methoxalylaminobenzyl)-6-(3-cyclopentyloxy-4-methoxyphenyl )-5-ethyl-2,3,4,5-tetrahydropyridazin-3-one;

[0221] 2-(4-ureidobenzyl)-6-(3-cyclopentyloxy-4-methoxyphenyl)-5-ethyl-2,3,4,5-tetrahydropyridazin-3-one;

[0222] 2-(4-pentanoylaminobenzyl)-6-(3-cyclopentyloxy-4-methoxyphenyl)-5-ethyl-2,3,4,5-tetrahydropyridazin-3-one;

[0223] 2-(4-hexanoylaminobenzyl)-6-(3-cyclopentyloxy-4-methoxyphenyl)-5-ethyl-2,3,4,5-tetrahydropyridazin-3-one;

[0224] 2-(4-pentafluoropropionylaminobenzyl)-6-(3-cyclopentyloxy-4-methoxyphenyl)-5-ethyl-2,3,4,5-tetrahydropyridazin-3-one;

[0225] 2-(4-acetamidophenethyl)-6-(3,4-dimethoxyphenyl)-5-ethyl-2,3,4,5-tetrahydropyridazin-3-one;

[0226] 2-(4-trifluoroacetamidophenethyl)-6-(3,4-dimethoxyphenyl)-5-ethyl-2,3,4,5-tetrahydropyridazin-3-one;

[0227] 2-(4-methylsulfonamidophenethyl)-6-(3,4-dimethoxyphenyl)-5-ethyl-2,3,4,5-tetrahydropyridazin-3-one;

[0228] 2-(4-propionylaminophenethyl)-6-(3,4-dimethoxyphenyl)-5-ethyl-2,3,4,5-tetrahydropyridazin-3-one;

[0229] 2-(4-butyrylaminophenethyl)-6-(3,4-dimethoxyphenyl)-5-ethyl-2,3,4,5-tetrahydropyridazin-3-one;

[0230] 2-(4-isobutyrylaminophenethyl)-6-(3,4-dimethoxyphenyl)-5-ethyl-2,3,4,5-tetrahydropyridazin-3-one;

[0231] 2-(4-methoxycarbonylaminophenethyl)-6-(3,4-dimethoxyphenyl)-5-ethyl-2,3,4,5-tetrahydropyridazin-3-one;

[0232] 2-(4-pivalylaminophenethyl)-6-(3,4-dimethoxyphenyl)-5-ethyl-2,3,4,5-tetrahydropyridazin-3-one;

[0233] 2-(4-cyclopentylcarbamoylphenethyl)-6-(3,4-dimethoxyphenyl)-5-ethyl-2,3,4,5-tetrahydropyridazin-3-one;

[0234] 2-(4-ethoxycarbonylaminophenethyl)-6-(3,4-dimethoxyphenyl)-5-ethyl-2,3,4,5-tetrahydropyridazin-3-one;

[0235] 2-(4-methoxalylaminophenethyl)-6-(3,4-dimethoxyphenyl)-5-ethyl-2,3,4,5-tetrahydropyridazin-3-one;

[0236] 2-(4-ureidophenethyl)-6-(3,4-dimethoxyphenyl)-5-ethyl-2,3,4,5-tetrahydropyridazin-3-one;

[0237] 2-(4-pentanoylaminophenethyl)-6-(3,4-dimethoxyphenyl)-5-ethyl-2,3,4,5-tetrahydropyridazin-3-one;

[0238] 2-(4-hexanoylaminophenethyl)-6-(3,4-dimethoxyphenyl)-5-ethyl-2,3,4,5-tetrahydropyridazin-3-one;

[0239] 2-(4-pentafluoropropionylaminophenethyl)-6-(3,4-dimethoxyphenyl)-5-ethyl-2,3,4,5-tetrahydropyridazin-3-one;

[0240] 2-(3-acetamidobenzyl)-6-(3,4-dimethoxyphenyl)-5-ethyl-2,3,4,5-tetrahydropyridazin-3-one;

[0241] 2-(3-trifluoroacetamidobenzyl)-6-(3,4-dimethoxyphenyl )-5-ethyl-2,3,4,5-tetrahydropyridazin-3-one, m.p. 142°;

[0242] 2-(3-methylsulfonamidobenzyl)-6-(3,4-dimethoxyphenyl)-5-ethyl-2,3,4,5-tetrahydropyridazin-3-one;

[0243] 2-(3-propionylaminobenzyl)-6-(3,4-dimethoxyphenyl)-5-ethyl-2,3,4,5-tetrahydropyridazin-3-one, m.p. 126°;

[0244] 2-(3-butyrylaminobenzyl)-6-(3,4-dimethoxyphenyl)-5-ethyl-2,3,4,5-tetrahydropyridazin-3-one;

[0245] 2-(3-isobutyrylaminobenzyl)-6-(3,4-dimethoxyphenyl)-5-ethyl-2,3,4,5-tetrahydropyridazin-3-one;

[0246] 2-(3-methoxycarbonylaminobenzyl)-6-(3,4-dimethoxyphenyl)-5-ethyl-2,3,4,5-tetrahydropyridazin-3-one;

[0247] 2-(3-pivalylaminobenzyl)-6-(3,4-dimethoxyphenyl)-5-ethyl-2,3,4,5-tetrahydropyridazin-3-one;

[0248] 2-(3-cyclopentylcarbamoylbenzyl)-6-(3,4-dimethoxyphenyl)-5-ethyl-2,3,4,5-tetrahydropyridazin-3-one;

[0249] 2-(3-ethoxycarbonylaminobenzyl)-6-(3,4-dimethoxyphenyl)-5-ethyl-2,3,4,5-tetrahydropyridazin-3-one, m.p. 54°;

[0250] 2-(3-methoxalylaminobenzyl)-6-(3,4-dimethoxyphenyl)-5-ethyl-2,3,4,5-tetrahydropyridazin-3-one;

[0251] 2-(3-ureidobenzyl)-6-(3,4-dimethoxyphenyl)-5-ethyl-2,3,4,5-tetrahydropyridazin-3-one;

[0252] 2-(3-pentanoylaminobenzyl)-6-(3,4-dimethoxyphenyl)-5-ethyl-2,3,4,5-tetrahydropyridazin-3-one;

[0253] 2-(3-hexanoylaminobenzyl)-6-(3,4-dimethoxyphenyl)-5-ethyl-2,3,4,5-tetrahydropyridazin-3-one;

[0254] 2-(3-pentafluoropropionylaminobenzyl)-6-(3,4-dimethoxyphenyl)-5-ethyl-2,3,4,5-tetrahydropyridazin-3-one;

[0255] 2-(4-acetamidobenzyl)-6-(3-fluoromethoxy-4-methoxyphenyl)-5-ethyl-2,3,4,5-tetrahydropyridazin-3-one;

[0256] 2-(4-trifluoroacetamidobenzyl)-6-(3-fluoromethoxy-4-methoxyphenyl)-5-ethyl-2,3,4,5-tetrahydropyridazin-3-one;

[0257] 2-(4-methylsulfonamidobenzyl)-6-(3-fluoromethoxy-4-methoxyphenyl)-5-ethyl-2,3,4,5-tetrahydropyridazin-3-one;

[0258] 2-(4-propionylaminobenzyl)-6-(3-fluoromethoxy-4-methoxyphenyl)-5-ethyl-2,3,4,5-tetrahydropyridazin-3-one;

[0259] 2-(4-butyrylaminobenzyl)-6-(3-fluoromethoxy-4-methoxyphenyl)-5-ethyl-2,3,4,5-tetrahydropyridazin-3-one;

[0260] 2-(4-isobutyrylaminobenzyl)-6-(3-fluoromethoxy-4-methoxyphenyl)-5-ethyl-2,3,4,5-tetrahydropyridazin-3-one;

[0261] 2-(4-methoxycarbonylaminobenzyl)-6-(3-fluoromethoxy-4-methoxyphenyl)-5-ethyl-2,3,4,5-tetrahydropyridazin-3-one;

[0262] 2-(4-pivalylaminobenzyl)-6-(3-fluoromethoxy-4-methoxyphenyl)-5-ethyl-2,3,4,5-tetrahydropyridazin-3-one;

[0263] 2-(4-cyclopentylcarbamoylbenzyl)-6-(3-fluoromethoxy-4-methoxyphenyl)-5-ethyl-2,3,4,5-tetrahydropyridazin-3-one;

[0264] 2-(4-ethoxycarbonylaminobenzyl)-6-(3-fluoromethoxy-4-methoxyphenyl)-5-ethyl-2,3,4,5-tetrahydropyridazin-3-one;

[0265] 2-(4-methoxalylaminobenzyl)-6-(3-fluoromethoxy-4-methoxyphenyl)-5-ethyl-2,3,4,5-tetrahydropyridazin-3-one;

[0266] 2-(4-ureidobenzyl)-6-(3-fluoromethoxy-4-methoxyphenyl)-5-ethyl-2,3,4,5-tetrahydropyridazin-3-one;

[0267] 2-(4-pentanoylaminobenzyl)-6-(3-fluoromethoxy-4-methoxyphenyl)-5-ethyl-2,3,4,5-tetrahydropyridazin-3-one;

[0268] 2-(4-hexanoylaminobenzyl)-6-(3-fluoromethoxy-4-methoxyphenyl)-5-ethyl-2,3,4,5-tetrahydropyridazin-3-one;

[0269] 2-(4-pentafluoropropionylaminobenzyl)-6-(3-fluoromethoxy-4-methoxyphenyl)-5-ethyl-2,3,4,5-tetrahydropyridazin-3-one;

[0270] 2-(4-acetamidobenzyl)-6-(3-difluoromethoxy-4-methoxyphenyl)-5-ethyl-2,3,4,5-tetrahydropyridazin-3-one;

[0271] 2-(4-trifluoroacetamidobenzyl)-6-(3-difluoromethoxy-4-methoxyphenyl)-5-ethyl-2,3,4,5-tetrahydropyridazin-3-one;

[0272] 2-(4-methylsulfonamidobenzyl)-6-(3-difluoromethoxy-4-methoxyphenyl)-5-ethyl-2,3,4,5-tetrahydropyridazin-3-one;

[0273] 2-(4-propionylaminobenzyl)-6-(3-difluoromethoxy-4-methoxyphenyl)-5-ethyl-2,3,4,5-tetrahydropyridazin-3-one;

[0274] 2-(4-butyrylaminobenzyl)-6-(3-difluoromethoxy-4-methoxyphenyl)-5-ethyl-2,3,4,5-tetrahydropyridazin-3-one;

[0275] 2-(4-isobutyrylaminobenzyl)-6-(3-difluoromethoxy-4-methoxyphenyl)-5-ethyl-2,3,4,5-tetrahydropyridazin-3-one;

[0276] 2-(4-methoxycarbonylaminobenzyl)-6-(3-difluoromethoxy-4-methoxyphenyl)-5-ethyl-2,3,4,5-tetrahydropyridazin-3-one;

[0277] 2-(4-pivalylaminobenzyl)-6-(3-difluoromethoxy-4-methoxyphenyl)-5-ethyl-2,3,4,5-tetrahydropyridazin-3-one;

[0278] 2-(4-cyclopentylcarbamoylbenzyl)-6-(3-difluoromethoxy-4-methoxyphenyl)-5-ethyl-2,3,4,5-tetrahydropyridazin-3-one;

[0279] 2-(4-ethoxycarbonylaminobenzyl)-6-(3-difluoromethoxy-4-methoxyphenyl)-5-ethyl-2,3,4,5-tetrahydropyridazin-3-one;

[0280] 2-(4-methoxalylaminobenzyl)-6-(3-difluoromethoxy-4-methoxyphenyl)-5-ethyl-2,3,4,5-tetrahydropyridazin-3-one;

[0281] 2-(4-ureidobenzyl)-6-(3-difluoromethoxy-4-methoxyphenyl)-5-ethyl-2,3,4,5-tetrahydropyridazin-3-one;

[0282] 2-(4-pentanoylaminobenzyl)-6-(3-difluoromethoxy-4-methoxyphenyl)-5-ethyl-2,3,4,5-tetrahydropyridazin-3-one;

[0283] 2-(4-hexanoylaminobenzyl)-6-(3-difluoromethoxy-4-methoxyphenyl)-5-ethyl-2,3,4,5-tetrahydropyridazin-3-one;

[0284] 2-(4-pentafluoropropionylaminobenzyl)-6-(3-difluoromethoxy-4-methoxyphenyl)-5-ethyl-2,3,4,5-tetrahydropyridazin-3-one;

[0285] 2-(4-acetamidobenzyl)-6-(3-trifluoromethoxy-4-methoxyphenyl)-5-ethyl-2,3,4,5-tetrahydropyridazin-3-one;

[0286] 2-(4-trifluoroacetamidobenzyl)-6-(3-trifluoromethoxy-4-methoxyphenyl)-5-ethyl-2,3,4,5-tetrahydropyridazin-3-one;

[0287] 2-(4-methylsulfonamidobenzyl)-6-(3-trifluoromethoxy-4-methoxyphenyl)-5-ethyl-2,3,4,5-tetrahydropyridazin-3-one;

[0288] 2-(4-propionylaminobenzyl)-6-(3-trifluoromethoxy-4-methoxyphenyl)-5-ethyl-2,3,4,5-tetrahydropyridazin-3-one;

[0289] 2-(4-butyrylaminobenzyl)-6-(3-trifluoromethoxy-4-methoxyphenyl)-5-ethyl-2,3,4,5-tetrahydropyridazin-3-one;

[0290] 2-(4-isobutyrylaminobenzyl)-6-(3-trifluoromethoxy-4-methoxyphenyl)-5-ethyl-2,3,4,5-tetrahydropyridazin-3-one;

[0291] 2-(4-methoxycarbonylaminobenzyl)-6-(3-trifluoromethoxy-4-methoxyphenyl)-5-ethyl-2,3,4,5-tetrahydropyridazin-3-one;

[0292] 2-(4-pivalylaminobenzyl)-6-(3-trifluoromethoxy-4-methoxyphenyl)-5-ethyl-2,3,4,5-tetrahydropyridazin-3-one;

[0293] 2-(4-cyclopentylcarbamoylbenzyl)-6-(3-trifluoromethoxy-4-methoxyphenyl)-5-ethyl-2,3,4,5-tetrahydropyridazin-3-one;

[0294] 2-(4-ethoxycarbonylaminobenzyl)-6-(3-trifluoromethoxy-4-methoxyphenyl)-5-ethyl-2,3,4,5-tetrahydropyridazin-3-one;

[0295] 2-(4-methoxalylaminobenzyl)-6-(3-trifluoromethoxy-4-methoxyphenyl)-5-ethyl-2,3,4,5-tetrahydropyridazin-3-one;

[0296] 2-(4-ureidobenzyl)-6-(3-trifluoromethoxy-4-methoxyphenyl)-5-ethyl-2,3,4,5-tetrahydropyridazin-3-one;

[0297] 2-(4-pentanoylaminobenzyl)-6-(3-trifluoromethoxy-4-methoxyphenyl)-5-ethyl-2,3,4,5-tetrahydropyridazin-3-one;

[0298] 2-(4-hexanoylaminobenzyl)-6-(3-trifluoromethoxy-4-methoxyphenyl)-5-ethyl-2,3,4,5-tetrahydropyridazin-3-one;

[0299] 2-(4-pentafluoropropionylaminobenzyl)-6-(3-trifluoromethoxy-4-methoxyphenyl)-5-ethyl-2,3,4,5-tetrahydropyridazin-3-one;

[0300] 2-(4-acetamidobenzyl)-6-(3-methoxy-4-fluoromethoxyphenyl)-5-ethyl-2,3,4,5-tetrahydropyridazin-3-one;

[0301] 2-(4-trifluoroacetamidobenzyl)-6-(3-methoxy-4-fluoromethoxyphenyl)-5-ethyl-2,3,4,5-tetrahydropyridazin-3-one;

[0302] 2-(4-methylsulfonamidobenzyl)-6-(3-methoxy-4-fluoromethoxyphenyl)-5-ethyl-2,3,4,5-tetrahydropyridazin-3-one;

[0303] 2-(4-propionylaminobenzyl)-6-(3-methoxy-4-fluoromethoxyphenyl)-5-ethyl-2,3,4,5-tetrahydropyridazin-3-one;

[0304] 2-(4-butyrylaminobenzyl)-6-(3-methoxy-4-fluoromethoxyphenyl)-5-ethyl-2,3,4,5-tetrahydropyridazin-3-one;

[0305] 2-(4-isobutyrylaminobenzyl)-6-(3-methoxy-4-fluoromethoxyphenyl)-5-ethyl-2,3,4,5-tetrahydropyridazin-3-one;

[0306] 2-(4-methoxycarbonylaminobenzyl)-6-(3-methoxy-4-fluoromethoxyphenyl)-5-ethyl-2,3,4,5-tetrahydropyridazin-3-one;

[0307] 2-(4-pivalylaminobenzyl)-6-(3-methoxy-4-fluoromethoxyphenyl)-5-ethyl-2,3,4,5-tetrahydropyridazin-3-one;

[0308] 2-(4-cyclopentylcarbamoylbenzyl)-6-(3-methoxy-4-fluoromethoxyphenyl)-5-ethyl-2,3,4,5-tetrahydropyridazin-3-one;

[0309] 2-(4-ethoxycarbonylaminobenzyl)-6-(3-methoxy-4-fluoromethoxyphenyl)-5-ethyl-2,3,4,5-tetrahydropyridazin-3-one;

[0310] 2-(4-methoxalylaminobenzyl)-6-(3-methoxy-4-fluoromethoxyphenyl)-5-ethyl-2,3,4,5-tetrahydropyridazin-3-one;

[0311] 2-(4-ureidobenzyl)-6-(3-methoxy-4-fluoromethoxyphenyl)-5-ethyl-2,3,4,5-tetrahydropyridazin-3-one;

[0312] 2-(4-pentanoylaminobenzyl)-6-(3-methoxy-4-fluoromethoxyphenyl)-5-ethyl-2,3,4,5-tetrahydropyridazin-3-one;

[0313] 2-(4-hexanoylaminobenzyl)-6-(3-methoxy-4-fluoromethoxyphenyl)-5-ethyl-2,3,4,5-tetrahydropyridazin-3-one;

[0314] 2-(4-pentafluoropropionylaminobenzyl)-6-(3-methoxy-4-fluoromethoxyphenyl)-5-ethyl-2,3,4,5-tetrahydropyridazin-3-one;

[0315] 2-(4-acetamidobenzyl)-6-(3-methoxy-4-difluoromethoxyphenyl)-5-ethyl-2,3,4,5-tetrahydropyridazin-3-one;

[0316] 2-(4-trifluoroacetamidobenzyl)-6-(3-methoxy-4-difluoromethoxyphenyl)-5-ethyl-2,3,4,5-tetrahydropyridazin-3-one;

[0317] 2-(4-methylsulfonamidobenzyl)-6-(3-methoxy-4-difluoromethoxyphenyl)-5-ethyl-2,3,4,5-tetrahydropyridazin-3-one;

[0318] 2-(4-propionylaminobenzyl)-6-(3-methoxy-4-difluoromethoxyphenyl)-5-ethyl-2,3,4,5-tetrahydropyridazin-3-one;

[0319] 2-(4-butyrylaminobenzyl)-6-(3-methoxy-4-difluoromethoxyphenyl)-5-ethyl-2,3,4,5-tetrahydropyridazin-3-one;

[0320] 2-(4-isobutyrylaminobenzyl)-6-(3-methoxy-4-difluoromethoxyphenyl)-5-ethyl-2,3,4,5-tetrahydropyridazin-3-one;

[0321] 2-(4-methoxycarbonylaminobenzyl)-6-(3-methoxy-4-difluoromethoxyphenyl)-5-ethyl-2,3,4,5-tetrahydropyridazin-3-one;

[0322] 2-(4-pivalylaminobenzyl)-6-(3-methoxy-4-difluoromethoxyphenyl)-5-ethyl-2,3,4,5-tetrahydropyridazin-3-one;

[0323] 2-(4-cyclopentylcarbamoylbenzyl)-6-(3-methoxy-4-difluoromethoxyphenyl)-5-ethyl-2,3,4,5-tetrahydropyridazin-3-one;

[0324] 2-(4-ethoxycarbonylaminobenzyl)-6-(3-methoxy-4-difluoromethoxyphenyl)-5-ethyl-2,3,4,5-tetrahydropyridazin-3-one;

[0325] 2-(4-methoxalylaminobenzyl)-6-(3-methoxy-4-difluoromethoxyphenyl)-5-ethyl-2,3,4,5-tetrahydropyridazin-3-one;

[0326] 2-(4-ureidobenzyl)-6-(3-methoxy-4-difluoromethoxyphenyl)-5-ethyl-2,3,4,5-tetrahydropyridazin-3-one;

[0327] 2-(4-pentanoylaminobenzyl)-6-(3-methoxy-4-difluoromethoxyphenyl)-5-ethyl-2,3,4,5-tetrahydropyridazin-3-one;

[0328] 2-(4-hexanoylaminobenzyl)-6-(3-methoxy-4-difluoromethoxyphenyl)-5-ethyl-2,3,4,5-tetrahydropyridazin-3-one;

[0329] 2-(4-pentafluoropropionylaminobenzyl)-6-(3-methoxy-4-difluoromethoxyphenyl)-5-ethyl-2,3,4,5-tetrahydropyridazin-3-one;

[0330] 2-(4-acetamidobenzyl)-6-(3-methoxy-4-trifluoromethoxyphenyl)-5-ethyl-2,3,4,5-tetrahydropyridazin-3-one;

[0331] 2-(4-trifluoroacetamidobenzyl)-6-(3-methoxy-4-trifluoromethoxyphenyl)-5-ethyl-2,3,4,5-tetrahydropyridazin-3-one;

[0332] 2-(4-methylsulfonamidobenzyl)-6-(3-methoxy-4-trifluoromethoxyphenyl)-5-ethyl-2,3,4,5-tetrahydropyridazin-3-one;

[0333] 2-(4-propionylaminobenzyl)-6-(3-methoxy-4-trifluoromethoxyphenyl)-5-ethyl-2,3,4,5-tetrahydropyridazin-3-one;

[0334] 2-(4-butyrylaminobenzyl)-6-(3-methoxy-4-trifluoromethoxyphenyl)-5-ethyl-2,3,4,5-tetrahydropyridazin-3-one;

[0335] 2-(4-isobutyrylaminobenzyl)-6-(3-methoxy-4-trifluoromethoxyphenyl)-5-ethyl-2,3,4,5-tetrahydropyridazin-3-one;

[0336] 2-(4-methoxycarbonylaminobenzyl)-6-(3-methoxy-4-trifluoromethoxyphenyl)-5-ethyl-2,3,4,5-tetrahydropyridazin-3-one;

[0337] 2-(4-pivalylaminobenzyl)-6-(3-methoxy-4-trifluoromethoxyphenyl)-5-ethyl-2,3,4,5-tetrahydropyridazin-3-one;

[0338] 2-(4-cyclopentylcarbamoylbenzyl)-6-(3-methoxy-4-trifluoromethoxyphenyl)-5-ethyl-2,3,4,5-tetrahydropyridazin-3-one;

[0339] 2-(4-ethoxycarbonylaminobenzyl)-6-(3-methoxy-4-trifluoromethoxyphenyl)-5-ethyl-2,3,4,5-tetrahydropyridazin-3-one;

[0340] 2-(4-methoxalylaminobenzyl)-6-(3-methoxy-4-trifluoromethoxyphenyl)-5-ethyl-2,3,4,5-tetrahydropyridazin-3-one;

[0341] 2-(4-ureidobenzyl)-6-(3-methoxy-4-trifluoromethoxyphenyl)-5-ethyl-2,3,4,5-tetrahydropyridazin-3-one;

[0342] 2-(4-pentanoylaminobenzyl)-6-(3-methoxy-4-trifluoromethoxyphenyl)-5-ethyl-2,3,4,5-tetrahydropyridazin-3-one;

[0343] 2-(4-hexanoylaminobenzyl)-6-(3-methoxy-4-trifluoromethoxyphenyl)-5-ethyl-2,3,4,5-tetrahydropyridazin-3-one;

[0344] 2-(4-pentafluoropropionylaminobenzyl)-6-(3-methoxy-4-trifluoromethoxyphenyl)-5-ethyl-2,3,4,5-tetrahydropyridazin-3-one;

[0345] 2-(4-acetamidobenzyl)-6-(3-ethoxy-4-methoxyphenyl)-2,3,4,5-tetrahydropyridazin-3-one, m.p. 170°;

[0346] 2-(4-trifluoroacetamidobenzyl)-6-(3-ethoxy-4-methoxyphenyl)-2,3,4,5-tetrahydropyridazin-3-one;

[0347] 2-(4-methylsulfonamidobenzyl)-6-(3-ethoxy-4-methoxyphenyl)-2,3,4,5-tetrahydropyridazin-3-one;

[0348] 2-(4-propionylaminobenzyl)-6-(3-ethoxy-4-methoxyphenyl)-2,3,4,5-tetrahydropyridazin-3-one;

[0349] 2-(4-butyrylaminobenzyl)-6-(3-ethoxy-4-methoxyphenyl)-2,3,4,5-tetrahydropyridazin-3-one;

[0350] 2-(4-isobutyrylaminobenzyl)-6-(3-ethoxy-4-methoxyphenyl)-2,3,4,5-tetrahydropyridazin-3-one;

[0351] 2-(4-methoxycarbonylaminobenzyl)-6-(3-ethoxy-4-methoxyphenyl)-2,3,4,5-tetrahydropyridazin-3-one;

[0352] 2-(4-pivalylaminobenzyl)-6-(3-ethoxy-4-methoxyphenyl)-2,3,4,5-tetrahydropyridazin-3-one;

[0353] 2-(4-cyclopentylcarbamoylbenzyl)-6-(3-ethoxy-4-methoxyphenyl)-2,3,4,5-tetrahydropyridazin-3-one;

[0354] 2-(4-ethoxycarbonylaminobenzyl)-6-(3-ethoxy-4-methoxyphenyl)-2,3,4,5-tetrahydropyridazin-3-one, m.p. 128°;

[0355] 2-(4-methoxalylaminobenzyl)-6-(3-ethoxy-4-methoxyphenyl)-2,3,4,5-tetrahydropyridazin-3-one;

[0356] 2-(4-ureidobenzyl)-6-(3-ethoxy-4-methoxyphenyl)-2,3,4,5-tetrahydropyridazin-3-one;

[0357] 2-(4-pentanoylaminobenzyl)-6-(3-ethoxy-4-methoxyphenyl)-2,3,4,5-tetrahydropyridazin-3-one;

[0358] 2-(4-hexanoylaminobenzyl)-6-(3-ethoxy-4-methoxyphenyl)-2,3,4,5-tetrahydropyridazin-3-one;

[0359] 2-(4-pentafluoropropionylaminobenzyl)-6-(3-ethoxy-4-methoxyphenyl)-2,3,4,5-tetrahydropyridazin-3-one;

[0360] 2-(4-acetamidobenzyl)-6-(3-cyclopentyloxy-4-methoxyphenyl)-2,3,4,5-tetrahydropyridazin-3-one;

[0361] 2-(4-trifluoroacetamidobenzyl)-6-(3-cyclopentyloxy-4-methoxyphenyl)-2,3,4,5-tetrahydropyridazin-3-one;

[0362] 2-(4-methylsulfonamidobenzyl)-6-(3-cyclopentyloxy-4-methoxyphenyl)-2,3,4,5-tetrahydropyridazin-3-one;

[0363] 2-(4-propionylaminobenzyl)-6-(3-cyclopentyloxy-4-methoxyphenyl)-2,3,4,5-tetrahydropyridazin-3-one;

[0364] 2-(4-tert-butylcarbonylaminobenzyl)-6-(3-cyclopentyloxy-4-methoxyphenyl)-2,3,4,5-tetrahydropyridazin-3-one;

[0365] 2-(4-butyrylaminobenzyl)-6-(3-cyclopentyloxy-4-methoxyphenyl)-2,3,4,5-tetrahydropyridazin-3-one;

[0366] 2-(4-isobutyrylaminobenzyl)-6-(3-cyclopentyloxy-4-methoxyphenyl)-2,3,4,5-tetrahydropyridazin-3-one;

[0367] 2-(4-methoxycarbonylaminobenzyl)-6-(3-cyclopentyloxy-4-methoxyphenyl)-2,3,4,5-tetrahydropyridazin-3-one;

[0368] 2-(4-pivalylaminobenzyl)-6-(3-cyclopentyloxy-4-methoxyphenyl)-2,3,4,5-tetrahydropyridazin-3-one;

[0369] 2-(4-cyclopentylcarbamoylbenzyl)-6-(3-cyclopentyloxy-4-methoxyphenyl)-2,3,4,5-tetrahydropyridazin-3-one;

[0370] 2-(4-ethoxycarbonylaminobenzyl)-6-(3-cyclopentyloxy-4-methoxyphenyl)-2,3,4,5-tetrahydropyridazin-3-one;

[0371] 2-(4-methoxalylaminobenzyl)-6-(3-cyclopentyloxy-4-methoxyphenyl)-2,3,4,5-tetrahydropyridazin-3-one;

[0372] 2-(4-ureidobenzyl)-6-(3-cyclopentyloxy-4-methoxyphenyl)-2,3,4,5-tetrahydropyridazin-3-one;

[0373] 2-(4-pentanoylaminobenzyl)-6-(3-cyclopentyloxy-4-methoxyphenyl)-2,3,4,5-tetrahydropyridazin-3-one;

[0374] 2-(4-hexanoylaminobenzyl)-6-(3-cyclopentyloxy-4-methoxyphenyl)-2,3,4,5-tetrahydropyridazin-3-one;

[0375] 2-(4-pentafluoropropionylaminobenzyl)-6-(3-cyclopentyloxy-4-methoxyphenyl)-2,3,4,5-tetrahydropyridazin-3-one;

[0376] 2-(4-acetamidophenethyl)-6-(3,4-dimethoxyphenyl)-2,3,4,5-tetrahydropyridazin-3-one;

[0377] 2-(4-trifluoroacetamidophenethyl)-6-(3,4-dimethoxyphenyl)-2,3,4,5-tetrahydropyridazin-3-one;

[0378] 2-(4-methylsulfonamidophenethyl)-6-(3,4-dimethoxyphenyl)-2,3,4,5-tetrahydropyridazin-3-one;

[0379] 2-(4-propionylaminophenethyl)-6-(3,4-dimethoxyphenyl)-2,3,4,5-tetrahydropyridazin-3-one;

[0380] 2-(4-butyrylaminophenethyl)-6-(3,4-dimethoxyphenyl)-2,3,4,5-tetrahydropyridazin-3-one;

[0381] 2-(4-isobutyrylaminophenethyl)-6-(3,4-dimethoxyphenyl)-2,3,4,5-tetrahydropyridazin-3-one;

[0382] 2-(4-methoxycarbonylaminophenethyl)-6-(3,4-dimethoxyphenyl)-2,3,4,5-tetrahydropyridazin-3-one;

[0383] 2-(4-pivalylaminophenethyl)-6-(3,4-dimethoxyphenyl)-2,3,4,5-tetrahydropyridazin-3-one;

[0384] 2-(4-cyclopentylcarbamoylphenethyl)-6-(3,4-dimethoxyphenyl)-2,3,4,5-tetrahydropyridazin-3-one;

[0385] 2-(4-ethoxycarbonylaminophenethyl)-6-(3,4-dimethoxyphenyl)-2,3,4,5-tetrahydropyridazin-3-one;

[0386] 2-(4-methoxalylaminophenethyl)-6-(3,4-dimethoxyphenyl)-2,3,4,5-tetrahydropyridazin-3-one;

[0387] 2-(4-ureidophenethyl)-6-(3,4-dimethoxyphenyl)-2,3,4,5-tetrahydropyridazin-3-one;

[0388] 2-(4-pentanoylaminophenethyl)-6-(3,4-dimethoxyphenyl)-2,3,4,5-tetrahydropyridazin-3-one;

[0389] 2-(4-hexanoylaminophenethyl)-6-(3,4-dimethoxyphenyl)-2,3,4,5-tetrahydropyridazin-3-one;

[0390] 2-(4-pentafluoropropionylaminophenethyl)-6-(3,4-dimethoxyphenyl)-2,3,4,5-tetrahydropyridazin-3-one;

[0391] 2-(3-acetamidobenzyl)-6-(3,4-dimethoxyphenyl)-2,3,4,5-tetrahydropyridazin-3-one, m.p. 105°;

[0392] 2-(3-trifluoroacetamidobenzyl)-6-(3,4-dimethoxyphenyl)-2,3,4,5-tetrahydropyridazin-3-one, m.p. 136°;

[0393] 2-(3-methylsulfonamidobenzyl)-6-(3,4-dimethoxyphenyl)-2,3,4,5-tetrahydropyridazin-3-one, m.p. 177°;

[0394] 2-(3-propionylaminobenzyl)-6-(3,4-dimethoxyphenyl)-2,3,4,5-tetrahydropyridazin-3-one, m.p. 152°;

[0395] 2-(3-tert-butylcarbonylaminobenzyl)-6-(3,4-dimethoxyphenyl)-2,3,4,5-tetrahydropyridazin-3-one;

[0396] 2-(3-butyrylaminobenzyl)-6-(3,4-dimethoxyphenyl)-2,3,4,5-tetrahydropyridazin-3-one;

[0397] 2-(3-isobutyrylaminobenzyl)-6-(3,4-dimethoxyphenyl)-2,3,4,5-tetrahydropyridazin-3-one;

[0398] 2-(3-methoxycarbonylaminobenzyl)-6-(3,4-dimethoxyphenyl)-2,3,4,5-tetrahydropyridazin-3-one;

[0399] 2-(3-pivalylaminobenzyl)-6-(3,4-dimethoxyphenyl)-2,3,4,5-tetrahydropyridazin-3-one;

[0400] 2-(3-cyclopentylcarbamoylbenzyl)-6-(3,4-dimethoxyphenyl)-2,3,4,5-tetrahydropyridazin-3-one;

[0401] 2-(3-ethoxycarbonylaminobenzyl)-6-(3,4-dimethoxyphenyl)-2,3,4,5-tetrahydropyridazin-3-one, m.p. 179°;

[0402] 2-(3-methoxalylaminobenzyl)-6-(3,4-dimethoxyphenyl)-2,3,4,5-tetrahydropyridazin-3-one;

[0403] 2-(3-ureidobenzyl)-6-(3,4-dimethoxyphenyl)-2,3,4,5-tetrahydropyridazin-3-one;

[0404] 2-(3-pentanoylaminobenzyl)-6-(3,4-dimethoxyphenyl)-2,3,4,5-tetrahydropyridazin-3-one;

[0405] 2-(3-hexanoylaminobenzyl)-6-(3,4-dimethoxyphenyl)-2,3,4,5-tetrahydropyridazin-3-one;

[0406] 2-(3-pentafluoropropionylaminobenzyl)-6-(3,4-dimethoxyphenyl)-2,3,4,5-tetrahydropyridazin-3-one;

[0407] 2-(3-acetamidobenzyl)-6-(3-cyclopentyloxy-4-methoxyphenyl)-5-ethyl-2,3,4,5-tetrahydropyridazin-3-one;

[0408] 2-(3-trifluoroacetamidobenzyl)-6-(3-cyclopentyloxy-4-methoxyphenyl)-5-ethyl-2,3,4,5-tetrahydropyridazin-3-one, m.p. 70°;

[0409] 2-(3-methylsulfonamidobenzyl)-6-(3-cyclopentyloxy-4-methoxyphenyl)-5-ethyl-2,3,4,5-tetrahydropyridazin-3-one;

[0410] 2-(3-propionylaminobenzyl)-6 (3-cyclopentyloxy-4-methoxyphenyl)-5-ethyl-2,3,4,5-tetrahydropyridazin-3-one, m.p. 113°;

[0411] 2-(3-tert-butylcarbonylaminobenzyl)-6-(3-cyclopentyloxy-4-methoxyphenyl)-5-ethyl-2,3,4,5-tetrahydropyridazin-3-one;

[0412] 2-(3-butyrylaminobenzyl)-6-(3-cyclopentyloxy-4-methoxyphenyl)-5-ethyl-2,3,4,5-tetrahydropyridazin-3-one;

[0413] 2-(3-isobutyrylaminobenzyl)-6-(3-cyclopentyloxy-4-methoxyphenyl)-5-ethyl-2,3,4,5-tetrahydropyridazin-3-one;

[0414] 2-(3-methoxycarbonylaminobenzyl)-6-(3-cyclopentyloxy-4-methoxyphenyl)-5-ethyl-2,3,4,5-tetrahydropyridazin-3-one;

[0415] 2-(3-pivalylaminobenzyl)-6-(3-cyclopentyloxy-4-methoxyphenyl)-5-ethyl-2,3,4,5-tetrahydropyridazin-3-one;

[0416] 2-(3-cyclopentylcarbamoylbenzyl)-6-(3-cyclopentyloxy-4-methoxyphenyl)-5-ethyl-2,3,4,5-tetrahydropyridazin-3-one;

[0417] 2-(3-ethoxycarbonylaminobenzyl)-6-(3-cyclopentyloxy-4-methoxyphenyl)-5-ethyl-2,3,4,5-tetrahydropyridazin-3-one, m.p. 153°;

[0418] 2-(3-methoxalylaminobenzyl)-6-(3-cyclopentyloxy-4-methoxyphenyl)-5-ethyl-2,3,4,5-tetrahydropyridazin-3-one;

[0419] 2-(3-ureidobenzyl)-6-(3-cyclopentyloxy-4-methoxyphenyl)-5-ethyl-2,3,4,5-tetrahydropyridazin-3-one;

[0420] 2-(3-pentanoylaminobenzyl)-6-(3-cyclopentyloxy-4-methoxyphenyl)-5-ethyl-2,3,4,5-tetrahydropyridazin-3-one;

[0421] 2-(3-hexanoylaminobenzyl)-6-(3-cyclopentyloxy-4-methoxyphenyl)-5-ethyl-2,3,4,5-tetrahydropyridazin-3-one;

[0422] 2-(3-pentafluoropropionylaminobenzyl)-6-(3-cyclopentyloxy-4-methoxyphenyl)-5-ethyl-2,3,4,5-tetrahydropyridazin-3-one;

[0423] 2-(4-nitrobenzyl)-6-(3,4-dimethoxyphenyl)-2,3,4,5-tetrahydropyridazin-3-one, m.p. 126°;

[0424] 2-(4-nitrophenyl)-6-(3,4-dimethoxyphenyl)-2,3,4,5-tetrahydropyridazin-3-one;

[0425] b) compounds, disclosed in EP 0 763 534,selected from the group consisting of

[0426] 2-(4-nicotinoylaminobenzyl)-6-(3,4-dimethoxyphenyl)-2,3,4,5-tetrahydropyridazin-3-one;

[0427] 2-(3-nicotinoylaminobenzyl)-6-(3,4-dimethoxyphenyl)-2,3,4,5-tetrahydropyridazin-3-one;

[0428] 2-(2-nicotinoylaminobenzyl)-6-(3,4-dimethoxyphenyl)-2,3,4,5-tetrahydropyridazin-3-one;

[0429] 2-(4-nicotinoylaminobenzyl)-6-(3,4-dimethoxyphenyl)-5-ethyl-2,3,4,5-tetrahydropyridazin-3-one;

[0430] 2-(3-nicotinoylaminobenzyl)-6-(3,4-dimethoxyphenyl)-5-ethyl-2,3,4,5-tetrahydropyridazin-3-one;

[0431] 2-(2-nicotinoylaminobenzyl)-6-(3,4-dimethoxyphenyl)-5-ethyl-2,3,4,5-tetrahydropyridazin-3-one;

[0432] 2-(4-nicotinoylaminobenzyl)-6-(3-methoxy-4-trifluoromethoxyphenyl)-5-ethyl-2,3,4,5-tetrahydropyridazin-3-one;

[0433] 2-(4-nicotinoylaminobenzyl)-6-(3-methoxy-4-difluoromethoxyphenyl)-5-ethyl-2,3,4,5-tetrahydropyridazin-3-one;

[0434] 2-(4-nicotinoylaino-benzyl)-6-(3-methoxy-4-fluoromethoxyphenyl)-5-ethyl-2,3,4,5-tetrahydropyridazin-3-one;

[0435] 2-(4-nicotinoylaminobenzyl)-6-(3-difluoromethoxy-4-methoxyphenyl)-5-ethyl-2,3,4,5-tetrahydropyridazin-3-one;

[0436] 2-(4-nicotinoylaminobenzyl)-6-(3-trifluoromethoxy-4-methoxyphenyl)-5-ethyl-2,3,4,5-tetrahydropyridazin-3-one;

[0437] 2-(4-nicotinoylaminobenzyl)-6-(3-fluoromethoxy-4-methoxyphenyl)-5-ethyl-2,3,4,5-tetrahydropyridazin-3-one;

[0438] 2-(4-nicotinoylaminobenzyl)-6-(3-methoxy-4-ethoxyphenyl)-5-ethyl-2,3,4,5-tetrahydropyridazin-3-one;

[0439] 2-(4-nicotinoylaminobenzyl)-6-(3-ethoxy-4-methoxyphenyl)-5-ethyl-2,3,4,5-tetrahydropyridazin-3-one;

[0440] 2-(4-nicotinoylaminobenzyl)-6-(3-hydroxy-4-methoxyphenyl)-5-ethyl-2,3,4,5-tetrahydropyridazin-3-one;

[0441] 2-(4-nicotinoylaminobenzyl)-6-(4-methylsulfonylphenyl)-5-ethyl-2,3,4,5-tetrahydropridazin-3-one;

[0442] 2-(4-nicotinoylaminobenzyl)-6-(4-methyleneoxyphenyl)-5-ethyl-2,3,4,5-tetrahydropyridazin-3-one;

[0443] 2-(4-nicotinoylaminobenzyl)-6-(3-cyclopentyloxy-4-methoxyphenyl)-5-ethyl-2,3,4,5-tetrahydropyridazin-3-one;

[0444] 2-(3-nicotinoylaminobenzyl)-6-(3-cyclopentyloxy-4-methoxyphenyl)-5-ethyl-2,3,4,5-tetrahydropyridazin-3-one;

[0445] 2-(4-nicotinoylaminophenethyl)-6-(3,4-dimethoxyphenyl)-2,3,4,5-tetrahydropyridazin-3-one;

[0446] 2-(4-nicotinoylaminophenethyl)-6-(3,4-dimethoxyphenyl)-5-ethyl-2,3,4,5-tetrahydropyridazin-3-one;

[0447] 3-(4-nicotinoylaminobenzyl)-5-(3,4-dimethoxyphenyl)-3,6-dihydro-1,3,4-thiadiazin-2-one;

[0448] 3-(3-nicotinoylaminobenzyl)-5-(3,4-dimethoxyphenyl)-3,6-dihydro-1,3,4-thiadiazin-2-one;

[0449] 3-(2-nicotinoylaminobenzyl)-5-(3,4-dimethoxyphenyl)-3,6-dihydro-1,3,4-thiadiazin-2-one;

[0450] 3-(4-nicotinoylaminobenzyl)-5-(3,4-dimethoxyphenyl)-6-ethyl-3,6-dihydro-1,3,4-thiadiazin-2-one;

[0451] 3-(3-nicotinoylaminobenzyl)-5-(3,4-dimethoxyphenyl)-6-ethyl-3,6-dihydro-1,3,4-thiadiazin-2-one;

[0452] 3-(2-nicotinoylaminobenzyl)-5-(3,4-dimethoxyphenyl)-6-ethyl-3,6-dihydro-1,3,4-thiadiazin-2-one;

[0453] 3-(4-nicotinoylaminobenzyl)-5-(3-methoxy-4-trifluoromethoxyphenyl)-6-ethyl-3,6-dihydro-1,3,4-thiadiazin-2-one;

[0454] 3-(4-nicotinoylaminobenzyl)-5-(3-methoxy-4-difluoromethoxyphenyl)-6-ethyl-3,6-dihydro-1,3,4-thiadiazin-2-one;

[0455] 3-(4-nicotinoylaminobenzyl)-5-(3-methoxy-4-fluoromethoxyphenyl)-6-ethyl-3,6-dihydro-1,3,4-thiadiazin-2-one;

[0456] 3-(4-nicotinoylaminobenzyl)-5-(3-difluoromethoxy-4-methoxyphenyl)-6-ethyl-3,6-dihydro-1,3,4-thiadiazin-2-one;

[0457] 3-(4-nicotinoylaminobenzyl)-5-(3-trifluoromethoxy-4-methoxyphenyl)-6-ethyl-3,6-dihydro-1,3,4-thiadiazin-2-one;

[0458] 3-(4-nicotinoylaminobenzyl)-5-(3-fluoromethoxy-4-methoxyphenyl)-6-ethyl-3,6-dihydro-1,3,4-thiadiazin-2-one;

[0459] 3-(4-nicotinoylaminobenzyl)-5-(3-methoxy-4-ethoxyphenyl)-6-ethyl-3,6-dihydro-1,3,4-thiadiazin-2-one;

[0460] 3-(4-nicotinoylaminobenzyl)-5-(3-ethoxy-4-methoxyphenyl)-6-ethyl-3,6-dihydro-1,3,4-thiadiazin-2-one;

[0461] 3-(4-nicotinoylaminobenzyl)-5-(3-hydroxy-4-methoxyphenyl)-6-ethyl-3,6-dihydro-1,3,4-thiadiazin-2-one;

[0462] 3-(4-nicotinoylaminobenzyl)-5-(4-methylsulfonylphenyl)-6-ethyl-3,6-dihydro-1,3,4-thiadiazin-2-one;

[0463] 3-(4-nicotinoylaminobenzyl)-5-(4-methyleneoxyphenyl)-6-ethyl-3,6-dihydro-1,3,4-thiadiazin-2-one;

[0464] 3-(4-nicotinoylaminobenzyl)-5-(3-cyclopentyloxy-4-methoxyphenyl)-6-ethyl-3,6-dihydro-1,3,4-thiadiazin-2-one;

[0465] 3-(3-nicotinoylaminobenzyl)-5-(3-cyclopentyloxy-4-methoxyphenyl)-6-ethyl-3,6-dihydro-1,3,4-thiadiazin-2-one;

[0466] 3-(4-nicotinoylamino-phenethyl)-5-(3,4-dimethoxyphenyl)-3,6-dihydro-1,3,4-thiadiazin-2-one;

[0467] 3-(4-nicotinoylaminophenethyl)-5-(3,4-dimethoxyphenyl)-6-ethyl-3,6-dihydro-1,3,4-thiadiazin-2-one;

[0468] 3-(4-nicotinoylaminobenzyl)-5-(3,4-dimethoxyphenyl)-3,6-dihydro-1,3,4-oxadiazin-2-one;

[0469] 3-(3-nicotinoylaminobenzyl)-5-(3,4-dimethoxyphenyl)-3,6-dihydro-1,3,4-oxadiazin-2-one;

[0470] 3-(2-nicotinoylaminobenzyl)-5-(3,4-dimethoxyphenyl)-3,6-dihydro-1,3,4-oxadiazin-2-one;

[0471] 3-(4-nicotinoylaminobenzyl)-5-(3,4-dimethoxyphenyl)-6-ethyl-3,6-dihydro-1,3,4-oxadiazin-2-one;

[0472] 3-(3-nicotinoylaminobenzyl)-5-(3,4-dimethoxyphenyl)-6-ethyl-3,6-dihydro-1,3,4-oxadiazin-2-one;

[0473] 3-(2-nicotinoylaminobenzyl)-5-(3,4-dimethoxyphenyl)-6-ethyl-3,6-dihydro-1,3,4-oxadiazin-2-one;

[0474] 3-(4-nicotinoylaminobenzyl)-5-(3-methoxy-4-trifluoromethoxyphenyl)-6-ethyl-3,6-dihydro-1,3,4-oxadiazin-2-one;

[0475] 3-(4-nicotinoylaminobenzyl)-5-(3-methoxy-4-difluoromethoxyphenyl)-6-ethyl-3,6-dihydro-1,3,4-oxadiazin-2-one;

[0476] 3-(4-nicotinoylaminobenzyl)-5-(3-methoxy-4-fluoromethoxyphenyl)-6-ethyl-3,6-dihydro-1,3,4-oxadiazin-2-one;

[0477] 3-(4-nicotinoylaminobenzyl)-5-(3-difluoromethoxy-4-methoxyphenyl)-6-ethyl-3,6-dihydro-1,3,4-oxadiazin-2-one;

[0478] 3-(4-nicotinoylaminobenzyl)-5-(3-trifluoromethoxy-4-methoxyphenyl)-6-ethyl-3,6-dihydro-1,3,4-oxadiazin-2-one;

[0479] 3-(4-nicotinoylaminobenzyl)-5-(3-fluoromethoxy-4-methoxyphenyl)-6-ethyl-3,6-dihydro-1,3,4-oxadiazin-2-one;

[0480] 3-(4-nicotinoylaminobenzyl)-5-(3-methoxy-4-ethoxyphenyl)-6-ethyl-3,6-dihydro-1,3,4-oxadiazin-2-one;

[0481] 3-(4-nicotinoylaminobenzyl)-5-(3-ethoxy-4-methoxyphenyl)-6-ethyl-3,6-dihydro-1,3,4-oxadiazin-2-one;

[0482] 3-(4-nicotinoylaminobenzyl)-5-(3-hydroxy-4-methoxyphenyl)-6-ethyl-3,6-dihydro-1,3,4-oxadiazin-2-one;

[0483] 3-(4-nicotinoylaminobenzyl)-5-(4-methylsulfonylphenyl)-6-ethyl-3,6-dihydro-1,3,4-oxadiazin-2-one;

[0484] 3-(4-nicotinoylaminobenzyl)-5-(4-methyleneoxyphenyl)-6-ethyl-3,6-dihydro-1,3,4-oxadiazin-2-one;

[0485] 3-(4-nicotinoylaminobenzyl)-5-(3-cyclopentyloxy-4-methoxyphenyl)-6-ethyl-3,6-dihydro-1,3,4-oxadiazin-2-one;

[0486] 3-(3-nicotinoylaminobenzyl)-5-(3-cyclopentyloxy-4-methoxyphenyl)-6-ethyl-3,6-dihydro-1,3,4-oxadiazin-2-one;

[0487] 3-(4-nicotinoylamino-phenethyl)-5-(3,4-dimethoxyphenyl)-3,6-dihydro-1,3,4-oxadiazin-2-one;

[0488] 3-(4-nicotinoylamino-phenethyl)-5-(3,4-dimethoxyphenyl)-6-ethyl-3,6-dihydro-1,3,4-oxadiazin-2-one;

[0489] 2-(4-isonicotinoylaminobenzyl)-6-(3,4-dimethoxyphenyl)-2,3,4,5-tetrahydropyridazin-3-one;

[0490] 2-(3-isonicotinoylaminobenzyl)-6-(3,4-dimethoxyphenyl)-2,3,4,5-tetrahydropyridazin-3-one;

[0491] 2-(2-isonicotinoylaminobenzyl)-6-(3,4-dimethoxyphenyl)-2,3,4,5-tetrahydropyridazin-3-one;

[0492] 2-(4-isonicotinoylaminobenzyl)-6-(3,4-dimethoxyphenyl)-5-ethyl-2,3,4,5-tetrahydropyridazin-3-one;

[0493] 2-(3-isonicotinoylaminobenzyl)-6-(3,4-dimethoxyphenyl)-5-ethyl-2,3,4,5-tetrahydropyridazin-3-one;

[0494] 2-(2-isonicotinoylaminobenzyl)-6-(3,4-dimethoxyphenyl)-5-ethyl-2,3,4,5-tetrahydropyridazin-3-one;

[0495] 2-(4-isonicotinoylaminobenzyl)-6-(3-methoxy-4-trifluoromethoxyphenyl)-5-ethyl-2,3,4,5-tetrahydropyridazin-3-one;

[0496] 2-(4-isonicotinoylaminobenzyl)-6-(3-methoxy-4-difluoromethoxyphenyl)-5-ethyl-2,3,4,5-tetrahydropyridazin-3-one;

[0497] 2-(4-isonicotinoylaminobenzyl)-6-(3-methoxy-4-fluoromethoxyphenyl)-5-ethyl-2,3,4,5-tetrahydropyridazin-3-one;

[0498] 2-(4-isonicotinoylaminobenzyl)-6-(3-difluoromethoxy-4-methoxyphenyl)-5-ethyl-2,3,4,5-tetrahydropyridazin-3-one;

[0499] 2-(4-isonicotinoylaminobenzyl)-6-(3-trifluoromethoxy-4-methoxyphenyl)-5-ethyl-2,3,4,5-tetrahydropyridazin-3-one;

[0500] 2-(4-isonicotinoylaminobenzyl)-6-(3-fluoromethoxy-4-methoxyphenyl)-5-ethyl-2,3,4,5-tetrahydropyridazin-3-one;

[0501] 2-(4-isonicotinoylaminobenzyl)-6-(3-methoxy-4-ethoxyphenyl)-5-ethyl-2,3,4,5-tetrahydropyridazin-3-one;

[0502] 2-(4-isonicotinoylaminobenzyl)-6-(3-ethoxy-4-methoxyphenyl)-5-ethyl-2,3,4,5-tetrahydropyridazin-3-one;

[0503] 2-(4-isonicotinoylaminobenzyl)-6-(3-hydroxy-4-methoxyphenyl)-5-ethyl-2,3,4,5-tetrahydropyridazin-3-one;

[0504] 2-(4-isonicotinoylaminobenzyl)-6-(4-methylsulfonylphenyl)-5-ethyl-2,3,4,5-tetrahydropyridazin-3-one;

[0505] 2-(4-isonicotinoylaminobenzyl)-6-(4-methyleneoxyphenyl)-5-ethyl-2,3,4,5-tetrahydropyridazin-3-one;

[0506] 2-(4-isonicotinoylaminobenzyl)-6-(3-cyclopentyloxy-4-methoxyphenyl)-5-ethyl-2,3,4,5-tetrahydropyridazin-3-one;

[0507] 2-(3-isonicotinoylaminobenzyl)-6-(3-cyclopentyloxy-4-methoxyphenyl)-5-ethyl-2,3,4,5-tetrahydropyridazin-3-one;

[0508] 2-(4-isonicotinoylaminophenethyl)-6-(3,4-dimethoxyphenyl)-2,3,4,5-tetrahydropyridazin-3-one;

[0509] 2-(4-isonicotinoylaminophenethyl)-6-(3,4-dimethoxyphenyl)-5-ethyl-2,3,4,5-tetrahydropyridazin-3-one;

[0510] 3-(4-isonicotinoylaminobenzyl)-5-(3,4-dimethoxyphenyl)-3,6-dihydro-1,3,4-thiadiazin-2-one;

[0511] 3-(3-isonicotinoylaminobenzyl)-5-(3,4-dimethoxyphenyl)-3,6-dihydro-1,3,4-thiadiazin-2-one;

[0512] 3-(2-isonicotinoylaminobenzyl)-5-(3,4-dimethoxyphenyl)-3,6-dihydro-1,3,4-thiadiazin-2-one;

[0513] 3-(4-isonicotinoylaminobenzyl)-5-(3,4-dimethoxyphenyl)-6-ethyl-3,6-dihydro-1,3,4-thiadiazin-2-one;

[0514] 3-(3-isonicotinoylaminobenzyl)-5-(3,4-dimethoxyphenyl)-6-ethyl-3,6-dihydro-1,3,4-thiadiazin-2-one;

[0515] 3-(2-isonicotinoylaminobenzyl)-5-(3,4-dimethoxyphenyl)-6-ethyl-3,6-dihydro-1,3,4-thiadiazin-2-one;

[0516] 3-(4-isonicotinoylaminobenzyl)-5-(3-methoxy-4-trifluoromethoxyphenyl)-6-ethyl-3,6-dihydro-1,3,4-thiadiazin-2-one;

[0517] 3-(4-isonicotinoylaminobenzyl)-5-(3-methoxy-4-difluoromethoxyphenyl)-6-ethyl-3,6-dihydro-1,3,4-thiadiazin-2-one;

[0518] 3-(4-isonicotinoylaminobenzyl)-5-(3-methoxy-4-fluoromethoxyphenyl)-6-ethyl-3,6-dihydro-1,3,4-thiadiazin-2-one;

[0519] 3-(4-isonicotinoylaminobenzyl)-5-(3-difluoromethoxy-4-methoxyphenyl)-6-ethyl-3,6-dihydro-1,3,4-thiadiazin-2-one;

[0520] 3-(4-isonicotinoylaminobenzyl)-5-(3-trifluoromethoxy-4-methoxyphenyl)-6-ethyl-3,6-dihydro-1,3,4-thiadiazin-2-one;

[0521] 3-(4-nicotinoylaminobenzyl)-5-(3-fluoromethoxy-4-methoxyphenyl)-6-ethyl-3,6-dihydro-1,3,4-thiadiazin-2-one;

[0522] 3-(4-isonicotinoylaminobenzyl)-5-(3-methoxy-4-ethoxyphenyl)-6-ethyl-3,6-dihydro-1,3,4-thiadiazin-2-one;

[0523] 3-(4-isonicotinoylaminobenzyl)-5-(3-ethoxy-4-methoxyphenyl)-6-ethyl-3,6-dihydro-1,3,4-thiadiazin-2-one;

[0524] 3-(4-isonicotinoylaminobenzyl)-5-(3-hydroxy-4-methoxyphenyl)-6-ethyl-3,6-dihydro-1,3,4-thiadiazin-2-one;

[0525] 3-(4-isonicotinoylaminobenzyl)-5-(4-methylsulfonylphenyl)-6-ethyl-3,6-dihydro-1,3,4-thiadiazin-2-one;

[0526] 3-(4-isonicotinoylaminobenzyl)-5-(4-methyleneoxyphenyl)-6-ethyl-3,6-dihydro-1,3,4-thiadiazin-2-one;

[0527] 3-(4-isonicotinoylaminobenzyl)-5-(3-cyclopentyloxy-4-methoxyphenyl)-6-ethyl-3,6-dihydro-1,3,4-thiadiazin-2-one;

[0528] 3-(3-isonicotinoylaminobenzyl)-5-(3-cyclopentyloxy-4-methoxyphenyl)-6-ethyl-3,6-dihydro-1,3,4-thiadiazin-2-one;

[0529] 3-(4-isonicotinoylamino-phenethyl)-5-(3,4-dimethoxyphenyl)-3,6-dihydro-1,3,4-thiadiazin-2-one;

[0530] 3-(4-isonicotinoylaminophenethyl)-5-(3,4-dimethoxyphenyl)-6-ethyl-3,6-dihydro-1,3,4-thiadiazin-2-one;

[0531] 3-(4-isonicotinoylaminobenzyl)-5-(3,4-dimethoxyphenyl)-3,6-dihydro-1,3,4-oxadiazin-2-one;

[0532] 3-(3-isonicotinoylaminobenzyl)-5-(3,4-dimethoxyphenyl)-3,6-dihydro-1,3,4-oxadiazin-2-one;

[0533] 3-(2-isonicotinoylaminobenzyl)-5-(3,4-dimethoxyphenyl)-3,6-dihydro-1,3,4-oxadiazin-2-one;

[0534] 3-(4-isonicotinoylaminobenzyl)-5-(3,4-dimethoxyphenyl)-6-ethyl-3,6-dihydro-1,3,4-oxadiazin-2-one;

[0535] 3-(3-isonicotinoylaminobenzyl)-5-(3,4-dimethoxyphenyl)-6-ethyl-3,6-dihydro-1,3,4-oxadiazin-2-one;

[0536] 3-(2-isonicotinoylaminobenzyl)-5-(3,4-dimethoxyphenyl)-6-ethyl-3,6-dihydro-1,3,4-oxadiazin-2-one;

[0537] 3-(4-isonicotinoylaminobenzyl)-5-(3-methoxy-4-trifluoromethoxyphenyl)-6-ethyl-3,6-dihydro-1,3,4-oxadiazin-2-one;

[0538] 3-(4-isonicotinoylaminobenzyl)-5-(3-methoxy-4-difluoromethoxyphenyl)-6-ethyl-3,6-dihydro-1,3,4-oxadiazin-2-one;

[0539] 3-(4-isonicotinoylaminobenzyl)-5-(3-methoxy-4-fluoromethoxyphenyl)-6-ethyl-3,6-dihydro-1,3,4-oxadiazin-2-one;

[0540] 3-(4-isonicotinoylaminobenzyl)-5-(3-difluoromethoxy-4-methoxyphenyl)-6-ethyl-3,6-dihydro-1,3,4-oxadiazin-2-one;

[0541] 3-(4-isonicotinoylaminobenzyl)-5-(3-trifluoromethoxy-4-methoxyphenyl)-6-ethyl-3,6-dihydro-1,3,4-oxadiazin-2-one;

[0542] 3-(4-isonicotinoylaminobenzyl)-5-(3-fluoromethoxy-4-methoxyphenyl)-6-ethyl-3,6-dihydro-1,3,4-oxadiazin-2-one;

[0543] 3-(4-isonicotinoylaminobenzyl)-5-(3-methoxy-4-ethoxyphenyl)-6-ethyl-3,6-dihydro-1,3,4-oxadiazin-2-one;

[0544] 3-(4-isonicotinoylaminobenzyl)-5-(3-ethoxy-4-methoxyphenyl)-6-ethyl-3,6-dihydro-1,3,4-oxadiazin-2-one;

[0545] 3-(4-isonicotinoylaminobenzyl)-5-(3-hydroxy-4-methoxyphenyl)-6-ethyl-3,6-dihydro-1,3,4-oxadiazin-2-one;

[0546] 3-(4-isonicotinoylaminobenzyl)-5-(4-methylsulfonylphenyl)-6-ethyl-3,6-dihydro-1,3,4-oxadiazin-2-one;

[0547] 3-(4-isonicotinoylaminobenzyl)-5-(4-methyleneoxyphenyl)-6-ethyl-3,6-dihydro-1,3,4-oxadiazin-2-one;

[0548] 3-(4-isonicotinoylaminobenzyl)-5-(3-cyclopentyloxy-4-methoxyphenyl)-6-ethyl-3,6-dihydro-1,3,4-oxadiazin-2-one;

[0549] 3-(3-isonicotinoylaminobenzyl)-5-(3-cyclopentyloxy-4-methoxyphenyl)-6-ethyl-3,6-dihydro-1,3,4-oxadiazin-2-one;

[0550] 3-(4-isonicotinoylamino-phenethyl)-5-(3,4-dimethoxyphenyl)-3,6-dihydro-1,3,4-oxadiazin-2-one;

[0551] 3-(4-isonicotinoylamino-phenethyl)-5-(3,4-dimethoxyphenyl)-6-ethyl-3,6-dihydro-1,3,4-oxadiazin-2-one;

[0552] 2-(4-picolinoylaminobenzyl)-6-(3,4-dimethoxyphenyl)-2,3,4,5-tetrahydropyridazin-3-one;

[0553] 2-(3-picolinoylaminobenzyl)-6-(3,4-dimethoxyphenyl)-2,3,4,5-tetrahydropyridazin-3-one;

[0554] 2-(2-picolinoylaminobenzyl)-6-(3,4-dimethoxyphenyl)-2,3,4,5-tetrahydropyridazin-3-one;

[0555] 2-(4-picolinoylaminobenzyl)-6-(3,4-dimethoxyphenyl)-5-ethyl-2,3,4,5-tetrahydropyridazin-3-one;

[0556] 2-(3-picolinoylaminobenzyl)-6-(3,4-dimethoxyphenyl)-5-ethyl-2,3,4,5-tetrahydropyridazin-3-one;

[0557] 2-(2-picolinoylaminobenzyl)-6-(3,4-dimethoxyphenyl)-5-ethyl-2,3,4,5-tetrahydropyridazin-3-one;

[0558] 2-(4-picolinoylaminobenzyl)-6-(3-methoxy-4-trifluoromethoxyphenyl)-5-ethyl-2,3,4,5-tetrahydropyridazin-3-one;

[0559] 2-(4-picolinoylaminobenzyl)-6-(3-methoxy-4-difluoromethoxyphenyl)-5-ethyl-2,3,4,5-tetrahydropyridazin-3-one;

[0560] 2-(4-picolinoylaminobenzyl)-6-(3-methoxy-4-fluoromethoxyphenyl)-5-ethyl-2,3,4,5-tetrahydropyridazin-3-one;

[0561] 2-(4-picolinoylaminobenzyl)-6-(3-difluoromethoxy-4-methoxyphenyl)-5-ethyl-2,3,4,5-tetrahydropyridazin-3-one;

[0562] 2-(4-picolinoylaminobenzyl)-6-(3-trifluoromethoxy-4-methoxyphenyl)-5-ethyl-2,3,4,5-tetrahydropyridazin-3-one;

[0563] 2-(4-picolinoylaminobenzyl)-6-(3-fluoromethoxy-4-methoxyphenyl)-5-ethyl-2,3,4,5-tetrahydropyridazin-3-one;

[0564] 2-(4-picolinoylaminobenzyl)-6-(3-methoxy-4-ethoxyphenyl)-5-ethyl-2,3,4,5-tetrahydropyridazin-3-one;

[0565] 2-(4-picolinoylaminobenzyl)-6-(3-ethoxy-4-methoxyphenyl)-5-ethyl-2,3,4,5-tetrahydropyridazin-3-one;

[0566] 2-(4-picolinoylaminobenzyl)-6-(3-hydroxy-4-methoxyphenyl)-5-ethyl-2,3,4,5-tetrahydropyridazin-3-one;

[0567] 2-(4-picolinoylaminobenzyl)-6-(4-methylsulfonylphenyl)-5-ethyl-2,3,4,5-tetrahydropyridazin-3-one;

[0568] 2-(4-picolinoylaminobenzyl)-6-(4-methyleneoxyphenyl)-5-ethyl-2,3,4,5-tetrahydropyridazin-3-one;

[0569] 2-(4-picolinoylaminobenzyl)-6-(3-cyclopentyloxy-4-methoxyphenyl)-5-ethyl-2,3,4,5-tetrahydropyridazin-3-one;

[0570] 2-(3-picolinoylaminobenzyl)-6-(3-cyclopentyloxy-4-methoxyphenyl)-5-ethyl-2,3,4,5-tetrahydropyridazin-3-one;

[0571] 2-(4-picolinoylaminophenethyl)-6-(3,4-dimethoxyphenyl)-2,3,4,5-tetrahydropyridazin-3-one;

[0572] 2-(4-picolinoylaminophenethyl)-6-(3,4-dimethoxyphenyl)-5-ethyl-2,3,4,5-tetrahydropyridazin-3-one;

[0573] 3-(4-picolinoylaminobenzyl)-5-(3,4-dimethoxyphenyl)-3,6-dihydro-1,3,4-thiadiazin-2-one;

[0574] 3-(3-picolinoylaminobenzyl)-5-(3,4-dimethoxyphenyl)-3,6-dihydro-1,3,4-thiadiazin-2-one;

[0575] 3-(2-picolinoylaminobenzyl)-5-(3,4-dimethoxyphenyl)-3,6-dihydro-1,3,4-thiadiazin-2-one;

[0576] 3-(4-picolinoylaminobenzyl)-5-(3,4-dimethoxyphenyl)-6-ethyl-3,6-dihydro-1,3,4-thiadiazin-2-one;

[0577] 3-(3-picolinoylaminobenzyl)-5-(3,4-dimethoxyphenyl)-6-ethyl-3,6-dihydro-1,3,4-thiadiazin-2-one;

[0578] 3-(2-picolinoylaminobenzyl)-5-(3,4-dimethoxyphenyl)-6-ethyl-3,6-dihydro-1,3,4-thiadiazin-2-one;

[0579] 3-(4-picolinoylaminobenzyl)-5-(3-methoxy-4-trifluoromethoxyphenyl)-6-ethyl-3,6-dihydro-1,3,4-thiadiazin-2-one;

[0580] 3-(4-picolinoylaminobenzyl)-5-(3-methoxy-4-difluoromethoxyphenyl)-6-ethyl-3,6-dihydro-1,3,4-thiadiazin-2-one;

[0581] 3-(4-picolinoylaminobenzyl)-5-(3-methoxy-4-fluoromethoxyphenyl)-6-ethyl-3,6-dihydro-1,3,4-thiadiazin-2-one;

[0582] 3-(4-picolinoylaminobenzyl)-5-(3-difluoromethoxy-4-methoxyphenyl)-6-ethyl-3,6-dihydro-1,3,4-thiadiazin-2-one;

[0583] 3-(4-picolinoylaminobenzyl)-5-(3-trifluoromethoxy-4-methoxyphenyl)-6-ethyl-3,6-dihydro-1,3,4-thiadiazin-2-one;

[0584] 3-(4-picolinoylaminobenzyl)-5-(3-fluoromethoxy-4-methoxyphenyl)-6-ethyl-3,6-dihydro-1,3,4-thiadiazin-2-one;

[0585] 3-(4-picolinoylaminobenzyl)-5-(3-methoxy-4-ethoxyphenyl)-6-ethyl-3,6-dihydro-1,3,4-thiadiazin-2-one;

[0586] 3-(4-picolinoylaminobenzyl)-5-(3-ethoxy-4-methoxyphenyl)-6-ethyl-3,6-dihydro-1,3,4-thiadiazin-2-one;

[0587] 3-(4-picolinoylaminobenzyl)-5-(3-hydroxy-4-methoxyphenyl)-6-ethyl-3,6-dihydro-1,3,4-thiadiazin-2-one;

[0588] 3-(4-picolinoylaminobenzyl)-5-(4-methylsulfonylphenyl)-6-ethyl-3,6-dihydro-1,3,4-thiadiazin-2-one;

[0589] 3-(4-picolinoylaminobenzyl)-5-(4-methyleneoxyphenyl)-6-ethyl-3,6-dihydro-1,3,4-thiadiazin-2-one;

[0590] 3-(4-picolinoylaminobenzyl)-5-(3-cyclopentyloxy-4-methoxyphenyl)-6-ethyl-3,6-dihydro-1,3,4-thiadiazin-2-one;

[0591] 3-(3-picolinoylaminobenzyl)-5-(3-cyclopentyloxy-4-methoxyphenyl)-6-ethyl-3,6-dihydro-1,3,4-thiadiazin-2-one;

[0592] 3-(4-picolinoylamino-phenethyl)-5-(3,4-dimethoxyphenyl)-3,6-dihydro-1,3,4-thiadiazin-2-one;

[0593] 3-(4-picolinoylaminophenethyl)-5-(3,4-dimethoxyphenyl)-6-ethyl-3,6-dihydro-1,3,4-thiadiazin-2-one;

[0594] 3-(4-picolinoylaminobenzyl)-5-(3,4-dimethoxyphenyl)-3,6-dihydro-1,3,4-oxadiazin-2-one;

[0595] 3-(3-picolinoylaminobenzyl)-5-(3,4-dimethoxyphenyl)-3,6-dihydro-1,3,4-oxadiazin-2-one;

[0596] 3-(2-picolinoylaminobenzyl)-5-(3,4-dimethoxyphenyl)-3,6-dihydro-1,3,4-oxadiazin-2-one;

[0597] 3-(4-picolinoylaminobenzyl)-5-(3,4-dimethoxyphenyl)-6-ethyl-3,6-dihydro-1,3,4-oxadiazin-2-one;

[0598] 3-(3-picolinoylaminobenzyl)-5-(3,4-dimethoxyphenyl)-6-ethyl-3,6-dihydro-1,3,4-oxadiazin-2-one;

[0599] 3-(2-picolinoylaminobenzyl)-5-(3,4-dimethoxyphenyl)-6-ethyl-3,6-dihydro-1,3,4-oxadiazin-2-one;

[0600] 3-(4-picolinoylaminobenzyl)-5-(3-methoxy-4-trifluoromethoxyphenyl)-6-ethyl-3,6-dihydro-1,3,4-oxadiazin-2-one;

[0601] 3-(4-picolinoylaminobenzyl)-5-(3-methoxy-4-difluoromethoxyphenyl)-6-ethyl-3,6-dihydro-1,3,4-oxadiazin-2-one;

[0602] 3-(4-picolinoylaminobenzyl)-5-(3-methoxy-4-fluoromethoxyphenyl)-6-ethyl-3,6-dihydro-1,3,4-oxadiazin-2-one;

[0603] 3-(4-picolinoylaminobenzyl)-5-(3-difluoromethoxy-4-methoxyphenyl)-6-ethyl-3,6-dihydro-1,3,4-oxadiazin-2-one;

[0604] 3-(4-picolinoylaminobenzyl)-5-(3-trifluoromethoxy-4-methoxyphenyl)-6-ethyl-3,6-dihydro-1,3,4-oxadiazin-2-one;

[0605] 3-(4-picolinoylaminobenzyl)-5-(3-fluoromethoxy-4-methoxyphenyl)-6-ethyl-3,6-dihydro-1,3,4-oxadiazin-2-one;

[0606] 3-(4-picolinoylaminobenzyl)-5-(3-methoxy-4-ethoxyphenyl)-6-ethyl-3,6-dihydro-1,3,4-oxadiazin-2-one;

[0607] 3-(4-picolinoylaminobenzyl)-5-(3-ethoxy-4-methoxyphenyl)-6-ethyl-3,6-dihydro-1,3,4-oxadiazin-2-one;

[0608] 3-(4-picolinoylaminobenzyl)-5-(3-hydroxy-4-methoxyphenyl)-6-ethyl-3,6-dihydro-1,3,4-oxadiazin-2-one;

[0609] 3-(4-picolinoylaminobenzyl)-5-(4-methylsulfonylphenyl)-6-ethyl-3,6-dihydro-1,3,4-oxadiazin-2-one;

[0610] 3-(4-picolinoylaminobenzyl)-5-(4-methyleneoxyphenyl)-6-ethyl-3,6-dihydro-1,3,4-oxadiazin-2-one;

[0611] 3-(4-picolinoylaminobenzyl)-5-(3-cyclopentyloxy-4-methoxyphenyl)-6-ethyl-3,6-dihydro-1,3,4-oxadiazin-2-one;

[0612] 3-(3-picolinoylaminobenzyl)-5-(3-cyclopentyloxy-4-methoxyphenyl)-6-ethyl-3,6-dihydro-1,3,4-oxadiazin-2-one;

[0613] 3-(4-picolinoylaminophenethyl)-5-(3,4-dimethoxyphenyl)-3,6-dihydro-1,3,4-oxadiazin-2-one;

[0614] 3-(4-picolinoylaminophenethyl)-5-(3,4-dimethoxyphenyl)-6-ethyl-3,6-dihydro-1,3,4-oxadiazin-2-one;

[0615] 2-(4-(furan-2-carbonylamino)benzyl)-6-(3,4-dimethoxyphenyl)-2,3,4,5-tetrahydropyridazin-3-one;

[0616] 2-(3-(furan-2-carbonylamino)benzyl)-6-(3,4-dimethoxyphenyl)-2,3,4,5-tetrahydropyridazin-3-one;

[0617] 2-(2-(furan-2-carbonylamino)benzyl)-6-(3,4-dimethoxyphenyl)-2,3,4,5-tetrahydropyridazin-3-one;

[0618] 2-(4-(furan-2-carbonylamino)benzyl)-6-(3,4-dimethoxyphenyl)-5-ethyl-2,3,4,5-tetrahydropyridazin-3-one;

[0619] 2-(3-(furan-2-carbonylamino)benzyl)-6-(3,4-dimethoxyphenyl)-5-ethyl-2,3,4,5-tetrahydropyridazin-3-one;

[0620] 2-(2-(furan-2-carbonylamino)benzyl)-6-(3,4-dimethoxyphenyl)-5-ethyl-2,3,4,5-tetrahydropyridazin-3-one;

[0621] 2-(4-(furan-2-carbonylamino)benzyl)-6-(3-methoxy-4-trifluoromethoxyphenyl)-5-ethyl-2,3,4,5-tetrahydropyridazin-3-one;

[0622] 2-(4-(furan-2-carbonylamino)benzyl)-6-(3-methoxy-4-difluoromethoxyphenyl)-5-ethyl-2,3,4,5-tetrahydropyridazin-3-one;

[0623] 2-(4-(furan-2-carbonylamino)benzyl)-6-(3-methoxy-4-fluoromethoxyphenyl)-5-ethyl-2,3,4,5-tetrahydropyridazin-3-one;

[0624] 2-(4-(furan-2-carbonylamino)benzyl)-6-(3-difluoromethoxy-4-methoxyphenyl)-5-ethyl-2,3,4,5-tetrahydropyridazin-3-one;

[0625] 2-(4-(furan-2-carbonylamino)benzyl)-6-(3-trifluoromethoxy-4-methoxyphenyl)-5-ethyl-2,3,4,5-tetrahydropyridazin-3-one;

[0626] 2-(4-(furan-2-carbonylamino)benzyl)-6-(3-fluoromethoxy-4-methoxyphenyl)-5-ethyl-2,3,4,5-tetrahydropyridazin-3-one;

[0627] 2-(4-(furan-2-carbonylamino)benzyl)-6-(3-methoxy-4-ethoxyphenyl)-5-ethyl-2,3,4,5-tetrahydropyridazin-3-one;

[0628] 2-(4-(furan-2-carbonylamino)benzyl)-6-(3-ethoxy-4-methoxyphenyl)-5-ethyl-2,3,4,5-tetrahydropyridazin-3-one;

[0629] 2-(4-(furan-2-carbonylamino)benzyl)-6-(3-hydroxy-4-methoxyphenyl)-5-ethyl-2,3,4,5-tetrahydropyridazin-3-one;

[0630] 2-(4-(furan-2-carbonylamino)benzyl)-6-(4-methylsulfonylphenyl)-5-ethyl-2,3,4,5-tetrahydropyridazin-3-one;

[0631] 2-(4-(furan-2-carbonylamino)benzyl)-6-(4-methyleneoxyphenyl)-5-ethyl-2,3,4,5-tetrahydropyridazin-3-one;

[0632] 2-(4-(furan-2-carbonylamino)benzyl)-6-(3-cyclopentyloxy-4-methoxyphenyl)-5-ethyl-2,3,4,5-tetrahydropyridazin-3-one;

[0633] 2-(3-(furan-2-carbonylamino)benzyl)-6-(3-cyclopentyloxy-4-methoxyphenyl)-5-ethyl-2,3,4,5-tetrahydropyridazin-3-one;

[0634] 2-(4-(furan-2-carbonylamino)phenethyl)-6-(3,4-dimethoxyphenyl)-2,3,4,5-tetrahydropyridazin-3-one;

[0635] 2-(4-(furan-2-carbonylamino)phenethyl)-6-(3,4-dimethoxyphenyl)-5-ethyl-2,3,4,5-tetrahydropyridazin-3-one;

[0636] 3-(4-(furan-2-carbonylamino)benzyl)-5-(3,4-dimethoxyphenyl)-3,6-dihydro-1,3,4-thiadiazin-2-one;

[0637] 3-(3-(furan-2-carbonylamino)benzyl)-5-(3,4-dimethoxyphenyl)-3,6-dihydro-1,3,4-thiadiazin-2-one;

[0638] 3-(2-(furan-2-carbonylamino)benzyl)-5-(3,4-dimethoxyphenyl)-3,6-dihydro-1,3,4-thiadiazin-2-one;

[0639] 3-(4-(furan-2-carbonylamino)benzyl)-5-(3,4-dimethoxyphenyl)-6-ethyl-3,6-dihydro-1,3,4-thiadiazin-2-one;

[0640] 3-(3-(furan-2-carbonylamino)benzyl)-5-(3,4-dimethoxyphenyl)-6-ethyl-3,6-dihydro-1,3,4-thiadiazin-2-one;

[0641] 3-(2-(furan-2-carbonylamino)benzyl)-5-(3,4-dimethoxyphenyl)-6-ethyl-3,6-dihydro-1,3,4-thiadiazin-2-one;

[0642] 3-(4-(furan-2-carbonylamino)benzyl)-5-(3-methoxy-4-trifluoromethoxyphenyl)-6-ethyl-3,6-dihydro-1,3,4-thiadiazin-2-one;

[0643] 3-(4-(furan-2-carbonylamino)benzyl)-5-(3-methoxy-4-difluoromethoxyphenyl)-6-ethyl-3,6-dihydro-1,3,4-thiadiazin-2-one;

[0644] 3-(4-(furan-2-carbonylamino)benzyl)-5-(3-methoxy-4-fluoromethoxyphenyl)-6-ethyl-3,6-dihydro-1,3,4-thiadiazin-2-one;

[0645] 3-(4-(furan-2-carbonylamino)benzyl)-5-(3-difluoromethoxy-4-methoxyphenyl)-6-ethyl-3,6-dihydro-1,3,4-thiadiazin-2-one;

[0646] 3-(4-(furan-2-carbonylamino)benzyl)-5-(3-trifluoromethoxy-4-methoxyphenyl)-6-ethyl-3,6-dihydro-1,3,4-thiadiazin-2-one;

[0647] 3-(4-(furan-2-carbonylamino)benzyl)-5-(3-fluoromethoxy-4-methoxyphenyl)-6-ethyl-3,6-dihydro-1,3,4-thiadiazin-2-one;

[0648] 3-(4-(furan-2-carbonylamino)benzyl)-5-(3-methoxy-4-ethoxyphenyl)-6-ethyl-3,6-dihydro-1,3,4-thiadiazin-2-one;

[0649] 3-(4-(furan-2-carbonylamino)benzyl)-5-(3-ethoxy-4-methoxyphenyl)-6-ethyl-3,6-dihydro-1,3,4-thiadiazin-2-one;

[0650] 3-(4-(furan-2-carbonylamino)benzyl)-5-(3-hydroxy-4-methoxyphenyl)-6-ethyl-3,6-dihydro-1,3,4-thiadiazin-2-one;

[0651] 3-(4-(furan-2-carbonylamino)benzyl)-5-(4-methylsulfonylphenyl)-6-ethyl-3,6-dihydro-1,3,4-thiadiazin-2-one;

[0652] 3-(4-(furan-2-carbonylamino)benzyl)-5-(4-methyleneoxyphenyl)-6-ethyl-3,6-dihydro-1,3,4-thiadiazin-2-one;

[0653] 3-(4-(furan-2-carbonylamino)benzyl)-5-(3-cyciopentyloxy-4-methoxyphenyl)-6-ethyl-3,6-dihydro-1,3,4-thiadiazin-2-one;

[0654] 3-(3-(furan-2-carbonylamino)benzyl)-5-(3-cyclopentyloxy-4-methoxyphenyl)-6-ethyl-3,6-dihydro-1,3,4-thiadiazin-2-one;

[0655] 3-(4-(furan-2-carbonylamino)phenethyl)-5-(3,4-dimethoxyphenyl)-3,6-dihydro-1,3,4-thiadiazin-2-one;

[0656] 3-(4-(furan-2-carbonylamino)phenethyl)-5-(3,4-dimethoxyphenyl)-6-ethyl-3,6-dihydro-1,3,4-thiadiazin-2-one;

[0657] 3-(4-(furan-2-carbonylamino)benzyl)-5-(3,4-dimethoxyphenyl)-3,6-dihydro-1,3,4-oxadiazin-2-one;

[0658] 3-(3-(furan-2-carbonylamino)benzyl)-5-(3,4-dimethoxyphenyl)-3,6-dihydro-1,3,4-oxadiazin-2-one;

[0659] 3-(2-(furan-2-carbonylamino)benzyl)-5-(3,4-dimethoxyphenyl)-3,6-dihydro-1,3,4-oxadiazin-2-one;

[0660] 3-(4-(furan-2-carbonylamino)benzyl)-5-(3,4-dimethoxyphenyl)-6-ethyl-3,6-dihydro-1,3,4-oxadiazin-2-one;

[0661] 3-(3-(furan-2-carbonylamino)benzyl)-5-(3,4-dimethoxyphenyl)-6-ethyl-3,6-dihydro-1,3,4-oxadiazin-2-one;

[0662] 3-(2-(furan-2-carbonylamino)benzyl)-5-(3,4-dimethoxyphenyl)-6-ethyl-3,6-dihydro-1,3,4-oxadiazin-2-one;

[0663] 3-(4-(furan-2-carbonylamino)benzyl)-5-(3-methoxy-4-trifluoromethoxyphenyl)-6-ethyl-3,6-dihydro-1,3,4-oxadiazin-2-one;

[0664] 3-(4-(furan-2-carbonylamino)benzyl)-5-(3-methoxy-4-difluoromethoxyphenyl)-6-ethyl-3,6-dihydro-1,3,4-oxadiazin-2-one;

[0665] 3-(4-(furan-2-carbonylamino)benzyl)-5-(3-methoxy-4-fluoromethoxyphenyl)-6-ethyl-3,6-dihydro-1,3,4-oxadiazin-2-one;

[0666] 3-(4-(furan-2-carbonylamino)benzyl)-5-(3-difluoromethoxy-4-methoxyphenyl)-6-ethyl-3,6-dihydro-1,3,4-oxadiazin-2-one;

[0667] 3-(4-(furan-2-carbonylamino)benzyl)-5-(3-trifluoromethoxy-4-methoxyphenyl)-6-ethyl-3,6-dihydro-1,3,4-oxadiazin-2-one;

[0668] 3-(4-(furan-2-carbonylamino)benzyl)-5-(3-fluoromethoxy-4-methoxyphenyl)-6-ethyl-3,6-dihydro-1,3,4-oxadiazin-2-one;

[0669] 3-(4-(furan-2-carbonylamino)benzyl)-5-(3-methoxy-4-ethoxyphenyl)-6-ethyl-3,6-dihydro-1,3,4-oxadiazin-2-one;

[0670] 3-(4-(furan-2-carbonylamino)benzyl)-5-(3-ethoxy-4-methoxyphenyl)-6-ethyl-3,6-dihydro-1,3,4-oxadiazin-2-one;

[0671] 3-(4-(furan-2-carbonylamino)benzyl)-5-(3-hydroxy-4-methoxyphenyl)-6-ethyl-3,6-dihydro-1,3,4-oxadiazin-2-one;

[0672] 3-(4-(furan-2-carbonylamino)benzyl)-5-(4-methylsulfonylphenyl)-6-ethyl-3,6-dihydro-1,3,4-oxadiazin-2-one;

[0673] 3-(4-(furan-2-carbonylamino)benzyl)-5-(4-methyleneoxyphenyl)-6-ethyl-3,6-dihydro-1,3,4-oxadiazin-2-one;

[0674] 3-(4-(furan-2-carbonylamino)benzyl)-5-(3-cyclopentyloxy-4-methoxyphenyl)-6-ethyl-3,6-dihydro-1,3,4-oxadiazin-2-one;

[0675] 3-(3-(furan-2-carbonylamino)benzyl)-5-(3-cyclopentyloxy-4-methoxyphenyl)-6-ethyl-3,6-dihydro-1,3,4-oxadiazin-2-one;

[0676] 3-(4-(furan-2-carbonylamino)phenethyl)-5-(3,4-dimethoxyphenyl)-3,6-dihydro-1,3,4-oxadiazin-2-one;

[0677] 3-(4-(furan-2-carbonylamino)phenethyl)-5-(3,4-dimethoxyphenyl)-6-ethyl-3,6-dihydro-1,3,4-oxadiazin-2-one;

[0678] 2-(4-(pyrrole-2-carbonylamino)benzyl)-6-(3,4-dimethoxyphenyl)-2,3,4,5-tetrahydropyridazin-3-one;

[0679] 2-(3-(pyrrole-2-carbonylamino)benzyl)-6-(3,4-dimethoxyphenyl)-2,3,4,5-tetrahydropyridazin-3-one;

[0680] 2-(2-(pyrrole-2-carbonylamino)benzyl)-6-(3,4-dimethoxyphenyl)-2,3,4,5-tetrahydropyridazin-3-one;

[0681] 2-(4-(pyrrole-2-carbonylamino)benzyl)-6-(3,4-dimethoxyphenyl)-5-ethyl-2,3,4,5-tetrahydropyridazin-3-one;

[0682] 2-(3-(pyrrole-2-carbonylamino)benzyl)-6-(3,4-dimethoxyphenyl)-5-ethyl-2,3,4,5-tetrahydropyridazin-3-one;

[0683] 2-(2-(pyrrole-2-carbonylamino)benzyl)-6-(3,4-dimethoxyphenyl)-5-ethyl-2,3,4,5-tetrahydropyridazin-3-one;

[0684] 2-(4-(pyrrole-2-carbonylamino)benzyl)-6-(3-methoxy-4-trifluoromethoxyphenyl)-5-ethyl-2,3,4,5-tetrahydropyridazin-3-one;

[0685] 2-(4-(pyrrole-2-carbonylamino)benzyl)-6-(3-methoxy-4-difluoromethoxyphenyl)-5-ethyl-2,3,4,5-tetrahydropyridazin-3-one;

[0686] 2-(4-(pyrrole-2-carbonylamino)benzyl)-6-(3-methoxy-4-fluoromethoxyphenyl)-5-ethyl-2,3,4,5-tetrahydropyridazin-3-one;

[0687] 2-(4-(pyrrole-2-carbonylamino)benzyl)-6-(3-difluoromethoxy-4-methoxyphenyl)-5-ethyl-2,3,4,5-tetrahydropyridazin-3-one;

[0688] 2-(4-(pyrrole-2-carbonylamino)benzyl)-6-(3-trifluoromethoxy-4-methoxyphenyl)-5-ethyl-2,3,4,5-tetrahydropyridazin-3-one;

[0689] 2-(4-(pyrrole-2-carbonylamino)benzyl)-6-(3-fluoromethoxy-4-methoxyphenyl)-5-ethyl-2,3,4,5-tetrahydropyridazin-3-one;

[0690] 2-(4-(pyrrole-2-carbonylamino)benzyl)-6-(3-methoxy-4-ethoxyphenyl)-5-ethyl-2,3,4,5-tetrahydropyridazin-3-one;

[0691] 2-(4-(pyrrole-2-carbonylamino)benzyl)-6-(3-ethoxy-4-methoxyphenyl)-5-ethyl-2,3,4,5-tetrahydropyridazin-3-one;

[0692] 2-(4-(pyrrole-2-carbonylamino)benzyl)-6-(3-hydroxy-4-methoxyphenyl)-5-ethyl-2,3,4,5-tetrahydropyridazin-3-one;

[0693] 2-(4-(pyrrole-2-carbonylamino)benzyl)-6-(4-methylsulfonylphenyl)-5-ethyl-2,3,4,5-tetrahydropyridazin-3-one;

[0694] 2-(4-(pyrrole-2-carbonylamino)benzyl)-6-(4-methyleneoxyphenyl)-5-ethyl-2,3,4,5-tetrahydropyridazin-3-one;

[0695] 2-(4-(pyrrole-2-carbonylamino)benzyl)-6-(3-cyclopentyloxy-4-methoxyphenyl)-5-ethyl-2,3,4,5-tetrahydropyridazin-3-one;

[0696] 2-(3-(pyrrole-2-carbonylamino)benzyl)-6-(3-cyclopentyloxy-4-methoxyphenyl)-5-ethyl-2,3,4,5-tetrahydropyridazin-3-one;

[0697] 2-(4-(pyrrole-2-carbonylamino)phenethyl)-6-(3,4-dimethoxyphenyl)-2,3,4,5-tetrahydropyridazin-3-one;

[0698] 2-(4-(pyrrole-2-carbonylamino)phenethyl)-6-(3,4-dimethoxyphenyl)-5-ethyl-2,3,4,5-tetrahydropyridazin-3-one;

[0699] 3-(4-(pyrrole-2-carbonylamino)benzyl)-5-(3,4-dimethoxyphenyl)-3,6-dihydro-1,3,4-thiadiazin-2-one;

[0700] 3-(3-(pyrrole-2-carbonylamino)benzyl)-5-(3,4-dimethoxyphenyl)-3,6-dihydro-1,3,4-thiadiazin-2-one;

[0701] 3-(2-(pyrrole-2-carbonylamino)benzyl)-5-(3,4-dimethoxyphenyl)-3,6-dihydro-1,3,4-thiadiazin-2-one;

[0702] 3-(4-(pyrrole-2-carbonylamino)benzyl)-5-(3,4-dimethoxyphenyl)-6-ethyl-3,6-dihydro-1,3,4-thiadiazin-2-one;

[0703] 3-(3-(pyrrole-2-carbonylamino)benzyl)-5-(3,4-dimethoxyphenyl)-6-ethyl-3,6-dihydro-1,3,4-thiadiazin-2-one;

[0704] 3-(2-(pyrrole-2-carbonylamino)benzyl)-5-(3,4-dimethoxyphenyl)-6-ethyl-3,6-dihydro-1,3,4-thiadiazin-2-one;

[0705] 3-(4-(pyrrole-2-carbonylamino)benzyl)-5-(3-methoxy-4-trifluoromethoxyphenyl)-6-ethyl-3,6-dihydro-1,3,4-thiadiazin-2-one;

[0706] 3-(4-(pyrrole-2-carbonylamino)benzyl)-5-(3-methoxy-4-difluoromethoxyphenyl)-6-ethyl-3,6-dihydro-1,3,4-thiadiazin-2-one;

[0707] 3-(4-(pyrrole-2-carbonylamino)benzyl)-5-(3-methoxy-4-fluoromethoxyphenyl)-6-ethyl-3,6-dihydro-1,3,4-thiadiazin-2-one;

[0708] 3-(4-(pyrrole-2-carbonylamino)benzyl)-5-(3-difluoromethoxy-4-methoxyphenyl)-6-ethyl-3,6-dihydro-1,3,4-thiadiazin-2-one;

[0709] 3-(4-(pyrrole-2-carbonylamino)benzyl)-5-(3-trifluoromethoxy-4-methoxyphenyl)-6-ethyl-3,6-dihydro-1,3,4-thiadiazin-2-one;

[0710] 3-(4-(pyrrole-2-carbonylamino)benzyl)-5-(3-fluoromethoxy-4-methoxyphenyl)-6-ethyl-3,6-dihydro-1,3,4-thiadiazin-2-one;

[0711] 3-(4-(pyrrole-2-carbonylamino)benzyl)-5-(3-methoxy-4-ethoxyphenyl)-6-ethyl-3,6-dihydro-1,3,4-thiadiazin-2-one;

[0712] 3-(4-(pyrrole-2-carbonylamino)benzyl)-5-(3-ethoxy-4-methoxyphenyl)-6-ethyl-3,6-dihydro-1,3,4-thiadiazin-2-one;

[0713] 3-(4-(pyrrole-2-carbonylamino)benzyl)-5-(3-hydroxy-4-methoxyphenyl)-6-ethyl-3,6-dihydro-1,3,4-thiadiazin-2-one;

[0714] 3-(4-(pyrrole-2-carbonylamino)benzyl)-5-(4-methylsulfonylphenyl)-6-ethyl-3,6-dihydro-1,3,4-thiadiazin-2-one;

[0715] 3-(4-( pyrrole-2-carbonylamino)benzyl)-5-(4-methyleneoxyphenyl)-6-ethyl-3,6-dihydro-1,3,4-thiadiazin-2-one;

[0716] 3-(4-(pyrrole-2-carbonylamino)benzyl)-5-(3-cyclopentyloxy-4-methoxyphenyl)-6-ethyl-3,6-dihydro-1,3,4-thiadiazin-2-one;

[0717] 3-(3-(pyrrole-2-carbonylamino)benzyl)-5-(3-cyclopentyloxy-4-methoxyphenyl)-6-ethyl-3,6-dihydro-1,3,4-thiadiazin-2-one;

[0718] 3-(4-(pyrrole-2-carbonylamino)phenethyl)-5-(3,4-dimethoxyphenyl)-3,6-dihydro-1,3,4-thiadiazin-2-one;

[0719] 3-(4-(pyrrole-2-carbonylamino)phenethyl)-5-(3,4-dimethoxyphenyl)-6-ethyl-3,6-dihydro-1,3,4-thiadiazin-2-one;

[0720] 3-(4-(pyrrole-2-carbonylamino)benzyl)-5-(3,4-dimethoxyphenyl)-3,6-dihydro-1,3,4-oxadiazin-2-one;

[0721] 3-(3-(pyrrole-2-carbonylamino)benzyl)-5-(3,4-dimethoxyphenyl)-3,6-dihydro-1,3,4-oxadiazin-2-one;

[0722] 3-(2-(pyrrole-2-carbonylamino)benzyl)-5-(3,4-dimethoxyphenyl)-3,6-dihydro-1,3,4-oxadiazin-2-one;

[0723] 3-(4-(pyrrole-2-carbonylamino)benzyl)-5-(3,4-dimethoxyphenyl)-6-ethyl-3,6-dihydro-1,3,4-oxadiazin-2-one;

[0724] 3-(3-(pyrrole-2-carbonylamino)benzyl)-5-(3,4-dimethoxyphenyl)-6-ethyl-3,6-dihydro-1,3,4-oxadiazin-2-one;

[0725] 3-(2-(pyrrole-2-carbonylamino)benzyl)-5-(3,4-dimethoxyphenyl)-6-ethyl-3,6-dihydro-1,3,4-oxadiazin-2-one;

[0726] 3-(4-(pyrrole-2-carbonylamino)benzyl)-5-(3-methoxy-4-trifluoromethoxyphenyl)-6-ethyl-3,6-dihydro-1,3,4-oxadiazin-2-one;

[0727] 3-(4-(pyrrole-2-carbonylamino)benzyl)-5-(3-methoxy-4-difluoromethoxyphenyl)-6-ethyl-3,6-dihydro-1,3,4-oxadiazin-2-one;

[0728] 3-(4-(pyrrole-2-carbonylamino)benzyl)-5-(3-methoxy-4-fluoromethoxyphenyl)-6-ethyl-3,6-dihydro-1,3,4-oxadiazin-2-one;

[0729] 3-(4-(pyrrole-2-carbonylamino)benzyl)-5-(3-difluoromethoxy-4-methoxyphenyl)-6-ethyl-3,6-dihydro-1,3,4-oxadiazin-2-one;

[0730] 3-(4-(pyrrole-2-carbonylamino)benzyl)-5-(3-trifluoromethoxy-4-methoxyphenyl)-6-ethyl-3,6-dihydro-1,3,4-oxadiazin-2-one;

[0731] 3-(4-(pyrrole-2-carbonylamino)benzyl)-5-(3-fluoromethoxy-4-methoxyphenyl)-6-ethyl-3,6-dihydro-1,3,4-oxadiazin-2-one;

[0732] 3-(4-(pyrrole-2-carbonylamino)benzyl)-5-(3-methoxy-4-ethoxyphenyl)-6-ethyl-3,6-dihydro-1,3,4-oxadiazin-2-one;

[0733] 3-(4-(pyrrole-2-carbonylamino)benzyl)-5-(3-ethoxy-4-methoxyphenyl)-6-ethyl-3,6-dihydro-1,3,4-oxadiazin-2-one;

[0734] 3-(4-(pyrrole-2-carbonylamino)benzyl)-5-(3-hydroxy-4-methoxyphenyl)-6-ethyl-3,6-dihydro-1,3,4-oxadiazin-2-one;

[0735] 3-(4-(pyrrole-2-carbonylamino)benzyl)-5-(4-methylsulfonylphenyl)-6-ethyl-3,6-dihydro-1,3,4-oxadiazin-2-one;

[0736] 3-(4-(pyrrole-2-carbonylamino)benzyl)-5-(4-methyleneoxyphenyl)-6-ethyl-3,6-dihydro-1,3,4-oxadiazin-2-one;

[0737] 3-(4-(pyrrole-2-carbonylamino)benzyl)-5-(3-cyclopentyloxy-4-methoxyphenyl)-6-ethyl-3,6-dihydro-1,3,4-oxadiazin-2-one;

[0738] 3-(3-(pyrrole-2-carbonylamino)benzyl)-5-(3-cyclopentyloxy-4-methoxyphenyl)-6-ethyl-3,6-dihydro-1,3,4-oxadiazin-2-one;

[0739] 3-(4-(pyrrole-2-carbonylamino)phenethyl)-5-(3,4-dimethoxyphenyl)-3,6-dihydro-1,3,4-oxadiazin-2-one;

[0740] 3-(4-(pyrrole-2-carbonylamino)phenethyl)-5-(3,4-dimethoxyphenyl)-6-ethyl-3,6-dihydro-1,3,4-oxadiazin-2-one;

[0741] 2-(4-(thiophene-2-carbonylamino)benzyl)-6-(3,4-dimethoxyphenyl)-2,3,4,5-tetrahydropyridazin-3-one;

[0742] 2-(3-(thiophene-2-carbonylamino)benzyl)-6-(3,4-dimethoxyphenyl)-2,3,4,5-tetrahydropyridazin-3-one;

[0743] 2-(2-(thiophene-2-carbonylamino)benzyl)-6-(3,4-dimethoxyphenyl)-2,3,4,5-tetrahydropyridazin-3-one;

[0744] 2-(4-(thiophene-2-carbonylamino)benzyl)-6-(3,4-dimethoxyphenyl)-5-ethyl-2,3,4,5-tetrahydropyridazin-3-one;

[0745] 2-(3-(thiophene-2-carbonylamino)benzyl)-6-(3,4-dimethoxyphenyl)-5-ethyl-2,3,4,5-tetrahydropyridazin-3-one;

[0746] 2-(2-(thiophene-2-carbonylamino)benzyl)-6-(3,4-dimethoxyphenyl)-5-ethyl-2,3,4,5-tetrahydropyridazin-3-one;

[0747] 2-(4-(thiophene-2-carbonylamino)benzyl)-6-(3-methoxy-4-trifluoromethoxyphenyl)-5-ethyl-2,3,4,5-tetrahydropyridazin-3-one;

[0748] 2-(4-(thiophene-2-carbonylamino)benzyl)-6-(3-methoxy-4-difluoromethoxyphenyl)-5-ethyl-2,3,4,5-tetrahydropyridazin-3-one;

[0749] 2-(4-(thiophene-2-carbonylamino)benzyl)-6-(3-methoxy-4-fluoromethoxyphenyl)-5-ethyl-2,3,4,5-tetrahydropyridazin-3-one;

[0750] 2-(4-(thiophene-2-carbonylamino)benzyl)-6-(3-difluoromethoxy-4-methoxyphenyl)-5-ethyl-2,3,4,5-tetrahydropyridazin-3-one;

[0751] 2-(4-(thiophene-2-carbonylamino)benzyl)-6-(3-trifluoromethoxy-4-methoxyphenyl)-5-ethyl-2,3,4,5-tetrahydropyridazin-3-one;

[0752] 2-(4-(thiophene-2-carbonylamino)benzyl)-6-(3-fluoromethoxy-4-methoxyphenyl)-5-ethyl-2,3,4,5-tetrahydropyridazin-3-one;

[0753] 2-(4-(thiophene-2-carbonylamino)benzyl)-6-(3-methoxy-4-ethoxyphenyl)-5-ethyl-2,3,4,5-tetrahydropyridazin-3-one;

[0754] 2-(4-(thiophene-2-carbonylamino)benzyl)-6-(3-ethoxy-4-methoxyphenyl)-5-ethyl-2,3,4,5-tetrahydropyridazin-3-one;

[0755] 2-(4-(thiophene-2-carbonylamino)benzyl)-6-(3-hydroxy-4-methoxyphenyl)-5-ethyl-2,3,4,5-tetrahydropyridazin-3-one;

[0756] 2-(4-(thiophene-2-carbonylamino)benzyl)-6-(4-methylsulfonylphenyl)-5-ethyl-2,3,4,5-tetrahydropyridazin-3-one;

[0757] 2-(4-(thiophene-2-carbonylamino)benzyl)-6-(4-methyleneoxyphenyl)-5-ethyl-2,3,4,5-tetrahydropyridazin-3-one;

[0758] 2-(4-(thiophene-2-carbonylamino)benzyl)-6-(3-cyclopentyloxy-4-methoxyphenyl)-5-ethyl-2,3,4,5-tetrahydropyridazin-3-one;

[0759] 2-(3-(thiophene-2-carbonylamino)benzyl)-6-(3-cyclopentyloxy-4-methoxyphenyl)-5-ethyl-2,3,4,5-tetrahydropyridazin-3-one;

[0760] 2-(4-(thiophene-2-carbonylamino)phenethyl)-6-(3,4-dimethoxyphenyl)-2,3,4,5-tetrahydropyridazin-3-one;

[0761] 2-(4-(thiophene-2-carbonylamino)phenethyl)-6-(3,4-dimethoxyphenyl)-5-ethyl-2,3,4,5-tetrahydropyridazin-3-one;

[0762] 3-(4-(thiophene-2-carbonylamino)benzyl)-5-(3,4-dimethoxyphenyl)-3,6-dihydro-1,3,4-thiadiazin-2-one, m.p. 186°;

[0763] 3-(3-(thiophene-2-carbonylamino)benzyl)-5-(3,4-dimethoxyphenyl)-3,6-dihydro-1,3,4-thiadiazin-2-one;

[0764] 3-(2-(thiophene-2-carbonylamino)benzyl)-5-(3,4-dimethoxyphenyl)-3,6-dihydro-1,3,4-thiadiazin-2-one;

[0765] 3-(4-(thiophene-2-carbonylamino)benzyl)-5-(3,4-dimethoxyphenyl)-6-ethyl-3,6-dihydro-1,3,4-thiadiazin-2-one;

[0766] 3-(3-(thiophene-2-carbonylamino)benzyl)-5-(3,4-dimethoxyphenyl)-6-ethyl-3,6-dihydro-1,3,4-thiadiazin-2-one;

[0767] 3-(2-(thiophene-2-carbonylamino)benzyl)-5-(3,4-dimethoxyphenyl)-6-ethyl-3,6-dihydro-1,3,4-thiadiazin-2-one;

[0768] 3-(4-(thiophene-2-carbonylamino)benzyl)-5-(3-methoxy-4-trifluoromethoxyphenyl)-6-ethyl-3,6-dihydro-1,3,4-thiadiazin-2-one;

[0769] 3-(4-(thiophene-2-carbonylamino)benzyl)-5-(3-methoxy-4-difluoromethoxyphenyl)-6-ethyl-3,6-dihydro-1,3,4-thiadiazin-2-one;

[0770] 3-(4-(thiophene-2-carbonylamino)benzyl)-5-(3-methoxy-4-fluoromethoxyphenyl)-6-ethyl-3,6-dihydro-1,3,4-thiadiazin-2-one;

[0771] 3-(4-(thiophene-2-carbonylamino)benzyl)-5-(3-difluoromethoxy-4-methoxyphenyl)-6-ethyl-3,6-dihydro-1,3,4-thiadiazin-2-one;

[0772] 3-(4-(thiophene-2-carbonylamino)benzyl)-5-(3-trifluoromethoxy-4-methoxyphenyl)-6-ethyl-3,6-dihydro-1,3,4-thiadiazin-2-one;

[0773] 3-(4-(thiophene-2-carbonylamino)benzyl)-5-(3-fluoromethoxy-4-methoxyphenyl)-6-ethyl-3,6-dihydro-1,3,4-thiadiazin-2-one;

[0774] 3-(4-(thiophene-2-carbonylamino)benzyl)-5-(3-methoxy-4-ethoxyphenyl)-6-ethyl-3,6-dihydro-1,3,4-thiadiazin-2-one;

[0775] 3-(4-(thiophene-2-carbonylamino)benzyl)-5-(3-ethoxy-4-methoxyphenyl)-6-ethyl-3,6-dihydro-1,3,4-thiadiazin-2-one;

[0776] 3-(4-(thiophene-2-carbonylamino)benzyl)-5-(3-hydroxy-4-methoxyphenyl)-6-ethyl-3,6-dihydro-1,3,4-thiadiazin-2-one;

[0777] 3-(4-(thiophene-2-carbonylamino)benzyl)-5-(4-methylsulfonylphenyl)-6-ethyl-3,6-dihydro-1,3,4-thiadiazin-2-one;

[0778] 3-(4-(thiophene-2-carbonylamino)benzyl)-5-(4-methyleneoxyphenyl)-6-ethyl-3,6-dihydro-1,3,4-thiadiazin-2-one;

[0779] 3-(4-(thiophene-2-carbonylamino)benzyl)-5-(3-cyclopentyloxy-4-methoxyphenyl)-6-ethyl-3,6-dihydro-1,3,4-thiadiazin-2-one;

[0780] 3-(3-(thiophene-2-carbonylamino)benzyl)-5-(3-cyclopentyloxy-4-methoxyphenyl)-6-ethyl-3,6-dihydro-1,3,4-thiadiazin-2-one;

[0781] 3-(4-(thiophene-2-carbonylamino)phenethyl)-5-(3,4-dimethoxyphenyl)-3,6-dihydro-1,3,4-thiadiazin-2-one;

[0782] 3-(4-(thiophene-2-carbonylamino)phenethyl)-5-(3,4-dimethoxyphenyl)-6-ethyl-3,6-dihydro-1,3,4-thiadiazin-2-one;

[0783] 3-(4-(thiophene-2-carbonylamino)benzyl)-5-(3,4-dimethoxyphenyl)-3,6-dihydro-1,3,4-oxadiazin-2-one;

[0784] 3-(3-(thiophene-2-carbonylamino)benzyl)-5-(3,4-dimethoxyphenyl)-3,6-dihydro-1,3,4-oxadiazin-2-one;

[0785] 3-(2-(thiophene-2-carbonylamino)benzyl)-5-(3,4-dimethoxyphenyl)-3,6-dihydro-1,3,4-oxadiazin-2-one;

[0786] 3-(4-(thiophene-2-carbonylamino)benzyl)-5-(3,4-dimethoxyphenyl)-6-ethyl-3,6-dihydro-1,3,4-oxadiazin-2-one;

[0787] 3-(3-(thiophene-2-carbonylamino)benzyl)-5-(3,4-dimethoxyphenyl)-6-ethyl-3,6-dihydro-1,3,4-oxadiazin-2-one;

[0788] 3-(2-(thiophene-2-carbonylamino)benzyl)-5-(3,4-dimethoxyphenyl)-6-ethyl-3,6-dihydro-1,3,4-oxadiazin-2-one;

[0789] 3-(4-(thiophene-2-carbonylamino)benzyl)-5-(3-methoxy-4-trifluoromethoxyphenyl)-6-ethyl-3,6-dihydro-1,3,4-oxadiazin-2-one;

[0790] 3-(4-(thiophene-2-carbonylamino)benzyl)-5-(3-methoxy-4-difluoromethoxyphenyl)-6-ethyl-3,6-dihydro-1,3,4-oxadiazin-2-one;

[0791] 3-(4-(thiophene-2-carbonylamino)benzyl)-5-(3-methoxy-4-fluoromethoxyphenyl)-6-ethyl-3,6-dihydro-1,3,4-oxadiazin-2-one;

[0792] 3-(4-(thiophene-2-carbonylamino)benzyl)-5-(3-difluoromethoxy-4-methoxyphenyl)-6-ethyl-3,6-dihydro-1,3,4-oxadiazin-2-one;

[0793] 3-(4-(thiophene-2-carbonylamino)benzyl)-5-(3-trifluoromethoxy-4-methoxyphenyl)-6-ethyl-3,6-dihydro-1,3,4-oxadiazin-2-one;

[0794] 3-(4-(thiophene-2-carbonylamino)benzyl)-5-(3-fluoromethoxy-4-methoxyphenyl)-6-ethyl-3,6-dihydro-1,3,4-oxadiazin-2-one;

[0795] 3-(4-(thiophene-2-carbonylamino)benzyl)-5-(3-methoxy-4-ethoxyphenyl)-6-ethyl-3,6-dihydro-1,3,4-oxadiazin-2-one;

[0796] 3-(4-(thiophene-2-carbonylamino)benzyl)-5-(3-ethoxy-4-methoxyphenyl)-6-ethyl-3,6-dihydro-1,3,4-oxadiazin-2-one;

[0797] 3-(4-(thiophene-2-carbonylamino)benzyl)-5-(3-hydroxy-4-methoxyphenyl)-6-ethyl-3,6-dihydro-1,3,4-oxadiazin-2-one;

[0798] 3-(4-(thiophene-2-carbonylamino)benzyl)-5-(4-methylsulfonylphenyl)-6-ethyl-3,6-dihydro-1,3,4-oxadiazin-2-one;

[0799] 3-(4-(thiophene-2-carbonylamino)benzyl)-5-(4-methyleneoxyphenyl)-6-ethyl-3,6-dihydro-1,3,4-oxadiazin-2-one;

[0800] 3-(4-(thiophene-2-carbonylamino)benzyl)-5-(3-cyclopentyloxy-4-methoxyphenyl)-6-ethyl-3,6-dihydro-1,3,4-oxadiazin-2-one;

[0801] 3-(3-(thiophene-2-carbonylamino)benzyl)-5-(3-cyclopentyloxy-4-methoxyphenyl)-6-ethyl-3,6-dihydro-1,3,4-oxadiazin-2-one;

[0802] 3-(4-(thiophene-2-carbonylamino)phenethyl)-5-(3,4-dimethoxyphenyl)-3,6-dihydro-1,3,4-oxadiazin-2-one;

[0803] 3-(4-(thiophene-2-carbonylamino)phenethyl)-5-(3,4-dimethoxyphenyl)-6-ethyl-3,6-dihydro-1,3,4-oxadiazin-2-one;

[0804] 2-(4-pyrazinecarbonylaminobenzyl)-6-(3,4-dimethoxyphenyl)-2,3,4,5-tetrahydropyridazin-3-one, m.p. 197°;

[0805] 2-(3-pyrazinecarbonylaminobenzyl)-6-(3,4-dimethoxyphenyl)-2,3,4,5-tetrahydropyridazin-3-one;

[0806] 2-(2-pyrazinecarbonylaminobenzyl)-6-(3,4-dimethoxyphenyl)-2,3,4,5-tetrahydropyridazin-3-one;

[0807] 2-(4-pyrazinecarbonylaminobenzyl)-6-(3,4-dimethoxyphenyl)-5-ethyl-2,3,4,5-tetrahydropyridazin-3-one;

[0808] 2-(3-pyrazinecarbonylaminobenzyi)-6-(3,4-dimethoxyphenyl)-5-ethyl-2,3,4,5-tetrahydropyridazin-3-one;

[0809] 2-(2-pyrazinecarbonylaminobenzyl)-6-(3,4-dimethoxyphenyl)-5-ethyl-2,3,4,5-tetrahydropyridazin-3-one;

[0810] 2-(4-pyrazinecarbonylaminobenzyl)-6-(3-methoxy-4-trifluoromethoxyphenyl)-5-ethyl-2,3,4,5-tetrahydropyridazin-3-one;

[0811] 2-(4-pyrazinecarbonylaminobenzyl)-6-(3-methoxy-4-difluoromethoxyphenyl)-5-ethyl-2,3,4,5-tetrahydropyridazin-3-one;

[0812] 2-(4-pyrazinecarbonylaminobenzyl)-6-(3-methoxy-4-fluoromethoxyphenyl)-5-ethyl-2,3,4,5-tetrahydropyridazin-3-one;

[0813] 2-(4-pyrazinecarbonylaminobenzyl)-6-(3-difluoromethoxy-4-methoxyphenyl)-5-ethyl-2,3,4,5-tetrahydropyridazin-3-one;

[0814] 2-(4-pyrazinecarbonylaminobenzyl)-6-(3-trifluoromethoxy-4-methoxyphenyl)-5-ethyl-2,3,4,5-tetrahydropyridazin-3-one;

[0815] 2-(4-pyrazinecarbonylaminobenzyl)-6-(3-fluoromethoxy-4-methoxyphenyl)-5-ethyl-2,3,4,5-tetrahydropyridazin-3-one;

[0816] 2-(4-pyrazinecarbonylaminobenzyl)-6-(3-methoxy-4-ethoxyphenyl)-5-ethyl-2,3,4,5-tetrahydropyridazin-3-one;

[0817] 2-(4-pyrazinecarbonylaminobenzyl)-6-(3-ethoxy-4-methoxyphenyl)-5-ethyl-2,3,4,5-tetrahydropyridazin-3-one;

[0818] 2-(4-pyrazinecarbonylaminobenzyl)-6-(3-hydroxy-4-methoxyphenyl)-5-ethyl-2,3,4,5-tetrahydropyridazin-3-one;

[0819] 2-(4-pyrazinecarbonylaminobenzyl)-6-(4-methylsulfonylphenyl)-5-ethyl-2,3,4,5-tetrahydropyridazin-3-one;

[0820] 2-(4-pyrazinecarbonylaminobenzyl)-6-(4-methyleneoxyphenyl)-5-ethyl-2,3,4,5-tetrahydropyridazin-3-one;

[0821] 2-(4-pyrazinecarbonylaminobenzyl)-6-(3-cyclopentyloxy-4-methoxyphenyl)-5-ethyl-2,3,4,5-tetrahydropyridazin-3-one;

[0822] 2-(3-pyrazinecarbonylaminobenzyl)-6-(3-cyclopentyloxy-4-methoxyphenyl)-5-ethyl-2,3,4,5-tetrahydropyridazin-3-one;

[0823] 2-(4-pyrazinecarbonylaminophenethyl)-6-(3,4-dimethoxyphenyl)-2,3,4,5-tetrahydropyridazin-3-one;

[0824] 2-(4-pyrazinecarbonylaminophenethyl)-6-(3,4-dimethoxyphenyl)-5-ethyl-2,3,4,5-tetrahydropyridazin-3-one;

[0825] 3-(4-pyrazinecarbonylaminobenzyl)-5-(3,4-dimethoxyphenyl)-3,6-dihydro-1,3,4-thiadiazin-2-one, m.p. 202°;

[0826] 3-(3-pyrazinecarbonylaminobenzyl)-5-(3,4-dimethoxyphenyl)-3,6-dihydro-1,3,4-thiadiazin-2-one;

[0827] 3-(2-pyrazinecarbonylaminobenzyl)-5-(3,4-dimethoxyphenyl)-3,6-dihydro-1,3,4-thiadiazin-2-one;

[0828] 3-(4-pyrazinecarbonylaminobenzyl)-5-(3,4-dimethoxyphenyl)-6-ethyl-3,6-dihydro-1,3,4-thiadiazin-2-one;

[0829] 3-(3-pyrazinecarbonylaminobenzyl)-5-(3,4-dimethoxyphenyl)-6-ethyl-3,6-dihydro-1,3,4-thiadiazin-2-one;

[0830] 3-(2-pyrazinecarbonylaminobenzyl)-5-(3,4-dimethoxyphenyl)-6-ethyl-3,6-dihydro-1,3,4-thiadiazin-2-one;

[0831] 3-(4-pyrazinecarbonylaminobenzyl)-5-(3-methoxy-4-trifluoromethoxyphenyl)-6-ethyl-3,6-dihydro-1,3,4-thiadiazin-2-one;

[0832] 3-(4-pyrazinecarbonylaminobenzyl)-5-(3-methoxy-4-difluoromethoxyphenyl)-6-ethyl-3,6-dihydro-1,3,4-thiadiazin-2-one;

[0833] 3-(4-pyrazinecarbonylaminobenzyl)-5-(3-methoxy-4-fluoromethoxyphenyl)-6-ethyl-3,6-dihydro-1,3,4-thiadiazin-2-one;

[0834] 3-(4-pyrazinecarbonylaminobenzyl)-5-(3-difluoromethoxy-4-methoxyphenyl)-6-ethyl-3,6-dihydro-1,3,4-thiadiazin-2-one,

[0835] 3-(4-pyrazinecarbonylaminobenzyl)-5-(3-trifluoromethoxy-4-methoxyphenyl)-6-ethyl-3,6-dihydro-1,3,4-thiadiazin-2-one;

[0836] 3-(4-pyrazinecarbonylaminobenzyl)-5-(3-fluoromethoxy-4-methoxyphenyl)-6-ethyl-3,6-dihydro-1,3,4-thiadiazin-2-one;

[0837] 3-(4-pyrazinecarbonylaminobenzyl)-5-(3-methoxy-4-ethoxyphenyl)-6-ethyl-3,6-dihydro-1,3,4-thiadiazin-2-one;

[0838] 3-(4-pyrazinecarbonylaminobenzyl)-5-(3-ethoxy-4-methoxyphenyl)-6-ethyl-3,6-dihydro-1,3,4-thiadiazin-2-one;

[0839] 3-(4-pyrazinecarbonylaminobenzyl)-5-(3-hydroxy-4-methoxyphenyl)-6-ethyl-3,6-dihydro-1,3,4-thiadiazin-2-one;

[0840] 3-(4-pyrazinecarbonylaminobenzyl)-5-(4-methylsulfonylphenyl)-6-ethyl-3,6-dihydro-1,3,4-thiadiazin-2-one;

[0841] 3-(4-pyrazinecarbonylaminobenzyl)-5-(4-methyleneoxyphenyl)-6-ethyl-3,6-dihydro-1,3,4-thiadiazin-2-one;

[0842] 3-(4-pyrazinecarbonylaminobenzyl)-5-(3-cyclopentyloxy-4-methoxyphenyl)-6-ethyl-3,6-dihydro-1,3,4-thiadiazin-2-one;

[0843] 3-(3-pyrazinecarbonylaminobenzyl)-5-(3-cyclopentyloxy-4-methoxyphenyl)-6-ethyl-3,6-dihydro-1,3,4-thiadiazin-2-one;

[0844] 3-(4-pyrazinecarbonylamino-phenethyl)-5-(3,4-dimethoxyphenyl)-3,6-dihydro-1,3,4-thiadiazin-2-one;

[0845] 3-(4-pyrazinecarbonylaminophenethyl)-5-(3,4-dimethoxyphenyl)-6-ethyl-3,6-dihydro-1,3,4-thiadiazin-2-one;

[0846] 3-(4-pyrazinecarbonylaminobenzyl)-5-(3,4-dimethoxyphenyl)-3,6-dihydro-1,3,4-oxadiazin-2-one;

[0847] 3-(3-pyrazinecarbonylaminobenzyl)-5-(3,4-dimethoxyphenyl)-3,6-dihydro-1,3,4-oxadiazin-2-one;

[0848] 3-(2-pyrazinecarbonylaminobenzyl)-5-(3,4-dimethoxyphenyl)-3,6-dihydro-1,3,4-oxadiazin-2-one;

[0849] 3-(4-pyrazinecarbonylaminobenzyl)-5-(3,4-dimethoxyphenyl)-6-ethyl-3,6-dihydro-1,3,4-oxadiazin-2-one;

[0850] 3-(3-pyrazinecarbonylaminobenzyl)-5-(3,4-dimethoxyphenyl)-6-ethyl-3,6-dihydro-1,3,4-oxadiazin-2-one;

[0851] 3-(2-pyrazinecarbonylaminobenzyl)-5-(3,4-dimethoxyphenyl)-6-ethyl-3,6-dihydro-1,3,4-oxadiazin-2-one;

[0852] 3-(4-pyrazinecarbonylaminobenzyl)-5-(3-methoxy-4-trifluoromethoxyphenyl)-6-ethyl-3,6-dihydro-1,3,4-oxadiazin-2-one;

[0853] 3-(4-pyrazinecarbonylaminobenzyl)-5-(3-methoxy-4-difluoromethoxyphenyl)-6-ethyl-3,6-dihydro-1,3,4-oxadiazin-2-one,

[0854] 3-(4-pyrazinecarbonylaminobenzyl)-5-(3-methoxy-4-fluoromethoxyphenyl)-6-ethyl-3,6-dihydro-1,3,4-oxadiazin-2-one;

[0855] 3-(4-pyrazinecarbonylaminobenzyl)-5-(3-difluoromethoxy-4-methoxyphenyl)-6-ethyl-3,6-dihydro-1,3,4-oxadiazin-2-one;

[0856] 3-(4-pyrazinecarbonylaminobenzyl)-5-(3-trifluoromethoxy-4-methoxyphenyl)-6-ethyl-3,6-dihydro-1,3,4-oxadiazin-2-one;

[0857] 3-(4-pyrazinecarbonylaminobenzyl)-5-(3-fluoromethoxy-4-methoxyphenyl)-6-ethyl-3,6-dihydro-1,3,4-oxadiazin-2-one;

[0858] 3-(4-pyrazinecarbonylaminobenzyl)-5-(3-methoxy-4-ethoxyphenyl)-6-ethyl-3,6-dihydro-1,3,4-oxadiazin-2-one;

[0859] 3-(4-pyrazinecarbonylaminobenzyl)-5-(3-ethoxy-4-methoxyphenyl)-6-ethyl-3,6-dihydro-1,3,4-oxadiazin-2-one;

[0860] 3-(4-pyrazinecarbonylaminobenzyl)-5-(3-hydroxy-4-methoxyphenyl)-6-ethyl-3,6-dihydro-1,3,4-oxadiazin-2-one;

[0861] 3-(4-pyrazinecarbonylaminobenzyl)-5-(4-methylsulfonylphenyl)-6-ethyl-3,6-dihydro-1,3,4-oxadiazin-2-one;

[0862] 3-(4-pyrazinecarbonylaminobenzyl)-5-(4-methyleneoxyphenyl)-6-ethyl-3,6-dihydro-1,3,4-oxadiazin-2-one;

[0863] 3-(4-pyrazinecarbonylaminobenzyl)-5-(3-cyclopentyloxy-4-methoxyphenyl)-6-ethyl-3,6-dihydro-1,3,4-oxadiazin-2-one;

[0864] 3-(3-pyrazinecarbonylaminobenzyl)-5-(3-cyclopentyloxy-4-methoxyphenyl)-6-ethyl-3,6-dihydro-1,3,4-oxadiazin-2-one;

[0865] 3-(4-pyrazinecarbonylamino-phenethyl)-5-(3,4-dimethoxyphenyl)-3,6-dihydro-1,3,4-oxadiazin-2-one;

[0866] 3-(4-pyrazinecarbonylamino-phenethyl)-5-(3,4-dimethoxyphenyl)-6-ethyl-3,6-dihydro-1,3,4-oxadiazin-2-one;

[0867] 2-(4-(6-chloropyridazine-3-carbonylamino)benzyl)-6-(3,4-dimethoxyphenyl)-2,3,4,5-tetrahydropyridazin-3-one;

[0868] 2-(3-(6-chloropyridazine-3-carbonylamino)benzyl)-6-(3,4-dimethoxyphenyl)-2,3,4,5-tetrahydropyridazin-3-one;

[0869] 2-(2-(6-chloropyridazine-3-carbonylamino)benzyl)-6-(3,4-dimethoxyphenyl)-2,3,4,5-tetrahydropyridazin-3-one;

[0870] 2-(4-(6-chloropyridazine-3-carbonylamino)benzyl)-6-(3,4-dimethoxyphenyl)-5-ethyl-2,3,4,5-tetrahydropyridazin-3-one;

[0871] 2-(3-(6-chloropyridazine-3-carbonylamino)benzyl)-6-(3,4-dimethoxyphenyl)-5-ethyl-2,3,4,5-tetrahydropyridazin-3-one;

[0872] 2-(2-(6-chloropyridazine-3-carbonylamino)benzyl)-6-(3,4-dimethoxyphenyl)-5-ethyl-2,3,4,5-tetrahydropyridazin-3-one;

[0873] 2-(4-(6-chloropyridazine-3-carbonylamino)benzyl)-6-(3-methoxy-4-trifluoromethoxyphenyl)-5-ethyl-2,3,4,5-tetrahydropyridazin-3-one;

[0874] 2-(4-(6-chloropyridazine-3-carbonylamino)benzyl)-6-(3-methoxy-4-difluoromethoxyphenyl)-5-ethyl-2,3,4,5-tetrahydropyridazin-3-one;

[0875] 2-(4-(6-chloropyridazine-3-carbonylamino)benzyl)-6-(3-methoxy-4-fluoromethoxyphenyl)-5-ethyl-2,3,4,5-tetrahydropyridazin-3-one;

[0876] 2-(4-(6-chloropyridazine-3-carbonylamino)benzyl)-6-(3-difluoromethoxy-4-methoxyphenyl)-5-ethyl-2,3,4,5-tetrahydropyridazin-3-one;

[0877] 2-(4-(6-chloropyridazine-3-carbonylamino)benzyl)-6-(3-trifluoromethoxy-4-methoxyphenyl)-5-ethyl-2,3,4,5-tetrahydropyridazin-3-one;

[0878] 2-(4-(6-chloropyridazine-3-carbonylamino)benzyl)-6-(3-fluoromethoxy-4-methoxyphenyl)-5-ethyl-2,3,4,5-tetrahydropyridazin-3-one;

[0879] 2-(4-(6-chloropyridazine-3-carbonylamino)benzyl)-6-(3-methoxy-4-ethoxyphenyl)-5-ethyl-2,3,4,5-tetrahydropyridazin-3-one;

[0880] 2-(4-(6-chloropyridazine-3-carbonylamino)benzyl)-6-(3-ethoxy-4-methoxyphenyl)-5-ethyl-2,3,4,5-tetrahydropyridazin-3-one;

[0881] 2-(4-(6-chloropyridazine-3-carbonylamino)benzyl)-6-(3-hydroxy-4-methoxyphenyl)-5-ethyl-2,3,4,5-tetrahydropyridazin-3-one;

[0882] 2-(4-(6-chloropyridazine-3-carbonylamino)benzyl)-6-(4-methylsulfonylphenyl)-5-ethyl-2,3,4,5-tetrahydropyridazin-3-one;

[0883] 2-(4-(6-chloropyridazine-3-carbonylamino)benzyl)-6-(4-methyleneoxyphenyl)-5-ethyl-2,3,4,5-tetrahydropyridazin-3-one;

[0884] 2-(4-(6-chloropyridazine-3-carbonylamino)benzyl)-6-(3-cyclopentyloxy-4-methoxyphenyl)-5-ethyl-2,3,4,5-tetrahydropyridazin-3-one;

[0885] 2-(3-(6-chloropyridazine-3-carbonylamino)benzyl)-6-(3-cyclopentyloxy-4-methoxyphenyl)-5-ethyl-2,3,4,5-tetrahydropyridazin-3-one;

[0886] 2-(4-(6-chloropyridazine-3-carbonylamino)phenethyl)-6-(3,4-dimethoxyphenyl)-2,3,4,5-tetrahydropyridazin-3-one;

[0887] 2-(4-(6-chloropyridazine-3-carbonylamino)phenethyl)-6-(3,4-dimethoxyphenyl)-5-ethyl-2,3,4,5-tetrahydropyridazin-3-one;

[0888] 3-(4-(6-chloropyridazine-3-carbonylamino)benzyl-5-(3,4-dimethoxyphenyl)-3,6-dihydro-1,3,4-thiadiazin-2-one;

[0889] 3-(3-(6-chloropyridazine-3-carbonylamino)benzyl)-5-(3,4-dimethoxyphenyl)-3,6-dihydro-1,3,4-thiadiazin-2-one;

[0890] 3-(2-(6-chloropyridazine-3-carbonylamino)benzyl)-5-(3,4-dimethoxyphenyl)-3,6-dihydro-1,3,4-thiadiazin-2-one;

[0891] 3-(4-(6-chloropyridazine-3-carbonylamino)benzyl)-5-(3,4-dimethoxyphenyl)-6-ethyl-3,6-dihydro-1,3,4-thiadiazin-2-one;

[0892] 3-(3-(6-chloropyridazine-3-carbonylamino)benzyl)-5-(3,4-dimethoxyphenyl)-6-ethyl-3,6-dihydro-1,3,4-thiadiazin-2-one;

[0893] 3-(2-(6-chloropyridazine-3-carbonylamino)benzyl)-5-(3,4-dimethoxyphenyl)-6-ethyl-3,6-dihydro-1,3,4-thiadiazin-2-one;

[0894] 3-(4-(6-chloropyridazine-3-carbonylamino)benzyl)-5-(3-methoxy-4-trifluoromethoxyphenyl)-6-ethyl-3,6-dihydro-1,3,4-thiadiazin-2-one;

[0895] 3-(4-(6-chloropyridazine-3-carbonylamino)benzyl)-5-(3-methoxy-4-difluoromethoxyphenyl)-6-ethyl-3,6-dihydro-1,3,4-thiadiazin-2-one;

[0896] 3-(4-(6-chloropyridazine-3-carbonylamino)benzyl)-5-(3-methoxy-4-fluoromethoxyphenyl)-6-ethyl-3,6-dihydro-1,3,4-thiadiazin-2-one;

[0897] 3-(4-(6-chloropyridazine-3-carbonylamino)benzyl)-5-(3-difluoromethoxy-4-methoxyphenyl)-6-ethyl-3,6-dihydro-1,3,4-thiadiazin-2-one;

[0898] 3-(4-(6-chloropyridazine-3-carbonylamino)benzyl)-5-(3-trifluoromethoxy-4-methoxyphenyl)-6-ethyl-3,6-dihydro-1,3,4-thiadiazin-2-one;

[0899] 3-(4-(6-chloropyridazine-3-carbonylamino)benzyl)-5-(3-fluoromethoxy-4-methoxyphenyl)-6-ethyl-3,6-dihydro-1,3,4-thiadiazin-2-one;

[0900] 3-(4-(6-chloropyridazine-3-carbonylamino)benzyl)-5-(3-methoxy-4-ethoxyphenyl)-6-ethyl-3,6-dihydro-1,3,4-thiadiazin-2-one;

[0901] 3-(4-(6-chloropyridazine-3-carbonylamino)benzyl)-5-(3-ethoxy-4-methoxyphenyl)-6-ethyl-3,6-dihydro-1,3,4-thiadiazin-2-one;

[0902] 3-(4-(6-chloropyridazine-3-carbonylamino)benzyl)-5-(3-hydroxy-4-methoxyphenyl)-6-ethyl-3,6-dihydro-1,3,4-thiadiazin-2-one;

[0903] 3-(4-(6-chloropyridazine-3-carbonylamino)benzyl)-5-(4-methylsulfonylphenyl)-6-ethyl-3,6-dihydro-1,3,4-thiadiazin-2-one;

[0904] 3-(4-(6-chloropyridazine-3-carbonylamino)benzyl)-5-(4-methyleneoxyphenyl)-6-ethyl-3,6-dihydro-1,3,4-thiadiazin-2-one;

[0905] 3-(4-(6-chloropyridazine-3-carbonylamino)benzyl)-5-(3-cyclopentyloxy-4-methoxyphenyl)-6-ethyl-3,6-dihydro-1,3,4-thiadiazin-2-one;

[0906] 3-(3-(6-chloropyridazine-3-carbonylamino)benzyl)-5-(3-cyclopentyloxy-4-methoxyphenyl)-6-ethyl-3,6-dihydro-1,3,4-thiadiazin-2-one;

[0907] 3-(4-(6-chloropyridazine-3-carbonylamino)phenethyl)-5-(3,4-dimethoxyphenyl)-3,6-dihydro-1,3,4-thiadiazin-2-one;

[0908] 3-(4-(6-chloropyridazine-3-carbonylamino)phenethyl)-5-(3,4-dimethoxyphenyl)-6-ethyl-3,6-dihydro-1,3,4-thiadiazin-2-one;

[0909] 3-(4-(6-chloropyridazine-3-carbonylamino)benzyl)-5-(3,4-dimethoxyphenyl)-3,6-dihydro-1,3,4-oxadiazin-2-one;

[0910] 3-(3-(6-chloropyridazine-3-carbonylamino)benzyl)-5-(3,4-dimethoxyphenyl)-3,6-dihydro-1,3,4-oxadiazin-2-one;

[0911] 3-(2-(6-chloropyridazine-3-carbonylamino)benzyl)-5-(3,4-dimethoxyphenyl)-3,6-dihydro-1,3,4-oxadiazin-2-one;

[0912] 3-(4-(6-chloropyridazine-3-carbonylamino)benzyl)-5-(3,4-dimethoxyphenyl)-6-ethyl-3,6-dihydro-1,3,4-oxadiazin-2-one;

[0913] 3-(3-(6-chloropyridazine-3-carbonylamino)benzyl)-5-(3,4-dimethoxyphenyl)-6-ethyl-3,6-dihydro-1,3,4-oxadiazin-2-one;

[0914] 3-(2-(6-chloropyridazine-3-carbonylamino)benzyl)-5-(3-methoxy-4-trifluoromethoxyphenyl)-6-ethyl-3,6-dihydro-1,3,4-oxadiazin-2-one;

[0915] 3-(4-(6-chloropyridazine-3-carbonylamino)benzyl)-5-(3-methoxy-4-difluoromethoxyphenyl)-6-ethyl-3,6-dihydro-1,3,4-oxadiazin-2-one;

[0916] 3-(4-(6-chloropyridazine-3-carbonylamino)benzyl)-5-(3-methoxy-4-fluoromethoxyphenyl)-6-ethyl-3,6-dihydro-1,3,4-oxadiazin-2-one;

[0917] 3-(4-(6-chloropyridazine-3-carbonylamino)benzyl)-5-(3-difluoromethoxy-4-methoxyphenyl)-6-ethyl-3,6-dihydro-1,3,4-oxadiazin-2-one;

[0918] 3-(4-(6-chloropyridazine-3-carbonylamino)benzyl)-5-(3-trifluoromethoxy-4-methoxyphenyl)-6-ethyl-3,6-dihydro-1,3,4-oxadiazin-2-one;

[0919] 3-(4-(6-chloropyridazine-3-carbonylamino)benzyl)-5-(3-fluoromethoxy-4-methoxyphenyl)-6-ethyl-3,6-dihydro-1,3,4-oxadiazin-2-one;

[0920] 3-(4-(6-chloropyridazine-3-carbonylamino)benzyl)-5-(3-methoxy-4-ethoxyphenyl)-6-ethyl-3,6-dihydro-1,3,4-oxadiazin-2-one;

[0921] 3-(4-(6-chloropyridazine-3-carbonylamino)benzyl)-5-(3-ethoxy-4-methoxyphenyl)-6-ethyl-3,6-dihydro-1,3,4-oxadiazin-2-one;

[0922] 3-(4-(6-chloropyridazine-3-carbonylamino)benzyl)-5-(3-hydroxy-4-methoxyphenyl)-6-ethyl-3,6-dihydro-1,3,4-oxadiazin-2-one;

[0923] 3-(4-(6-chloropyridazine-3-carbonylamino)benzyl)-5-(4-methylsulfonylphenyl)-6-ethyl-3,5-dihydro-1,3,4-oxadiazin-2-one;

[0924] 3-(4-(6-chloropyridazine-3-carbonylamino)benzyl)-5-(4-methyleneoxyphenyl)-6-ethyl-3,6-dihydro-1,3,4-oxadiazin-2-one;

[0925] 3-(4-(6-chloropyridazine-3-carbonylamino)benzyl)-5-(3-cyclopentyloxy-4-methoxyphenyl)-6-ethyl-3,6-dihydro-1,3,4-oxadiazin-2-one;

[0926] 3-(3-(6-chloropyridazine-3-carbonylamino)benzyl)-5-(3-cyclopentyloxy-4-methoxyphenyl)-6-ethyl-3,6-dihydro-1,3,4-oxadiazin-2-one;

[0927] 3-(4-(6-chloropyridazine-3-carbonylamino)phenethyl)-5-(3,4-dimethoxyphenyl)-3,6-dihydro-1,3,4-oxadiazin-2-one;

[0928] 3-(4-(6-chloropyridazine-3-carbonylamino)phenethyl)-5-(3,4-dimethoxyphenyl)-6-ethyl-3,6-dihydro-1,3,4-oxadiazin-2-one;

[0929] 2-(4-(imidazole-4-carbonylamino)benzyl)-6-(3,4-dimethoxyphenyl)-2,3,4,5-tetrahydropyridazin-3-one;

[0930] 2-(3-(imidazole-4-carbonylamino)benzyl)-6-(3,4-dimethoxyphenyl)-2,3,4,5-tetrahydropyridazin-3-one;

[0931] 2-(2-(imidazole-4-carbonylamino)benzyl)-6-(3,4-dimethoxyphenyl)-2,3,4,5-tetrahydropyridazin-3-one;

[0932] 2-(4-(imidazole-4-carbonylamino)benzyl)-6-(3,4-dimethoxyphenyl)-5-ethyl-2,3,4,5-tetrahydropyridazin-3-one;

[0933] 2-(3-(imidazole-4-carbonylamino)benzyl)-6-(3,4-dimethoxyphenyl)-5-ethyl-2,3,4,5-tetrahydropyridazin-3-one;

[0934] 2-(2-(imidazole-4-carbonylamino)benzyl)-6-(3,4-dimethoxyphenyl)-5-ethyl-2,3,4,5-tetrahydropyridazin-3-one;

[0935] 2-(4-(imidazole-4-carbonylamino)benzyl)-6-(3-methoxy-4-trifluoromethoxy-5-ethyl-2,3,4,5-tetrahydropyridazin-3-one;

[0936] 2-(4-(imidazole-4-carbonylamino)benzyl)-6-(3-methoxy-4-difluoromethoxyphenyl)-5-ethyl-2,3,4,5-tetrahydropyridazin-3-one;

[0937] 2-(4-(imidazole-4-carbonylamino)benzyl)-6-(3-methoxy-4-fluoromethoxyphenyl)-5-ethyl-2,3,4,5-tetrahydropyridazin-3-one;

[0938] 2-(4-(imidazole-4-carbonylamino)benzyl)-6-(3-difluoromethoxy-4-methoxyphenyl)-5-ethyl-2,3,4,5-tetrahydropyridazin-3-one;

[0939] 2-(4-(imidazole-4-carbonylamino)benzyl)-6-(3-trifluoromethoxy-4-methoxyphenyl)-5-ethyl-2,3,4,5-tetrahydropyridazin-3-one;

[0940] 2-(4-(imidazole-4-carbonylamino)benzyl)-6-(3-fluoromethoxy-4-methoxyphenyl)-5-ethyl-2,3,4,5-tetrahydropyridazin-3-one;

[0941] 2-(4-(imidazole-4-carbonylamino)benzyl)-6-(3-methoxy-4-ethoxyphenyl)-5-ethyl-2,3,4,5-tetrahydropyridazin-3-one;

[0942] 2-(4-(imidazole-4-carbonylamino)benzyl)-6-(3-ethoxy-4-methoxyphenyl)-5-ethyl-2,3,4,5-tetrahydropyridazin-3-one;

[0943] 2-(4-(imidazole-4-carbonylamino)benzyl)-6-(3-hydroxy-4-methoxyphenyl)-5-ethyl-2,3,4,5-tetrahydropyridazin-3-one;

[0944] 2-(4-(imidazole-4-carbonylamino)benzyl)-6-(4-methylsulfonylphenyl)-5-methyl-2,3,4,5-tetrahydropyridazin-3-one;

[0945] 2-(4-(imidazole-4-carbonylamino)benzyl)-6-(4-methyleneoxyphenyl)-5-ethyl-2,3,4,5-tetrahydropyridazin-3-one;

[0946] 2-(4-(imidazole-4-carbonylamino)benzyl)-6-(3-cyclopentyloxy-4-methoxyphenyl)-5-ethyl-2,3,4,5-tetrahydropyridazin-3-one;

[0947] 2-(3-(imidazole-4-carbonylamino)benzyl)-6-(3-cyclopentyloxy-4-methoxyphenyl)-5-ethyl-2,3,4,5-tetrahydropyridazin-3-one;

[0948] 2-(4-(imidazole-4-carbonylamino)phenethyl)-6-(3,4-dimethoxyphenyl)-2,3,4,5-tetrahydropyridazin-3-one;

[0949] 2-(4-(imidazole-4-carbonylamino)phenethyl)-6-(3,4-dimethoxyphenyl)-5-ethyl-2,3,4,5-tetrahydropyridazin-3-one;

[0950] 3-(4-(imidazole-4-carbonylamino)benzyl)-5-(3,4-dimethoxyphenyl)-3,6-dihydro-1,3,4-thiadiazin-2-one;

[0951] 3-(3-(imidazole-4-carbonylamino)benzyl)-5-(3,4-dimethoxyphenyl)-3,6-dihydro-1,3,4-thiadiazin-2-one;

[0952] 3-(2-(imidazole-4-carbonylamino)benzyl)-5-(3,4-dimethoxyphenyl)-3,6-dihydro-1,3,4-thiadiazin-2-one;

[0953] 3-(4-(imidazole-4-carbonylamino)benzyl)-5-(3,4-dimethoxyphenyl)-6-ethyl-3,6-dihydro-1,3,4-thiadiazin-2-one;

[0954] 3-(3-(imidazole-4-carbonylamino)benzyl)-5-(3,4-dimethoxyphenyl)-6-ethyl-3,6-dihydro-1,3,4-thiadiazin-2-one;

[0955] 3-(2-(imidazole-4-carbonylamino)benzyl)-5-(3,4-dimethoxyphenyl)-6-ethyl-3,6-dihydro-1,3,4-thiadiazin-2-one;

[0956] 3-(4-(imidazole-4-carbonylamino)benzyl)-5-(3-methoxy-4-trifluoromethoxyphenyl)-6-ethyl-3,6-dihydro-1,3,4-thiadiazin-2-one;

[0957] 3-(4-(imidazole-4-carbonylamino)benzyl)-5-(3-methoxy-4-difluoromethoxyphenyl)-6-ethyl-3,6-dihydro-1,3,4-thiadiazin-2-one;

[0958] 3-(4-(imidazole-4-carbonylamino)benzyl)-5-(3-methoxy-4-fluoromethoxyphenyl)-6-ethyl-3,6-dihydro-1,3,4-thiadiazin-2-one;

[0959] 3-(4-(imidazole-4-carbonylamino)benzyl)-5-(3-difluoromethoxy-4-methoxyphenyl)-6-ethyl-3,6-dihydro-1,3,4-thiadiazin-2-one;

[0960] 3-(4-(imidazole-4-carbonylamino)benzyl)-5-(3-trifluoromethoxy-4-methoxyphenyl)-6-ethyl-3,6-dihydro-1,3,4-thiadiazin-2-one;

[0961] 3-(4-(imidazole-4-carbonylamino)benzyl)-5-(3-fluoromethoxy-4-methoxyphenyl)-6-ethyl-3,6-dihydro-1,3,4-thiadiazin-2-one;

[0962] 3-(4-(imidazole-4-carbonylamino)benzyl)-5-(3-methoxy-4-ethoxyphenyl)-6-ethyl-3,6-dihydro-1,3,4-thiadiazin-2-one;

[0963] 3-(4-(imidazole-4-carbonylamino)benzyl)-5-(3-ethoxy-4-methoxyphenyl)-6-ethyl-3,6-dihydro-1,3,4-thiadiazin-2-one;

[0964] 3-(4-(imidazole-4-carbonylamino)benzyl)-5-(3-hydroxy-4-methoxyphenyl)-6-ethyl-3,6-dihydro-1,3,4-thiadiazin-2-one;

[0965] 3-(4-(imidazole-4-carbonylamino)benzyl)-5-(4-methylsulfonylphenyl)-6-ethyl-3,6-dihydro-1,3,4-thiadiazin-2-one;

[0966] 3-(4-(imidazole-4-carbonylamino)benzyl)-5-(4-methyleneoxyphenyl)-6-ethyl-3,6-dihydro-1,3,4-thiadiazin-2-one;

[0967] 3-(4-(imidazole-4-carbonylamino)benzyl)-5-(3-cyclopentyloxy-4-methoxyphenyl)-6-ethyl-3,6-dihydro-1,3,4-thiadiazin-2-one;

[0968] 3-(3-(imidazole-4-carbonylamino)benzyl)-5-(3-cyclopentyloxy-4-methoxyphenyl)-6-ethyl-3,6-dihydro-1,3,4-thiadiazin-2-one;

[0969] 3-(4-(imidazole-4-carbonylamino)phenethyl)-5-(3,4-dimethoxyphenyl)-3,6-dihydro-1,3,4-thiadiazin-2-one;

[0970] 3-(4-(imidazole-4-carbonylamino)phenethyl)-5-(3,4-dimethoxyphenyl)-6-ethyl-3,6-dihydro-1,3,4-thiadiazin-2-one;

[0971] 3-(4-(imidazole-4-carbonylamino)benzyl)-5-(3,4-dimethoxyphenyl)-3,5-dihydro-1,3,4-oxadiazin-2-one;

[0972] 3-(3-(imidazole-4-carbonylamino)benzyl)-5-(3,4-dimethoxyphenyl)-3,6-dihydro-1,3,4-oxadiazin-2-one;

[0973] 3-(2-(imidazole-4-carbonylamino)benzyl)-5-(3,4-dimethoxyphenyl)-3,6-dihydro-1,3,4-oxadiazin-2-one;

[0974] 3-(4-(imidazole-4-carbonylamino)benzyl)-5-(3,4-dimethoxyphenyl)-6-ethyl-3,6-dihydro-1,3,4-oxadiazin-2-one;

[0975] 3-(3-(imidazole-4-carbonylamino)benzyl)-5-(3,4-dimethoxyphenyl)-6-ethyl-3,6-dihydro-1,3,4-oxadiazin-2-one;

[0976] 3-(2-(imidazole-4-carbonylamino)benzyl)-5-(3,4-dimethoxyphenyl)-6-ethyl-3,6-dihydro-1,3,4-oxadiazin-2-one;

[0977] 3-(4-(imidazole-4-carbonylamino)benzyl)-5-(3-methoxy-4-trifluoromethoxyphenyl)-6-ethyl-3,6-dihydro-1,3,4-oxadiazin-2-one;

[0978] 3-(4-(imidazole-4-carbonylamino)benzyl)-5-(3-methoxy-4-difluoromethoxyphenyl)-6-ethyl-3,6-dihydro-1,3,4-oxadiazin-2-one;

[0979] 3-(4-(imidazole-4-carbonylamino)benzyl)-5-(3-methoxy-4-fluoromethoxyphenyl)-6-ethyl-3,6-dihydro-1,3,4-oxadiazin-2-one;

[0980] 3-(4-(imidazole-4-carbonylamino)benzyl)-5-(3-difluoromethoxy-4-methoxyphenyl)-6-ethyl-3,6-dihydro-1,3,4-oxadiazin-2-one;

[0981] 3-(4-(imidazole-4-carbonylamino)benzyl)-5-(3-trifluoromethoxy-4-methoxyphenyl)-6-ethyl-3,6-dihydro-1,3,4-oxadiazin-2-one;

[0982] 3-(4-(imidazole-4-carbonylamino)benzyl)-5-(3-fluoromethoxy-4-methoxyphenyl)-6-ethyl-3,6-dihydro-1,3,4-oxadiazin-2-one;

[0983] 3-(4-(imidazole-4-carbonylamino)benzyl)-5-(3-methoxy-4-ethoxyphenyl)-6-ethyl-3,6-dihydro-1,3,4-oxadiazin-2-one;

[0984] 3-(4-(imidazole-4-carbonylamino)benzyl)-5-(3-ethoxy-4-methoxyphenyl)-6-ethyl-3,6-dihydro-1,3,4-oxadiazin-2-one;

[0985] 3-(4-(imidazole-4-carbonylamino)benzyl)-5-(3-hydroxy-4-methoxyphenyl)-6-ethyl-3,6-dihydro-1,3,4-oxadizin-2-one;

[0986] 3-(4-(imidazole-4-carbonylamino)benzyl)-5-(4-methylsulfonylphenyl)-6-ethyl-3,6-dihydro-1,3,4-oxadiazin-2-one;

[0987] 3-(4-(imidazole-4-carbonylamino)benzyl)-5-(4-methyleneoxyphenyl)-6-ethyl-3,6-dihydro-1,3,4-oxadiazin-2-one;

[0988] 3-(4-(imidazole-4-carbonylamino)benzyl)-5-(3-cyclopentyloxy-4-methoxyphenyl)-6-ethyl-3,6-dihydro-1,3,4-oxadiazin-2-one;

[0989] 3-(3-(imidazole-4-carbonylamino)benzyl)-5-(3-cyclopentyloxy-4-methoxyphenyl)-6-ethyl-3,6-dihydro-1,3,4-oxadiazin-2-one;

[0990] 3-(4-(imidazole-4-carbonylamino)phenethyl)-5-(3,4-dimethoxyphenyl)-3,6-dihydro-1,3,4-oxadiazin-2-one;

[0991] 3-(4-(imidazole-4-carbonylamino)phenethyl)-5-(3,1-dimethoxyphenyl)-6-ethyl-3,6-dihydro-1,3,4-oxadiazin-2-one;

[0992] 2-(4-(2,4-dimethylthiazole-5-carbonylamino)benzyl)-6-(3,4-dimethoxyphenyl)-2,3,4,5-tetrahydropyridazin-3-one;

[0993] 2-(4-(2,4-dimethylthiazole-5-carbonylamino)benzyl)-6-(3,4-dimethoxyphenyl)-2,3,4,5-tetrahydropyridazin-3-one;

[0994] 2-(3-(2,4-dimethylthiazole-5-carbonylamino)benzyl)-6-(3,4-dimethoxyphenyl)-2,3,4,5-tetrahydropyridazin-3-one;

[0995] 2-(4-(2,4-dimethylthiazole-5-carbonylamino)benzyl)-6-(3,4-dimethoxyphenyl)-5-ethyl-2,3,4,5-tetrahydropyridazin-3-one;

[0996] 2-(3-(2,4-dimethylthiazole-5-carbonylamino)benzyl)-6-(3,4-dimethoxyphenyl)-5-ethyl-2,3,4,5-tetrahydropyridazin-3-one;

[0997] 2-(3-(2,4-dimethylthiazole-5-carbonylamino)benzyl)-6-(3,4-dimethoxyphenyl)-5-ethyl-2,3,4,5-tetrahydropyridazin-3-one;

[0998] 2-(2-(2,4-dimethylthiazole-5-carbonylamino)benzyl)-6-(3-methoxy-4-trifluoromethoxyphenyl)-5-ethyl-2,3,4,5-tetrahydropyridazin-3-one;

[0999] 2-(4-(2,4-dimethylthiazole-5-carbonylamino)benzyl)-6-(3-methoxy-4-difluoromethoxyphenyl)-5-ethyl-2,3,4,5-tetrahydropyridazin-3-one;

[1000] 2-(4-(2,4-dimethylthiazole-5-carbonylamino)benzyl)-6-(3-methoxy-4-fluoromethoxyphenyl)-5-ethyl-2,3,4,5-tetrahydropyridazin-3-one;

[1001] 2-(4-(2,4-dimethylthiazole-5-carbonylamino)benzyl)-6-(3-difluoromethoxy-4-methoxyphenyl)-5-ethyl-2,3,4,5-tetrahydropyridazin-3-one;

[1002] 2-(4-(2,4-dimethylthiazole-5-carbonylamino)benzyl)-6-(3-trifluoromethoxy-4-methoxyphenyl)-5-ethyl-2,3,4,5-tetrahydropyridazin-3-one;

[1003] 2-(4-(2,4-dimethylthiazole-5-carbonylamino)benzyl)-6-(3-fluoromethoxy-4-methoxyphenyl)-5-ethyl-2,3,4,5-tetrahydropyridazin-3-one;

[1004] 2-(4-(2,4-dimethylthiazole-5-carbonylamino)benzyl)-6-(3-methoxy-4-ethoxyphenyl)-5-ethyl-2,3,4,5-tetrahydropyridazin-3-one;

[1005] 2-(4-(2,4-dimethylthiazole-5-carbonylamino)benzyl)-6-(3-ethoxy-4-methoxyphenyl)-5-ethyl-2,3,4,5-tetrahydropyridazin-3-one;

[1006] 2-(4-(2,4-dimethylthiazole-5-carbonylamino)benzyl)-6-(3-hydroxy-4-methoxyphenyl)-5-ethyl-2,3,4,5-tetrahydropyridazin-3-one;

[1007] 2-(4-(2,4-dimethylthiazole-5-carbonylamino)benzyl)-6-(4-methylsulfonylphenyl)-5-ethyl-2,3,4,5-tetrahydropyridazin-3-one;

[1008] 2-(4-(2,4-dimethylthiazole-5-carbonylamino)benzyl)-6-(4-methyleneoxyphenyl)-5-ethyl-2,3,4,5-tetrahydropyridazin-3-one;

[1009] 2-(4-(2,4-dimethylthiazole-5-carbonylamino)benzyl)-6-(3-cyclopentyloxy-4-methoxyphenyl)-5-ethyl-2,3,4,5-tetrahydropyridazin-3-one;

[1010] 2-(3-(2,4-dimethylthiazole-5-carbonylamino)benzyl)-6-(3-cyclopentyloxy-4-methoxyphenyl)-5-ethyl-2,3,4,5-tetrahydropyridazin-3-one;

[1011] 2-(4-(2,4-dimethylthiazole-5-carbonylamino)phenethyl)-6-(3,4-dimethoxyphenyl)-2,3,4,5-tetrahydropyridazin-3-one;

[1012] 2-(4-(2,4-dimethylthiazole-5-carbonylamino)phenethyl)-6-(3,4-dimethoxyphenyl)-2,3,4,5-tetrahydropyridazin-3-one;

[1013] 3-(4-(2,4-dimethylthiazole-5-carbonylamino)benzyl)-5-(3,4-dimethoxyphenyl)-3,6-dihydro-1,3,4-thiadiazin-2-one;

[1014] 3-(3-(2,4-dimethylthiazole-5-carbonylamino)benzyl)-5-(3,4-dimethoxyphenyl)-3,6-dihydro-1,3,4-thiadiazin-2-one;

[1015] 3-(2-(2,4-dimethylthiazole-5-carbonylamino)benzyl)-5-(3,4-dimethoxyphenyl)-3,6-dihydro-1,3,4-thiadiazin-2-one;

[1016] 3-(4-(2,4-dimethylthiazole-5-carbonylamino)benzyl)-5-(3,4-dimethoxyphenyl)-6-ethyl-3,6-dihydro-1,3,4-thiadiazin-2-one;

[1017] 3-(3-(2,4-dimethylthiazole-5-carbonylamino)benzyl)-5-(3,4-dimethoxyphenyl)-6-ethyl-3,6-dihydro-1,3,4-thiadiazin-2-one;

[1018] 3-(2-(2,4-dimethylthiazole-5-carbonylamino)benzyl)-5-(3,4-dimethoxyphenyl)-6-ethyl-3,6-dihydro-1,3,4-thiadiazin-2-one;

[1019] 3-(4-(2,4-dimethylthiazole-5-carbonylamino)benzyl)-5-(3-methoxy-4-trifluoromethoxyphenyl)-6-ethyl-3,6-dihydro-1,3,4-thiadiazin-2-one;

[1020] 3-(4-(2,4-dimethylthiazole-5-carbonylamino)benzyl)-5-(3-methoxy-4-difluoromethoxyphenyl)-6-ethyl-3,6-dihydro-1,3,4-thiadiazin-2-one;

[1021] 3-(4-(2,4-dimethylthiazole-5-carbonylamino)benzyl)-5-(3-methoxy-4-fluoromethoxyphenyl)-6-ethyl-3,6-dihydro-1,3,4-thiadiazin-2-one;

[1022] 3-(4-(2,4-dimethylthiazole-5-carbonylamino)benzyl)-5-(3-difluoromethoxy-4-methoxyphenyl)-6-ethyl-3,6-dihydro-1,3,4-thiadiazin-2-one;

[1023] 3-(4-(2,4-dimethylthiazole-5-carbonylamino)benzyl)-5-(3-trifluoromethoxy-4-methoxyphenyl)-6-ethyl-3,6-dihydro-1,3,4-thiadiazin-2-one;

[1024] 3-(4-(2,4-dimethylthiazole-5-carbonylamino)benzyl)-5-(3-fluoromethoxy-4-methoxyphenyl)-6-ethyl-3,6-dihydro-1,3,4-thiadiazin-2-one;

[1025] 3-(4-(2,4-dimethylthiazole-5-carbonylamino)benzyl)-5-(3-methoxy-4-ethoxyphenyl)-6-ethyl-3,6-dihydro-1,3,4-thiadiazin-2-one;

[1026] 3-(4-(2,4-dimethylthiazole-5-carbonylamino)benzyl)-5-(3-ethoxy-4-methoxyphenyl)-6-ethyl-3,6-dihydro-1,3,4-thiadiazin-2-one;

[1027] 3-(4-(2,4-dimethylthiazole-5-carbonylamino)benzyl)-5-(3-hydroxy-4-methoxyphenyl)-6-ethyl-3,6-dihydro-1,3,4-thiadiazin-2-one;

[1028] 3-(4-(2,4-dimethylthiazole-5-carbonylamino)benzyl)-5-(4-methylsulfonylphenyl)-6-ethyl-3,6-dihydro-1,3,4-thiadiazin-2-one;

[1029] 3-(4-(2,4-dimethylthiazole-5-carbonylamino)benzyl)-5-(4-methyleneoxyphenyl)-6-ethyl-3,6-dihydro-1,3,4-thiadiazin-2-one;

[1030] 3-(3-(2,4-dimethylthiazole-5-carbonylamino)benzyl)-5-(3-cyclopentyloxy-4-methoxyphenyl)-6-ethyl-3,6-dihydro-1,3,4-thiadiazin-2-one;

[1031] 3-(4-(2,4-dimethylthiazole-5-carbonylamino)benzyl)-5-(3-cyclopentyloxy-4-methoxyphenyl)-6-ethyl-3,6-dihydro-1,3,4-thiadiazin-2-one;

[1032] 3-(4-(2,4-dimethylthiazole-5-carbonylamino)phenethyl)-5-(3,4-dimethoxyphenyl)-3,6-dihydro-1,3,4-thiadiazin-2-one;

[1033] 3-(4-(2,4-dimethylthiazole-5-carbonylamino)phenethyl)-5-(3,4-dimethoxyphenyl)-6-ethyl-3,6-dihydro-1,3,4-thiadiazin-2-one;

[1034] 3-(4-(2,4-dimethylthiazole-5-carbonylamino)benzyl)-5-(3,4-dimethoxyphenyl)-3,6-dihydro-1,3,4-oxadiazin-2-one;

[1035] 3-(3-(imidazole-4-carbonylamino)benzyl)-5-(3,4-dimethoxyphenyl)-3,6-dihydro-1,3,4-oxadiazin-2-one;

[1036] 3-(2-(2,4-dimethylthiazole-5-carbonylamino)benzyl)-5-(3,4-dimethoxyphenyl)-3,6-dihydro-1,3,4-oxadiazin-2-one;

[1037] 3-(4-(2,4-dimethylthiazole-5-carbonylamino)benzyl)-5-(3,4-dimethoxyphenyl)-6-ethyl-3,4-dihydro-1,3,4-oxadiazin-2-one;

[1038] 3-(3-(2,4-dimethylthiazole-5-carbonylamino)benzyl)-5-(3,4-dimethoxyphenyl)-6-ethyl-3,6-dihydro-1,3,4-oxadiazin-2-one;

[1039] 3-(2-(2,4-dimethylthiazole-5-carbonylamino)benzyl)-5-(3,4-dimethoxyphenyl)-6-ethyl-3,6-dihydro-1,3,4-oxadiazin-2-one;

[1040] 3-(4-(2,4-dimethylthiazole-5-carbonylamino)benzyl)-5-(3-methoxy-4-trifluoromethoxyphenyl)-6-ethyl-3,6-dihydro-1,3,4-oxadiazin-2-one;

[1041] 3-(4-(2,4-dimethylthiazole-5-carbonylamino)benzyl)-5-(3-methoxy-4-difluoromethoxyphenyl)-6-ethyl-3,6-dihydro-1,3,4-oxadiazin-2-one;

[1042] 3-(4-(2,4-dimethylthiazole-5-carbonylamino)benzyl)-5-(3-methoxy-4-fluoromethoxyphenyl)-6-ethyl-3,6-dihydro-1,3,4-oxadiazin-2-one;

[1043] 3-(4-(2,4-dimethylthiazole-5-carbonylamino)benzyl)-5-(3-difluoromethoxy-4-methoxyphenyl)-6-ethyl-3,6-dihydro-1,3,4-oxadiazin-2-one;

[1044] 3-(4-(2,4-dimethylthiazole-5-carbonylamino)benzyl)-5-(3-trifluoromethoxy-4-methoxyphenyl)-6-ethyl-3,6-dihydro-1,3,4-oxadiazin-2-one;

[1045] 3-(4-(2,4-dimethylthiazole-5-carbonylamino)benzyl)-5-(3-fluoromethoxy-4-methoxyphenyl)-6-ethyl-3,6-dihydro-1,3,4-oxadiazin-2-one;

[1046] 3-(4-(2,4-dimethylthiazole-5-carbonylamino)benzyl)-5-(3-methoxy-4-ethoxyphenyl)-6-ethyl-3,6-dihydro-1,3,4-oxadiazin-2-one;

[1047] 3-(4-(2,4-dimethylthiazole-5-carbonylamino)benzyl)-5-(3-ethoxy-4-methoxyphenyl)-6-ethyl-3,6-dihydro-1,3,4-oxadiazin-2-one;

[1048] 3-(4-(2,4-dimethylthiazole-5-carbonylamino)benzyl)-5-(3-hydroxy-4-methoxyphenyl)-6-ethyl-3,6-dihydro-1,3,4-oxadiazin-2-one;

[1049] 3-(4-(2,4-dimethylthiazole-5-carbonylamino)benzyl-5-(4-methylsulfonylphenyl)-6-ethyl-3,6-dihydro-1,3,4-oxadiazin-2-one;

[1050] 3-(4-(2,4-dimethylthiazole-5-carbonylamino)benzyl)-5-(4-methyleneoxyphenyl)-6-ethyl-3,6-dihydro-1,3,4-oxadiazin-2-one;

[1051] 3-(4-(2,4-dimethylthiazole-5-carbonylamino)benzyl)-5-(3-cyclopentyloxy-4-methoxyphenyl)-6-ethyl-3,6-dihydro-1,3,4-oxadiazin-2-one;

[1052] 3-(3-(2,4-dimethylthiazole-5-carbonylamino)benzyl)-5-(3-cyclopentyloxy-4-methoxyphenyl)-6-ethyl-3,6-dihydro-1,3,4-oxadiazin-2-one;

[1053] 3-(4-(2,4-dimethylthiazole-5-carbonylamino)phenethyl)-5-(3,4-dimethoxyphenyl)-3,6-dihydro-1,3,4-oxadiazin-2-one;

[1054] 3-(4-(2,4-dimethylthiazole-5-carbonylamino)phenethyl)-5-(3,4-dimethoxyphenyl)-6-ethyl-3,6-dihydro-1,3,4-oxadiazin-2-one;

[1055] 2-(4-(isoxazole-5-carbonylamino)benzyl)-6-(3,4-dimethoxyphenyl)-2,3,4,5-tetrahydropyridazin-3-one, m.p. 217°;

[1056] 2-(3-(isoxazole-5-carbonylamino)benzyl)-6-(3,4-dimethoxyphenyl)-2,3,4,5-tetrahydropyridazin-3-one;

[1057] 2-(2-(isoxazole-5-carbonylamino)benzyl)-6-(3,4-dimethoxyphenyl)-2,3,4,5-tetrahydropyridazin-3-one;

[1058] 2-(4-(isoxazole-5-carbonylamino)benzyl)-6-(3,4-dimethoxyphenyl)-5-ethyl-2,3,4,5-tetrahydropyridazin-3-one;

[1059] 2-(3-(isoxazole-5-carbonylamino)benzyl)-6-(3,4-dimethoxyphenyl)-5-ethyl-2,3,4,5-tetrahydropyridazin-3-one;

[1060] 2-(2-(isoxazole-5-carbonylamino)benzyl)-6-(3,4-dimethoxyphenyl)-5-ethyl-2,3,4,5-tetrahydropyridazin-3-one;

[1061] 2-(4-(isoxazole-5-carbonylamino)benzyl)-6-(3-methoxy-4-trifluoromethoxyphenyl)-5-ethyl-2,3,4,5-tetrahydropyridazin-3-one;

[1062] 2-(4-(isoxazole-5-carbonylamino)benzyl)-6-(3-methoxy-4-difluoromethoxyphenyl)-5-ethyl-2,3,4,5-tetrahydropyridazin-3-one;

[1063] 2-(4-(isoxazole-5-carbonylamino)benzyl)-6-(3-methoxy-4-fluoromethoxyphenyl)-5-ethyl-2,3,4,5-tetrahydropyridazin-3-one;

[1064] 2-(isoxazole-5-carbonylamino)benzyl)-6-(3-difluoromethoxy-4-methoxyphenyl)-5-ethyl-2,3,4,5-tetrahydropyridazin-3-one;

[1065] 2-(4-(isoxazole-5-carbonylamino)benzyl)-6-(3-trifluoromethoxy-4-methoxyphenyl)-5-ethyl-2,3,4,5-tetrahydropyridazin-3-one;

[1066] 2-(4-(isoxazole-5-carbonylamino)benzyl)-6-(3-fluoromethoxy-4-methoxyphenyl)-5-ethyl-2,3,4,5-tetrahydropyridazin-3-one;

[1067] 2-(4-(isoxazole-5-carbonylamino)benzyl)-6-(3-methoxy-4-ethoxyphenyl)-5-ethyl-2,3,4,5-tetrahydropyridazin-3-one;

[1068] 2-(4-(isoxazole-5-carbonylamino)benzyl)-6-(3-ethoxy-4-methoxyphenyl)-5-ethyl-2,3,4,5-tetrahydropyridazin-3-one;

[1069] 2-(4-(isoxazole-5-carbonylamino)benzyl)-6-(3-hydroxy-4-methoxyphenyl)-5-ethyl-2,3,4,5-tetrahydropyridazin-3-one;

[1070] 2-(4-(isoxazole-5-carbonylamino)benzyl)-6-(4-methylsulfonylphenyl)-5-ethyl-2,3,4,5-tetrahydropyridazin-3-one;

[1071] 2-(4-(isoxazole-5-carbonylamino)benzyl)-6-(4-methyleneoxyphenyl)-5-ethyl-2,3,4,5-tetrahydropyridazin-3-one;

[1072] 2-(4-(isoxazole-5-carbonylamino)benzyl)-6-(3-cyclopentyloxy-4-methoxyphenyl)-5-ethyl-2,3,4,5-tetrahydropyridazin-3-one;

[1073] 2-(3-(isoxazole-5-carbonylamino)benzyl)-6-(3-cyclopentyloxy-4-methoxyphenyl)-5-ethyl-2,3,4,5-tetrahydropyridazin-3-one;

[1074] 2-(4-(isoxazole-5-carbonylamino)phenethyl)-6-(3,4-dimethoxyphenyl)-2,3,4,5-tetrahydropyridazin-3-one;

[1075] 2-(4-(isoxazole-5-carbonylamino)phenethyl)-6-(3,4-dimethoxyphenyl)-5-ethyl-2,3,4,5-tetrahydropyridazin-3-one;

[1076] 3-(4-(isoxazole-5-carbonylamino)benzyl)-5-(3,4-dimethoxyphenyl)-3,6-dihydro-1,3,4-thiadiazin-2-one, m.p. 196°;

[1077] 3-(3-(isoxazole-5-carbonylamino)benzyl)-5-(3,4-dimethoxyphenyl)-3,6-dihydro-1,3,4-thiadiazin-2-one;

[1078] 3-(2-(isoxazole-5-carbonylamino)benzyl)-5-(3,4-dimethoxyphenyl)-3,6-dihydro-1,3,4-thiadiazin-2-one;

[1079] 3-(4-(isoxazole-5-carbonylamino)benzyl)-5-(3,4-dimethoxyphenyl)-6-ethyl-3,6-dihydro-1,3,4-thiadiazin-2-one;

[1080] 3-(3-(isoxazole-5-carbonylamino)benzyl)-5-(3,4-dimethoxyphenyl)-6-ethyl-3,6-dihydro-1,3,4-thiadiazin-2-one;

[1081] 3-(2-(isoxazole-5-carbonylamino)benzyl)-5-(3,4-dimethoxyphenyl)-6-ethyl-3,6-dihydro-1,3,4-thiadiazin-2-one;

[1082] 3-(4-(isoxazole-5-carbonylamino)benzyl)-5-(3-methoxy-4-trifluoromethoxyphenyl)-6-ethyl-3,6-dihydro-1,3,4-thiadiazin-2-one;

[1083] 3-(4-(isoxazole-5-carbonylamino)benzyl)-5-(3-methoxy-4-difluoromethoxyphenyl)-6-ethyl-3,6-dihydro-1,3,4-thiadiazin-2-one;

[1084] 3-(4-(isoxazole-5-carbonylamino)benzyl)-5-(3-methoxy-4-fluoromethoxyphenyl)-6-ethyl-3,6-dihydro-1,3,4-thiadiazin-2-one;

[1085] 3-(4-(isoxazole-5-carbonylamino)benzyl)-5-(3-difluoromethoxy-4-methoxyphenyl)-6-ethyl-3,6-dihydro-1,3,4-thiadiazin-2-one;

[1086] 3-(4-(isoxazole-5-carbonylamino)benzyl)-5-(3-trifluoromethoxy-4-methoxyphenyl)-6-ethyl-3,6-dihydro-1,3,4-thiadiazin-2-one;

[1087] 3-(4-(isoxazole-5-carbonylamino)benzyl)-5-(3-fluoromethoxy-4-methoxyphenyl)-6-ethyl-3,6-dihydro-1,3,4-thiadiazin-2-one;

[1088] 3-(4-(isoxazole-5-carbonylamino)benzyl)-5-(3-methoxy-4-ethoxyphenyl)-6-ethyl-3,6-dihydro-1,3,4-thiadiazin-2-one;

[1089] 3-(4-(isoxazole-5-carbonylamino)benzyl)-5-(3-ethoxy-4-methoxyphenyl)-6-ethyl-3,6-dihydro-1,3,4-thiadiazin-2-one;

[1090] 3-(4-(isoxazole-5-carbonylamino)benzyl)-5-(3-hydroxy-4-methoxyphenyl)-6-ethyl-3,6-dihydro-1,3,4-thiadiazin-2-one;

[1091] 3-(4-(isoxazole-5-carbonylamino)benzyl)-5-(4-methylsulfonylphenyl)-6-ethyl-3,6-dihydro-1,3,4-thiadiazin-2-one;

[1092] 3-(4-(isoxazole-5-carbonylamino)benzyl)-5-(4-methyleneoxyphenyl)-6-ethyl-3,6-dihydro-1,3,4-thiadiazin-2-one;

[1093] 3-(4-(isoxazole-5-carbonylamino)benzyl)-5-(3-cyclopentyloxy-4-methoxyphenyl)-6-ethyl-3,6-dihydro-1,3,4-thiadiazin-2-one;

[1094] 3-(3-(isoxazole-5-carbonylamino)benzyl)-5-(3-cyclopentyloxy-4-methoxyphenyl)-6-ethyl-3,6-dihydro-1,3,4-thiadiazin-2-one;

[1095] 3-(4-(isoxazole-5-carbonylamino)phenethyl)-5-(3,4-dimethoxyphenyl)-3,6-dihydro-1,3,4-thiadiazin-2-one;

[1096] 3-(4-(isoxazole-5-carbonylamino)phenethyl)-5-(3,4-dimethoxyphenyl)-6-ethyl-3,6-dihydro-1,3,4-thiadiazin-2-one;

[1097] 3-(4-(isoxazole-5-carbonylamino)benzyl)-5-(3,4-dimethoxyphenyl)-3,6-dihydro-1,3,4-oxadiazin-2-one;

[1098] 3-(3-(isoxazole-5-carbonylamino)benzyl)-5-(3,4-dimethoxyphenyl)-3,6-dihydro-1,3,4-oxadiazin-2-one;

[1099] 3-(2-(isoxazole-5-carbonylamino)benzyl)-5-(3,4-dimethoxyphenyl)-3,6-dihydro-1,3,4-oxadiazin-2-one;

[1100] 3-(4-(isoxazole-5-carbonylamino)benzyl)-5-(3,4-dimethoxyphenyl)-6-ethyl-3,6-dihydro-1,3,4-oxadiazin-2-one;

[1101] 3-(3-(isoxazole-5-carbonylamino)benzyl)-5-(3,4-dimethoxyphenyl)-6-ethyl-3,6-dihydro-1,3,4-oxadiazin-2-one;

[1102] 3-(2-(isoxazole-5-carbonylamino)benzyl)-5-(3,4-dimethoxyphenyl)-6-ethyl-3,6-dihydro-1,3,4-oxadiazin-2-one;

[1103] 3-(4-(isoxazole-5-carbonylamino)benzyl)-5-(3-methoxy-4-trifluoromethoxyphenyl)-6-ethyl-3,6-dihydro-1,3,4-oxadiazin-2-one;

[1104] 3-(4-(isoxazole-5-carbonylamino)benzyl)-5-(3-methoxy-4-difluoromethoxyphenyl)-6-ethyl-3,6-dihydro-1,3,4-oxadiazin-2-one;

[1105] 3-(4-(isoxazole-5-carbonylamino)benzyl)-5-(3-methoxy-4-fluoromethoxyphenyl)-6-ethyl-3,6-dihydro-1,3,4-oxadiazin-2-one;

[1106] 3-(4-(isoxazole-5-carbonylamino)benzyl)-5-(3-difluoromethoxy-4-methoxyphenyl)-6-ethyl-3,6-dihydro-1,3,4-oxadiazin-2-one;

[1107] 3-(4-(isoxazole-5-carbonylamino)benzyl)-5-(3-trifluoromethoxy-4-methoxyphenyl)-6-ethyl-3,6-dihydro-1,3,4-oxadiazin-2-one;

[1108] 3-(4-(isoxazole-5-carbonylamino)benzyl)-5-(3-fluoromethoxy-4-methoxyphenyl)-6-ethyl-3,6-dihydro-1,3,4-oxadiazin-2-one;

[1109] 3-(4-(isoxazole-5-carbonylamino)benzyl)-5-(3-methoxy-4-ethoxyphenyl)-6-ethyl-3,6-dihydro-1,3,4-oxadiazin-2-one;

[1110] 3-(4-(isoxazole-5-carbonylamino)benzyl)-5-(3-ethoxy-4-methoxyphenyl)-6-ethyl-3,6-dihydro-1,3,4-oxadiazin-2-one;

[1111] 3-(4-(isoxazole-5-carbonylamino)benzyl)-5-(3-hydroxy-4-methoxyphenyl)-6-ethyl-3,6-dihydro-1,3,4-oxadiazin-2-one;

[1112] 3-(4-(isoxazole-5-carbonylamino)benzyl)-5-(4-methylsulfonylphenyl)-6-ethyl-3,6-dihydro-1,3,4-oxadiazin-2-one;

[1113] 3-(4-(isoxazole-5-carbonylamino)benzyl)-5-(4-methyleneoxyphenyl)-6-ethyl-3,6-dihydro-1,3,4-oxadiazin-2-one;

[1114] 3-(4-(isoxazole-5-carbonylamino)benzyl)-5-(3-cyclopentyloxy-4-methoxyphenyl)-6-ethyl-3,6-dihydro-1,3,4-oxadiazin-2-one;

[1115] 3-(4-(isoxazole-5-carbonylamino)benzyl)-5-(3-cyclopentyloxy-4-methoxyphenyl)-6-ethyl-3,6-dihydro-1,3,4-oxadiazin-2-one;

[1116] 3-(4-(isoxazole-5-carbonylamino)phenethyl)-5-(3,4-dimethoxyphenyl)-3,6-dihydro-1,3,4-oxadiazin-2-one;

[1117] 3-(4-(isoxazole-5-carbonylamino)phenethyl)-5-(3,4-dimethoxyphenyl)-6-ethyl-3,6-dihydro-1,3,4-oxadiazin-2-one;

[1118] 2-(4-(oxazole-5-carbonylamino)benzyl)-6-(3,4-dimethoxyphenyl)-2,3,4,5-tetrahydropyridazin-3-one;

[1119] 2-(3-(oxazole-5-carbonylamino)benzyl)-6-(3,4-dimethoxyphenyl)-2,3,4,5-tetrahydropyridazin-3-one;

[1120] 2-(2-(oxazole-5-carbonylamino)benzyl)-6-(3,4-dimethoxyphenyl)-2,3,4,5-tetrahydropyridazin-3-one;

[1121] 2-(4-(oxazole-5-carbonylamino)benzyl)-6-(3,4-dimethoxyphenyl)-5-ethyl-2,3,4,5-tetrahydropyridazin-3-one;

[1122] 2-(3-(oxazole-5-carbonylamino)benzyl)-6-(3,4-dimethoxyphenyl)-5-ethyl-2,3,4,5-tetrahydropyridazin-3-one;

[1123] 2-(2-(oxazole-5-carbonylamino)benzyl)-6-(3,4-dimethoxyphenyl)-5-ethyl-2,3,4,5-tetrahydropyridazin-3-one;

[1124] 2-(4-(oxazole-5-carbonylamino)benzyl)-6-(3-methoxy-4-trifluoromethoxyphenyl)-5-ethyl-2,3,4,5-tetrahydropyridazin-3-one;

[1125] 2-(4-(oxazole-5-carbonylamino)benzyl)-6-(3-methoxy-4-difluoromethoxyphenyl)-5-ethyl-2,3,4,5-tetrahydropyridazin-3-one;

[1126] 2-(4-(oxazole-5-carbonylamino)benzyl)-6-(3-methoxy-4-fluoromethoxyphenyl)-5-ethyl-2,3,4,5-tetrahydropyridazin-3-one;

[1127] 2-(4-(oxazole-5-carbonylamino)benzyl)-6-(3-difluoromethoxy-4-methoxyphenyl)-5-ethyl-2,3,4,5-tetrahydropyridazin-3-one;

[1128] 2-(4-(oxazole-5-carbonylamino)benzyl)-6-(3-trifluoromethoxy-4-methoxyphenyl)-5-ethyl-2,3,4,5-tetrahydropyridazin-3-one;

[1129] 2-(4-(oxazole-5-carbonylamino)benzyl)-6-(3-fluoromethoxy-4-methoxyphenyl)-5-ethyl-2,3,4,5-tetrahydropyridazin-3-one;

[1130] 2-(4-(oxazole-5-carbonylamino)benzyl)-6-(3-methoxy-4-ethoxyphenyl)-5-ethyl-2,3,4,5-tetrahydropyridazin-3-one;

[1131] 2-(4-(oxazole-5-carbonylamino)benzyl)-6-(3-ethoxy-4-methoxyphenyl)-5-ethyl-2,3,4,5-tetrahydropyridazin-3-one;

[1132] 2-(4-(oxazole-5-carbonylamino)benzyl)-6-(3-hydroxy-4-methoxyphenyl)-5-ethyl-2,3,4,5-tetrahydropyridazin-3-one;

[1133] 2-(4-(oxazole-5-carbonylamino)benzyl)-6-(4-methylsulfonylphenyl)-5-ethyl-2,3,4,5-tetrahydropyridazin-3-one;

[1134] 2-(4-(oxazole-5-carbonylamino)benzyl)-6-(4-methyleneoxyphenyl)-5-ethyl-2,3,4,5-tetrahydropyridazin-3-one;

[1135] 2-(4-(oxazole-5-carbonylamino)benzyl)-6-(3-cyclopentyloxy-4-methoxyphenyl)-5-ethyl-2,3,4,5-tetrahydropyridazin-3-one;

[1136] 2-(3-(oxazole-5-carbonylamino)benzyl)-6-(3-cyclopentyloxy-4-methoxyphenyl)-5-ethyl-2,3,4,5-tetrahydropyridazin-3-one;

[1137] 2-(4-(oxazole-5-carbonylamino)phenethyl)-6-(3,4-dimethoxyphenyl)-2,3,4,5-tetrahydropyridazin-3-one;

[1138] 2-(4-(oxazole-5-carbonylamino)phenethyl)-6-(3,4-dimethoxyphenyl)-5-ethyl-2,3,4,5-tetrahydropyridazin-3-one;

[1139] 3-(4-(oxazole-5-carbonylamino)benzyl)-5-(3,4-dimethoxyphenyl)-3,6-dihydro-1,3,4-thiadiazin-2-one;

[1140] 3-(3-(oxazole-5-carbonylamino)benzyl)-5-(3,4-dimethoxyphenyl)-3,6-dihydro-1,3,4-thiadiazin-2-one;

[1141] 3-(2-(oxazole-5-carbonylamino)benzyl)-5-(3,4-dimethoxyphenyl)-3,6-dihydro-1,3,4-thiadiazin-2-one;

[1142] 3-(4-(oxazole-5-carbonylamino)benzyl)-5-(3,4-dimethoxyphenyl)-6-ethyl-3,6-dihydro-1,3,4-thiadiazin-2-one;

[1143] 3-(3-(oxazole-5-carbonylamino)benzyl)-5-(3,4-dimethoxyphenyl)-6-ethyl-3,6-dihydro-1,3,4-thiadiazin-2-one;

[1144] 3-(2-(oxazole-5-carbonylamino)benzyl)-5-(3,4-dimethoxyphenyl)-6-ethyl-3,6-dihydro-1,3,4-thiadiazin-2-one;

[1145] 3-(4-(oxazole-5-carbonylamino)benzyl)-5-(3-methoxy-4-trifluoromethoxyphenyl)-6-ethyl-3,6-dihydro-1,3,4-thiadiazin-2-one;

[1146] 3-(4-(oxazole-5-carbonylamino)benzyl)-5-(3-methoxy-4-difluoromethoxyphenyl)-6-ethyl-3,6-dihydro-1,3,4-thiadiazin-2-one;

[1147] 3-(4-(oxazole-5-carbonylamino)benzyl)-5-(3-methoxy-4-fluoromethoxyphenyl)-6-ethyl-3,6-dihydro-1,3,4-thiadiazin-2-one;

[1148] 3-(4-(oxazole-5-carbonylamino)benzyl)-5-(3-difluoromethoxy-4-methoxyphenyl)-6-ethyl-3,6-dihydro-1,3,4-thiadiazin-2-one;

[1149] 3-(4-(oxazole-5-carbonylamino)benzyl)-5-(3-trifluoromethoxy-4-methoxyphenyl)-6-ethyl-3,6-dihydro-1,3,4-thiadiazin-2-one;

[1150] 3-(4-(oxazole-5-carbonylamino)benzyl)-5-(3-fluoromethoxy-4-methoxyphenyl)-6-ethyl-3,6-dihydro-1,3,4-thiadiazin-2-one;

[1151] 3-(4-(oxazole-5-carbonylamino)benzyl)-5-(3-methoxy-4-ethoxyphenyl)-6-ethyl-3,6-dihydro-1,3,4-thiadiazin-2-one;

[1152] 3-(4-(oxazole-5-carbonylamino)benzyl)-5-(3-ethoxy-4-methoxyphenyl)-6-ethyl-3,6-dihydro-1,3,4-thiadiazin-2-one;

[1153] 3-(4-(oxazole-5-carbonylamino)benzyl)-5-(3-hydroxy-4-methoxyphenyl)-6-ethyl-3,6-dihydro-1,3,4-thiadiazin-2-one;

[1154] 3-(4-(oxazole-5-carbonylamino)benzyl)-5-(4-methylsulfonylphenyl)-6-ethyl-3,6-dihydro-1,3,4-thiadiazin-2-one;

[1155] 3-(4-(oxazole-5-carbonylamino)benzyl)-5-(4-methyleneoxyphenyl)-6-ethyl-3,6-dihydro-1,3,4-thiadiazin-2-one;

[1156] 3-(4-(oxazole-5-carbonylamino)benzyl)-5-(3-cyclopentyloxy-4-methoxyphenyl)-6-ethyl-3,6-dihydro-1,3,4-thiadiazin-2-one;

[1157] 3-(3-(oxazole-5-carbonylamino)benzyl)-5-(3-cyclopentyloxy-4-methoxyphenyl)-6-ethyl-3,6-dihydro-1,3,4-thiadiazin-2-one;

[1158] 3-(4-(oxazole-5-carbonylamino)phenethyl)-5-(3,4-dimethoxyphenyl)-3,6-dihydro-1,3,4-thiadiazin-2-one;

[1159] 3-(4-(oxazole-5-carbonylamino)phenethyl)-5-(3,4-dimethoxyphenyl)-6-ethyl-3,6-dihydro-1,3,4-thiadiazin-2-one;

[1160] 3-(4-(oxazole-5-carbonylamino)benzyl)-5-(3,4-dimethoxyphenyl)-3,6-dihydro-1,3,4-oxadiazin-2-one;

[1161] 3-(3-(oxazole-5-carbonylamino)-benzyl)-5-(3,4-dimethoxyphenyl)-3,5-dihydro-1,3,4-oxadiazin-2-one;

[1162] 3-(2-(oxazole-5-carbonylamino)benzyl)-5-(3,4-dimethoxyphenyl)-3,6-dihydro-1,3,4-oxadiazin-2-one;

[1163] 3-(4-(oxazole-5-carbonylamino)benzyl)-5-(3,4-dimethoxyphenyl)-6-ethyl-3,5-dihydro-1,3,4-oxadiazin-2-one;

[1164] 3-(3-(oxazole-5-carbonylamino)benzyl)-5-(3,4-dimethoxyphenyl)-6-ethyl-3,6-dihydro-1,3,4-oxadiazin-2-one;

[1165] 3-(2-(oxazole-5-carbonylamino)benzyl)-5-(3,4-dimethoxyphenyl)-6-ethyl-3,6-dihydro-1,3,4-oxadiazin-2-one;

[1166] 3-(4-(oxazole-5-carbonylamino)benzyl)-5-(3-methoxy-4-trifluoromethoxyphenyl)-6-ethyl-3,6-dihydro-1,3,4-oxadiazin-2-one;

[1167] 3-(4-(oxazole-5-carbonylamino)benzyl)-5-(3-methoxy-4-difluoromethoxyphenyl)-6-ethyl-3,6-dihydro-1,3,4-oxadiazin-2-one;

[1168] 3-(4-(oxazole-5-carbonylamino)benzyl)-5-(3-methoxy-4-fluoromethoxyphenyl)-6-ethyl-3,6-dihydro-1,3,4-oxadiazin-2-one;

[1169] 3-(4-(oxazole-5-carbonylamino)benzyl)-5-(3-difluoromethoxy-4-methoxyphenyl)-6-ethyl-3,6-dihydro-1,3,4-oxadiazin-2-one;

[1170] 3-(4-(oxazole-5-carbonylamino)benzyl)-5-(3-trifluoromethoxy-4-methoxyphenyl)-6-ethyl-3,6-dihydro-1,3,4-oxadiazin-2-one;

[1171] 3-(4-(oxazole-5-carbonylamino)benzyl)-5-(3-fluoromethoxy-4-methoxyphenyl)-6-ethyl-3,6-dihydro-1,3,4-oxadiazin-2-one;

[1172] 3-(4-(oxazole-5-carbonylamino)benzyl)-5-(3-methoxy-4-ethoxyphenyl)-6-ethyl-3,6-dihydro-1,3,4-oxadiazin-2-one;

[1173] 3-(4-(oxazole-5-carbonylamino)benzyl)-5-(3-ethoxy-4-methoxyphenyl)-6-ethyl-3,6-dihydro-1,3,4-oxadiazin-2-one;

[1174] 3-(4-(oxazole-5-carbonylamino)benzyl)-5-(3-hydroxy-4-methoxyphenyl)-6-ethyl-3,6-dihydro-1,3,4-oxadiazin-2-one;

[1175] 3-(4-(oxazole-5-carbonylamino)benzyl)-5-(4-methylsulfonylphenyl)-6-ethyl-3,6-dihydro-1,3,4-oxadiazin-2-one;

[1176] 3-(4-(oxazole-5-carbonylamino)benzyl)-5-(4-methyleneoxyphenyl)-6-ethyl-3,6-dihydro-1,3,4-oxadiazin-2-one;

[1177] 3-(4-(oxazole-5-carbonylamino)benzyl)-5-(3-cyclopentyloxy-4-methoxyphenyl)-6-ethyl-3,6-dihydro-1,3,4-oxadiazin-2-one;

[1178] 3-(3-(oxazole-5-carbonylamino)benzyl)-5-(3-cyclopentyloxy-4-methoxyphenyl)-6-ethyl-3,6-dihydro-1,3,4-oxadiazin-2-one;

[1179] 3-(4-(oxazole-5-carbonylamino)phenethyl)-5-(3,4-dimethoxyphenyl)-3,6-dihydro-1,3,4-oxadiazin-2-one;

[1180] 3-(4-(oxazole-5-carbonylamino)phenethyl)-5-(3,4-dimethoxyphenyl)-6-ethyl-3,6-dihydro-1,3,4-oxadiazin-2-one;

[1181] 2-(4-(pyrimidine-2-carbonylamino)benzyl)-6-(3,4-dimethoxyphenyl)-2,3,4,5-tetrahydropyridazin-3-one;

[1182] 2-(3-(pyrimidine-2-carbonylamino)benzyl)-6-(3,4-dimethoxyphenyl)-2,3,4,5-tetrahydropyridazin-3-one;

[1183] 2-(2-(pyrimidine-2-carbonylamino)benzyl)-6-(3,4-dimethoxyphenyl)-2,3,4,5-tetrahydropyridazin-3-one;

[1184] 2-(4-(pyrimidine-2-carbonylamino)benzyl)-6-(3,4-dimethoxyphenyl)-5-ethyl-2,3,4,5-tetrahydropyridazin-3-one;

[1185] 2-(3-(pyrimidine-2-carbonylamino)benzyl)-6-(3,4-dimethoxyphenyl)-5-ethyl-2,3,4,5-tetrahydropyridazin-3-one;

[1186] 2-(2-(pyrimidine-2-carbonylamino)benzyl)-6-(3,4,-dimethoxyphenyl)-5-ethyl-2,3,4,5-tetrahydropyridazin-3-one;

[1187] 2-(4-(pyrimidine-2-carbonylamino)benzyl)-6-(3-methoxy-4-trifluoromethoxyphenyl)-5-ethyl-2,3,4,5-tetrahydropyridazin-3-one;

[1188] 2-(4-(pyrimidine-2-carbonylamino)benzyl)-6-(3-methoxy-4-difluoromethoxyphenyl)-5-ethyl-2,3,4,5-tetrahydropyridazin-3-one;

[1189] 2-(4-(pyrimidine-2-carbonylamino)benzyl)-6-(3-methoxy-4-fluoromethoxyphenyl)-5-ethyl-2,3,4,5-tetrahydropyridazin-3-one;

[1190] 2-(4-(pyrimidine-2-carbonylamino)benzyl)-6-(3-difluoromethoxy-4-methoxyphenyl)-5-ethyl-2,3,4,5-tetrahydropyridazin-3-one;

[1191] 2-(4-(pyrimidine-2-carbonylamino)benzyl)-6-(3-trifluoromethoxy-4-methoxyphenyl)-5-ethyl-2,3,4,5-tetrahydropyridazin-3-one;

[1192] 2-(4-(pyrimidine-2-carbonylamino)benzyl)-6-(3-fluoromethoxy-4-methoxyphenyl)-5-ethyl-2,3,4,5-tetrahydropyridazin-3-one;

[1193] 2-(4-(pyrimidine-2-carbonylamino)benzyl)-6-(3-methoxy-4-ethoxyphenyl)-5-ethyl-2,3,4,5-tetrahydropyridazin-3-one;

[1194] 2-(4-(pyrimidine-2-carbonylamino)benzyl)-6-(3-ethoxy-4-methoxyphenyl)-5-ethyl-2,3,4,5-tetrahydropyridazin-3-one;

[1195] 2-(4-(pyrimidine-2-carbonylamino)benzyl)-6-(3-hydroxy-4-methoxyphenyl)-5-ethyl-2,3,4,5-tetrahydropyridazin-3-one;

[1196] 2-(4-(pyrimidine-2-carbonylamino)benzyl)-6-(4-methylsulfonylphenyl)-5-ethyl-2,3,4,5-tetrahydropyridazin-3-one;

[1197] 2-(4-(pyrimidine-2-carbonylamino)benzyl)-6-(4-methyleneoxyphenyl)-5-ethyl-2,3,4,5-tetrahydropyridazin-3-one;

[1198] 2-(4-(pyrimidine-2-carbonylamino)benzyl)-6-(3-cyclopentyloxy-4-methoxyphenyl)-5-ethyl-2,3,4,5-tetrahydropyridazin-3-one;

[1199] 2-(3-(pyrimidine-2-carbonylamino)benzyl)-6-(3-cyclopentyloxy-4-methoxyphenyl)-5-ethyl-2,3,4,5-tetrahydropyridazin-3-one;

[1200] 2-(4-(pyrimidine-2-carbonylamino)phenethyl)-6-(3,4-dimethoxyphenyl)-2,3,4,5-tetrahydropyridazin-3-one;

[1201] 2-(4-(pyrimidine-2-carbonylamino)phenethyl)-6-(3,4-dimethoxyphenyl)-5-ethyl-2,3,4,5-tetrahydropyridazin-3-one;

[1202] 3-(4-(pyrimidine-2-carbonylamino)benzyl)-5-(3,4-dimethoxyphenyl)-3,6-dihydro-1,3,4-thiadiazin-2-one;

[1203] 3-(3-(pyrimidine-2-carbonylamino)benzyl)-5-(3,4-dimethoxyphenyl)-3,6-dihydro-1,3,4-thiadiazin-2-one;

[1204] 3-(2-(pyrimidine-2-carbonylamino)benzyl)-5-(3,4-dimethoxyphenyl)-3,6-dihydro-1,3,4-thiadiazin-2-one;

[1205] 3-(4-(pyrimidine-2-carbonylamino)benzyl)-5-(3,4-dimethoxyphenyl)-6-ethyl-3,6-dihydro-1,3,4-thiadiazin-2-one;

[1206] 3-(3-(pyrimidine-2-carbonylamino)benzyl)-5-(3,4-dimethoxyphenyl)-6-ethyl-3,6-dihydro-1,3,4-thiadiazin-2-one;

[1207] 3-(2-(pyrimidine-2-carbonylamino)benzyl)-5-(3,4-dimethoxyphenyl)-6-ethyl-3,6-dihydro-1,3,4-thiadiazin-2-one;

[1208] 3-(4-(pyrimidine-2-carbonylamino)benzyl)-5-(3-methoxy-4-trifluoromethoxyphenyl)-6-ethyl-3,6-dihydro-1,3,4-thiadiazin-2-one;

[1209] 3-(4-(pyrimidine-2-carbonylamino)benzyl)-5-(3-methoxy-4-difluoromethoxyphenyl)-6-ethyl-3,6-dihydro-1,3,4-thiadiazin-2-one;

[1210] 3-(4-(pyrimidine-2-carbonylamino)benzyl)-5-(3-methoxy-4-fluoromethoxyphenyl)-6-ethyl-3,6-dihydro-1,3,4,-thiadiazin-2-one;

[1211] 3-(4-(pyrimidine-2-carbonylamino)benzyl)-5-(3-difluoromethoxy-4-methoxyphenyl)-6-ethyl-3,6-dihydro-1,3,4-thiadiazin-2-one;

[1212] 3-(4-(pyrimidine-2-carbonylamino)benzyl)-5-(3-trifluoromethoxy-4-methoxyphenyl)-6-ethyl-3,6-dihydro-1,3,4-thiadiazin-2-one;

[1213] 3-(4-(pyrimidine-2-carbonylamino)benzyl)-5-(3-fluoromethoxy-4-methoxyphenyl)-6-ethyl-3,6-dihydro-1,3,4-thiadiazin-2-one;

[1214] 3-(4-(pyrimidine-2-carbonylamino)benzyl)-5-(3-methoxy-4-ethoxyphenyl)-6-ethyl-3,6-dihydro-1,3,4-thiadiazin-2-one;

[1215] 3-(4-(pyrimidine-2-carbonylamino)benzyl)-5-(3-ethoxy-4-methoxyphenyl)-6-ethyl-3,6-dihydro-1,3,4-thiadiazin-2-one;

[1216] 3-(4-(pyrimidine-2-carbonylamino)benzyl)-5-(3-hydroxy-4-methoxyphenyl)-6-ethyl-3,6-dihydro-1,3,4-thiadiazin-2-one;

[1217] 3-(4-(pyrimidine-2-carbonylamino)benzyl)-5-(4-methylsulfonylphenyl)-6-ethyl-3,6-dihydro-1,3,4-thiadiazin-2-one;

[1218] 3-(4-(pyrimidine-2-carbonylamino)benzyl)-5-(4-methyleneoxyphenyl)-6-ethyl-3,6-dihydro-1,3,4-thiadiazin-2-one;

[1219] 3-(4-(pyrimidine-2-carbonylamino)benzyl)-5-(3-cyclopentyloxy-4-methoxyphenyl)-6-ethyl-3,6-dihydro-1,3,4-thiadiazin-2-one;

[1220] 3-(3-(pyrimidine-2-carbonylamino)benzyl)-5-(3-cyclopentyloxy-4-methoxyphenyl)-6-ethyl-3,6-dihydro-1,3,4-thiadiazin-2-one;

[1221] 3-(4-(pyrimidine-2-carbonylamino)phenethyl)-5-(3,4-dimethoxyphenyl)-3,6-dihydro-1,3,4-thiadiazin-2-one;

[1222] 3-(4-(pyrimidine-2-carbonylamino)phenethyl)-5-(3,4-dimethoxyphenyl)-6-ethyl-3,6-dihydro-1,3,4-thiadiazin-2-one;

[1223] 3-(4-(pyrimidine-2-carbonylamino)benzyl)-5-(3,4-dimethoxyphenyl)-3,6-dihydro-1,3,4-oxadiazin-2-one;

[1224] 3-(3-(pyrimidine-2-carbonylamino)benzyl)-5-(3,4-dimethoxyphenyl)-3,6-dihydro-1,3,4-oxadiazin-2-one;

[1225] 3-(3-(pyrimidine-2-carbonylamino)benzyl)-5-(3,4-dimethoxyphenyl)-3,6-dihydro-1,3,4-oxadiazin-2-one;

[1226] 3-(4-(pyrimidine-2-carbonylamino)benzyl)-5-(3,4-dimethoxyphenyl)-6-ethyl-3,6-dihydro-1,3,4-oxadiazin-2-one;

[1227] 3-(3-(pyrimidine-2-carbonylamino)benzyl)-5-(3,4-dimethoxyphenyl)-6-ethyl-3,6-dihydro-1,3,4-oxadiazin-2-one;

[1228] 3-(2-(pyrimidine-2-carbonylamino)benzyl)-5-(3,4-dimethoxyphenyl)-6-ethyl-3,6-dihydro-1,3,4-oxadiazin-2-one;

[1229] 3-(4-(pyrimidine-2-carbonylamino)benzyl)-5-(3-methoxy-4-trifluoromethoxyphenyl)-6-ethyl-3,6-dihydro-1,3,4-oxadiazin-2-one;

[1230] 3-(4-(pyrimidine-2-carbonylamino)benzyl)-5-(3-methoxy-4-difluoromethoxyphenyl)-6-ethyl-3,6-dihydro-1,3,4-oxadiazin-2-one;

[1231] 3-(4-(pyrimidine-2-carbonylamino)benzyl)-5-(3-methoxy-4-fluoromethoxyphenyl)-6-ethyl-3,6-dihydro-1,3,4-oxadiazin-2-one;

[1232] 3-(4-(pyrimidine-2-carbonylamino)benzyl)-5-(3-difluoromethoxy-4-methoxyphenyl)-6-ethyl-3,6-dihydro-1,3,4-oxadiazin-2-one;

[1233] 3-(4-(pyrimidine-2-carbonylamino)benzyl)-5-(3-trifluoromethoxy-4-methoxyphenyl)-6-ethyl-3,6-dihydro-1,3,4-oxadiazin-2-one;

[1234] 3-(4-(pyrimidine-2-carbonylamino)benzyl)-5-(3-fluoromethoxy-4-methoxyphenyl)-6-ethyl-3,6-dihydro-1,3,4-oxadiazin-2-one;

[1235] 3-(4-(pyrimidine-2-carbonylamino)benzyl)-5-(3-methoxy-4-ethoxyphenyl)-6-ethyl-3,6-dihydro-1,3,4-oxadiazin-2-one;

[1236] 3-(4-(pyrimidine-2-carbonylamino)benzyl)-5-(3-ethoxy-4-methoxyphenyl)-6-ethyl-3,6-dihydro-1,3,4-oxadiazin-2-one;

[1237] 3-(4-(pyrimidine-2-carbonylamino)benzyl)-5-(3-hydroxy-4-methoxyphenyl)-6-ethyl-3,6-dihydro-1,3,4-oxadiazin-2-one;

[1238] 3-(4-(pyrimidine-2-carbonylamino)benzyl)-5-(4-methylsulfonylphenyl)-6-ethyl-3,6-dihydro-1,3,4-oxadiazin-2-one;

[1239] 3-(4-(pyrimidine-2-carbonylamino)benzyl)-5-(4-methyleneoxyphenyl)-6-ethyl-3,6-dihydro-1,3,4-oxadiazin-2-one;

[1240] 3-(4-(pyrimidine-2-carbonylamino)benzyl)-5-(3-cyclopentyloxy-4-methoxyphenyl)-6-ethyl-3,6-dihydro-1,3,4-oxadiazin-2-one;

[1241] 3-(3-(pyrimidine-2-carbonylamino)benzyl)-5-(3-cyclopentyloxy-4-methoxyphenyl)-6-ethyl-3,6-dihydro-1,3,4-oxadiazin-2-one;

[1242] 3-(4-(pyrimidine-2-carbonylamino)phenethyl)-5-(3,4-dimethoxyphenyl)-3,6-dihydro-1,3,4-oxadiazin-2-one;

[1243] 3-(4-(pyrimidine-2-carbonylamino)phenethyl)-5-(3,4-dimethoxyphenyl)-6-ethyl-3,6-dihydro-1,3,4-oxadiazin-2-one;

[1244] 2-(4-(pyrazole-3-carbonylamino)benzyl)-6-(3,4-dimethoxyphenyl)-2,3,4,5-tetrahydropyridazin-3-one;

[1245] 2-(3-(pyrazole-3-carbonylamino)benzyl)-6-(3,4-dimethoxyphenyl)-2,3,4,5-tetrahydropyridazin-3-one;

[1246] 2-(2-(pyrazole-3-carbonylamino)benzyl)-6-(3,4-dimethoxyphenyl)-2,3,4,5-tetrahydropyridazin-3-one;

[1247] 2-(4-(pyrazole-3-carbonylamino)benzyl)-6-(3,4-dimethoxyphenyl)-5-ethyl-2,3,4,5-tetrahydropyridazin-3-one;

[1248] 2-(3-(pyrazole-3-carbonylamino)benzyl)-6-(3,4-dimethoxyphenyl)-5-ethyl-2,3,4,5-tetrahydropyridazin-3-one;

[1249] 2-(2-(pyrazole-3-carbonylamino)benzyl)-6-(3,4-dimethoxyphenyl)-5-ethyl-2,3,4,5-tetrahydropyridazin-3-one;

[1250] 2-(4-(pyrazole-3-carbonylamino)benzyl)-6-(3-methoxy-4-trifluoromethoxyphenyl)-5-ethyl-2,3,4,5-tetrahydropyridazin-3-one;

[1251] 2-(4-(pyrazole-3-carbonylamino)benzyl)-6-(3-methoxy-4-difluoromethoxyphenyl)-5-ethyl-2,3,4,5-tetrahydropyridazin-3-one;

[1252] 2-(4-(pyrazole-3-carbonylamino)benzyl)-6-(3-methoxy-4-fluoromethoxyphenyl)-5-ethyl-2,3,4,5-tetrahydropyridazin-3-one;

[1253] 2-(4-(pyrazole-3-carbonylamino)benzyl)-6-(3-difluoromethoxy-4-methoxyphenyl)-5-ethyl-2,3,4,5-tetrahydropyridazin-3-one;

[1254] 2-(4-(pyrazole-3-carbonylamino)benzyl)-6-(3-trifluoromethoxy-4-methoxyphenyl)-5-ethyl-2,3,4,5-tetrahydropyridazin-3-one;

[1255] 2-(4-(pyrazole-3-carbonylamino)benzyl)-6-(3-fluoromethoxy-4-methoxyphenyl)-5-ethyl-2,3,4,5-tetrahydropyridazin-3-one;

[1256] 2-(4-(pyrazole-3-carbonylamino)benzyl)-6-(3-methoxy-4-ethoxyphenyl)-5-ethyl-2,3,4,5-tetrahydropyridazin-3-one;

[1257] 2-(4-(pyrazole-3-carbonylamino)benzyl)-6-(3-ethoxy-4-methoxyphenyl)-5-ethyl-2,3,4,5-tetrahydropyridazin-3-one;

[1258] 2-(4-(pyrazole-3-carbonylamino)benzyl)-6-(3-hydroxy-4-methoxyphenyl)-5-ethyl-2,3,4,5-tetrahydropyridazin-3-one;

[1259] 2-(4-(pyrazole-3-carbonylamino)benzyl)-6-(4-methylsulfonylphenyl)-5-ethyl-2,3,4,5-tetrahydropyridazin-3-one;

[1260] 2-(4-(pyrazole-3-carbonylamino)benzyl)-6-(4-methylenoxyphenyl)-5-ethyl-2,3,4,5-tetrahydropyridazin-3-one;

[1261] 2-(4-(pyrazole-3-carbonylamino)benzyl)-6-(3-cyclopentyloxy-4-methoxyphenyl)-5-ethyl-2,3,4,5-tetrahydropyridazin-3-one;

[1262] 2-(3-(pyrazole-3-carbonylamino)benzyl)-6-(3-cyclopentyloxy-4-methoxyphenyl)-5-ethyl-2,3,4,5-tetrahydropyridazin-3-one;

[1263] 2-(4-(pyrazole-3-carbonylamino)phenethyl)-6-(3,4-dimethoxyphenyl)-2,3,4,5-tetrahydropyridazin-3-one;

[1264] 2-(4-(pyrazole-3-carbonylamino)phenethyl)-6-(3,4-dimethoxyphenyl)-5-ethyl-2,3,4,5-tetrahydropyridazin-3-one;

[1265] 3-(4-(pyrazole-3-carbonylamino)benzyl)-5-(3,4-dimethoxyphenyl)-3,6-dihydro-1,3,4-thiadiazin-2-one;

[1266] 3-(3-(pyrazole-3-carbonylamino)benzyl)-5-(3,4-dimethoxyphenyl)-3,6-dihydro-1,3,4-thiadiazin-2-one;

[1267] 3-(2-(pyrazole-3-carbonylamino)benzyl)-5-(3,4-dimethoxyphenyl)-3,6-dihydro-1,3,4-thiadiazin-2-one;

[1268] 3-(4-(pyrazole-3-carbonylamino)benzyl)-5-(3,4-dimethoxyphenyl)-6-ethyl-3,6-dihydro-1,3,4-thiadiazin-2-one;

[1269] 3-(3-(pyrazole-3-carbonylamino)benzyl)-5-(3,4-dimethoxyphenyl)-6-ethyl-3,6-dihydro-1,3,4-thiadiazin-2-one;

[1270] 3-(2-(pyrazole-3-carbonylamino)benzyl)-5-(3,4-dimethoxyphenyl)-6-ethyl-3,6-dihydro-1,3,4-thiadiazin-2-one;

[1271] 3-(4-(pyrazole-3-carbonylamino)benzyl)-5-(3-methoxy-4-trifluoromethoxyphenyl)-6-ethyl-3,6-dihydro-1,3,4-thiadiazin-2-one;

[1272] 3-(4-(pyrazole-3-carbonylamino)benzyl)-5-(3-methoxy-4-difluoromethoxyphenyl)-6-ethyl-3,6-dihydro-1,3,4-thiadiazin-2-one;

[1273] 3-(4-(pyrazole-3-carbonylamino)benzyl)-5-(3-methoxy-4-fluoromethoxyphenyl)-6-ethyl-3,6-dihydro-1,3,4-thiadiazin-2-one;

[1274] 3-(4-(pyrazole-3-carbonylamino)benzyl)-5-(3-difluoromethoxy-4-methoxyphenyl)-6-ethyl-3,6-dihydro-1,3,4-thiadiazin-2-one;

[1275] 3-(4-(pyrazole-3-carbonylamino)benzyl)-5-(3-trifluoromethoxy-4-methoxyphenyl)-6-ethyl-3,6-dihydro-1,3,4-thiadiazin-2-one;

[1276] 3-(4-(pyrazole-3-carbonylamino)benzyl)-5-(3-fluoromethoxy-4-methoxyphenyl)-6-ethyl-3,6-dihydro-1,3,4-thiadiazin-2-one;

[1277] 3-(4-(pyrazole-3-carbonylamino)benzyl)-5-(3-methoxy-4-ethoxyphenyl)-5-ethyl-3,6-dihydro-1,3,4-thiadiazin-2-one;

[1278] 3-(4-(pyrazole-3-carbonylamino)benzyl)-5-(3-ethoxy-4-methoxyphenyl)-6-ethyl-3,6-dihydro-1,3,4-thiadiazin-2-one;

[1279] 3-(4-(pyrazole-3-carbonylamino)benzyl)-5-(3-hydroxy-4-methoxyphenyl)-6-ethyl-3,6-dihydro-1,3,4-thiadiazin-2-one;

[1280] 3-(4-(pyrazole-3-carbonylamino)benzyl)-5-(4-methylsulfonylphenyl)-6-ethyl-3,6-dihydro-1,3,4-thiadiazin-2-one;

[1281] 3-(4-(pyrazole-3-carbonylamino)benzyl)-5-(4-methyleneoxyphenyl)-6-ethyl-3,6-dihydro-1,3,4-thiadiazin-2-one;

[1282] 3-(4-(pyrazole-3-carbonylamino)benzyl)-5-(3-cyclopentyloxy-4-methoxyphenyl)-6-ethyl-3,6-dihydro-1,3,4-thiadiazin-2-one;

[1283] 3-(3-(pyrazole-3-carbonylamino)benzyl)-5-(3-cyclopentyloxy-4-methoxyphenyl)-6-ethyl-3,6-dihydro-1,3,4-thiadiazin-2-one;

[1284] 3-(4-(pyrazole-3-carbonylamino)phenethyl)-5-(3,4-dimethoxyphenyl)-3,6-dihydro-1,3,4-thiadiazin-2-one;

[1285] 3-(4-(pyrazole-3-carbonylamino)phenethyl)-5-(3,4-dimethoxyphenyl)-6-ethyl-3,6-dihydro-1,3,4-thiadiazin-2-one;

[1286] 3-(4-(pyrazole-3-carbonylamino)benzyl)-5-(3,4-dimethoxyphenyl)-3,6-dihydro-1,3,4-oxadiazin-2-one;

[1287] 3-(3-(pyrazole-3-carbonylamino)benzyl)-5-(3,4-dimethoxyphenyl)-3,6-dihydro-1,3,4-oxadiazin-2-one;

[1288] 3-(2-(pyrazole-3-carbonylamino)benzyl)-5-(3,4-dimethoxyphenyl)-3,6-dihydro-1,3,4-oxadiazin-2-one;

[1289] 3-(4-(pyrazole-3-carbonylamino)benzyl)-5-(3,4-dimethoxyphenyl)-6-ethyl-3,6-dihydro-1,3,4-oxadiazin-2-one;

[1290] 3-(3-(pyrazole-3-carbonylamino)benzyl)-5-(3,4-dimethoxyphenyl)-6-ethyl-3,6-dihydro-1,3,4-oxadiazin-2-one;

[1291] 3-(2-(pyrazole-3-carbonylamino)benzyl)-5-(3,4-dimethoxyphenyl)-6-ethyl-3,6-dihydro-1,3,4-oxadiazin-2-one;

[1292] 3-(4-(pyrazole-3-carbonylamino)benzyl)-5-(3-methoxy-4-trifluoromethoxyphenyl)-6-ethyl-3,6-dihydro-1,3,4-oxadiazin-2-one;

[1293] 3-(4-(pyrazole-3-carbonylamino)benzyl)-5-(3-methoxy-4-difluoromethoxyphenyl)-6-ethyl-3,5-dihydro-1,3,4-oxadiazin-2-one;

[1294] 3-(4-(pyrazole-3-carbonylamino)benzyl)-5-(3-methoxy-4-fluoromethoxyphenyl)-6-ethyl-3,6-dihydro-1,3,4-oxadiazin-2-one;

[1295] 3-(4-(pyrazole-3-carbonylamino)benzyl)-5-(3-difluoromethoxy-4-methoxyphenyl)-6-ethyl-3,6-dihydro-1,3,4-oxadiazin-2-one;

[1296] 3-(4-(pyrazole-3-carbonylamino)benzyl)-5-(3-trifluoromethoxy-4-methoxyphenyl)-6-ethyl-3,6-dihydro-1,3,4-oxadiazin-2-one;

[1297] 3-(4-(pyrazole-3-carbonylamino)benzyl)-5-(3-fluoromethoxy-4-methoxyphenyl)-6-ethyl-3,6-dihydro-1,3,4-oxadiazin-2-one;

[1298] 3-(4-(pyrazole-3-carbonylamino)benzyl)-5-(3-methoxy-4-ethoxyphenyl)-6-ethyl-3,6-dihydro-1,3,4-oxadiazin-2-one;

[1299] 3-(4-(pyrazole-3-carbonylamino)benzyl)-5-(3-ethoxy-4-methoxyphenyl)-6-ethyl-3,6-dihydro-1,3,4-oxadiazin-2-one;

[1300] 3-(4-(pyrazole-3-carbonylamino)benzyl)-5-(3-hydroxy-4-methoxyphenyl)-6-ethyl-3,6-dihydro-1,3,4-oxadiazin-2-one;

[1301] 3-(4-(pyrazole-3-carbonylamino)benzyl)-5-(4-methylsulfonylphenyl)-6-ethyl-3,6-dihydro-1,3,4-oxadiazin-2-one;

[1302] 3-(4-(pyrazole-3-carbonylamino)benzyl)-5-(4-methyleneoxyphenyl)-6-ethyl-3,6-dihydro-1,3,4-oxadiazin-2-one;

[1303] 3-(4-(pyrazole-3-carbonylamino)benzyl)-5-(3-cyclopentyloxy-4-methoxyphenyl)-6-ethyl-3,6-dihydro-1,3,4-oxadiazin-2-one;

[1304] 3-(3-(pyrazole-3-carbonylamino)benzyl)-5-(3-cyclopentyloxy-4-methoxyphenyl)-6-ethyl-3,6-dihydro-1,3,4-oxadiazin-2-one;

[1305] 3-(4-(pyrazole-3-carbonylamino)phenethyl)-5-(3,4-dimethoxyphenyl)-3,6-dihydro-1,3,4-oxadiazin-2-one;

[1306] 3-(4-(pyrazole-3-carbonylamino)phenethyl)-5-(3,4-dimethoxyphenyl)-6-ethyl-3,6-dihydro-1,3,4-oxadiazin-2-one;

[1307] 2-(3-nicotinoylaminobenzyl)-6-(3-ethoxy-4-methoxyphenyl)-2,3,4,5-tetrahydropyridazin-3-one, m.p. 204°;

[1308] 2-(4-isoncotinoylaminobenzyl)-6-(3-ethoxy-4-methoxyphenyl)-2,3,4,5-tetrahydropyridazin-3-one, hydrochloride m.p. 252°;

[1309] 2-(4-pyrazinecarbonylaminobenzyl)-6-(3-ethoxy-4-methoxyphenyl)-2,3,4,5-tetrahydropyridazin-3-one, m.p. 202°;

[1310] 2-(4-(isoxazole-5-carbonylamino)benzyl)-6-(3-ethoxy-4-methoxyphenyl)-2,3,4,5-tetrahydropyridazin-3-one, m.p. 192°;

[1311] 2-(4-nicotinoylaminobenzyl)-6-(3-cyclopentyloxy-4-methoxyphenyl)-2,3,4,5-tetrahydropyridazin-3-one, m.p. 205°

[1312] 2-(4-nicotinoylaminobenzyl)-6-(3,4-dimethoxyphenyl)-2,3,4,5-tetrahydropyridazin-3-one, hydrochloride m.p. 212°;

[1313] d) compounds, disclosed in EP 0 539 806 b1, selected from the group consisting of

[1314] 5-(3-methoxy-4-difluoromethoxyphenyl)-6-ethyl-3,6-dihydro-1,3,4-thiadiazin-2-one, m.p. 97°;

[1315] 5-(3-methoxy-4-trifluoromethoxyphenyl)-6-ethyl-3,6-dihydro-1,3,4-thiadiazin-2-one;

[1316] 5-(3-methoxy-4-trifluoromethoxyphenyl)-6-methyl-3,6-dihydro-1,3,4-thiadiazin-2-one;

[1317] 5-(3-methoxy-4-difluoromethoxyphenyl)-6-methyl-3,6-dihydro-1,3,4-thiadiazin-2-one;

[1318] 5-[3-methoxy-4-(1,1,2,2-tetrafluoroethoxy)phenyl]-6-ethyl-3,6-dihydro-1,3,4-thiadiazin-2-one;

[1319] 5-(3-methoxy-4-chloromethoxyphenyl)-6-ethyl-3,6-dihydro-1,3,4-thiadiazin-2-one;

[1320] 5-(3-methoxy-4-chloromethoxyphenyl)-6-methyl-3,6-dihydro-1,3,4-thiadiazin-2-one;

[1321] 5-(3-methoxy-4-pentachloroethoxyphenyl)-6-ethyl-3,6-dihydro-1,3,4-thiadiazin-2-one;

[1322] 5-(3-methoxy-4-trifluoromethoxyphenyl)-6-propyl-3,6-dihydro-1,3,4-thiadiazin-2-one;

[1323] 5-(3-methoxy-4-difluoromethoxyphenyl)-6-propyl-3,6-dihydro-1,3,4-thiadiazin-2-one;

[1324] 5-[3-methoxy-4-(1,1,2,-trifluoroethoxy)phenyl]-6-ethyl-3,6-dihydro-1,3,4-thiadiazin-2-one;

[1325] 5-[3-methoxy-4-(1,1,2,-trifluoroethoxy)phenyl]-6-methyl-3,6-dihydro-1,3,4-thiadiazin-2-one;

[1326] 5-(3-methoxy-4-difluoromethoxyphenyl)-3,6-dihydro-1,3,4-thiadiazin-2-one, m.p. 120°;

[1327] 5-(3-methoxy-4-trifluoromethoxyphenyl)-3,6-dihydro-1,3,4-thiadiazin-2-one;

[1328] 5-(4-trifluoromethoxyphenyl)-3,6-dihydro-1,3,4-thiadiazin-2-one;

[1329] 5-[3-methoxy-4-(1,1,2,2-tetrafluoroethoxy)phenyl]-3,6-dihydro-1,3,4-thiadiazin-2-one;

[1330] 5-(3-methoxy-4-chloromethoxyphenyl)-3,6-dihydro-1,3,4-thiadiazin-2-one;

[1331] 5-(3-methoxy-4-dichloromethoxyphenyl)-3,6-dihydro-1,3,4-thiadiazin-2-one;

[1332] 5-(3-methoxy-4-pentachloroethoxyphenyl)-3,6-dihydro-1,3,4-thiadiazin-2-one;

[1333] 5-(4-difluoromethoxyphenyl)-3,6-dihydro-1,3,4-thiadiazin-2-one;

[1334] 5-[3-methoxy-4-(1,1,2,2,3-pentafluoropropoxy)phenyl]-6-ethyl-3,6-dihydro-1,3,4-thiadiazin-2-one;

[1335] 5-[bis-3,4-(difluoromethoxy)phenyl]-3,6-dihydro-1,3,4-thiadiazin-2-one;

[1336] 5-[bis-3,4-(dichloromethoxy)phenyl]-3,6-dihydro-1,3,4-thiadiazin-2-one;

[1337] 5-[bis-3,4-(1,2-difluoroethoxy)phenyl]-3,6-dihydro-1,3,4-thiadiazin-2-one;

[1338] 5-[3-ethoxy-4-(1,1,2,2,-tetrafluoroethoxy)phenyl]-3,6-dihydro-1,3,4-thiadiazin-2-one;

[1339] 5-[3-methoxy-4-(1,2,2,-trichloroethoxy)phenyl]-3,6-dihydro-1,3,4-thiadiazin-2-one;

[1340] 5-[4-(2,2,2-trifluoroethoxy)phenyl]-6-ethyl-3,6-dihydro-1,3,4-thiadiazin-2-one, m.p. 102°;

[1341] 5-[3-methoxy-4-(2,2,2-trifluoroethoxy)phenyl]-6-ethyl-3,6-dihydro-1,3,4-thiadiazin-2-one, m.p. 123-125°;

[1342] 5-[3-methoxy-4-(2,2,2-trifluoroethoxy)phenyl]-3,6-dihydro-1,3,4-thiadiazin-2-one, m.p. 120°;

[1343] 5-[3-(2,2,2-trifluoroethoxy)-4-methoxyphenyl]-6-ethyl-3,6-dihydro-1,3,4-thiadiazin-2-one, m.p. 120-121°;

[1344] 5-(3-difluoromethoxy-4-methoxyphenyl)-6-ethyl-3,6-dihydro-1,3,4-thiadiazin-2-one, m.p. 105°;

[1345] e) compounds, disclosed in EP 0 618 201 A1, selected from the group consisting of

[1346] 3-dimethylaminopropyl-5-(3,4-dimethoxyphenyl)-6-ethyl-3,6-dihydro-1,3,4-thiadiazinon-2-one, m.p. 175°;

[1347] 3-dimethylaminopropyl-5-(3-methoxy-4-trifluoromethoxyphenyl)-6-ethyl-3,6-dihydro-1,3,4-thiadiazinon-2-one;

[1348] 3-dimethylaminopropyl-5-(3-methoxy-4-difluoromethoxyphenyl)-6-ethyl-3,6-dihydro-1,3,4-thiadiazinon-2-one;

[1349] 3-dimethylaminopropyl-5-(3-methoxy-4-fluoromethoxyphenyl)-6-ethyl-3,6-dihydro-1,3,4-thiadiazinon-2-one;

[1350] 3-dimethylaminopropyl-5-(4-methoxy-3-difluoromethoxyphenyl)-6-ethyl-3,6-dihydro-1,3,4-thiadiazinon-2-one;

[1351] 3-dimethylaminopropyl-5-[4-methoxy-3-(2,2,2-trifluoroethoxy)phenyl]-6-ethyl-3,6-dihydro-1,3,4-thiadiazinon-2-one;

[1352] 3-dimethylaminopropyl-5-(4-methoxy-3-fluoromethoxyphenyl)-6-ethyl-3,6-dihydro-1,3,4-thiadiazinon-2-one;

[1353] 3-dimethylaminopropyl-5-(3-methoxy-4-ethoxyphenyl)-6-ethyl-3,6-dihydro-1,3,4-thiadiazinon-2-one;

[1354] 3-dimethylaminopropyl-5-(4-methoxy-3-ethoxyphenyl)-6-ethyl-3,6-dihydro-1,3,4-thiadiazinon-2-one;

[1355] 3-dimethylaminopropyl-5-(3-methoxy-4-hydroxyphenyl)-6-ethyl-3,6-dihydro-1,3,4-thiadiazinon-2one;

[1356] 3-dimethylaminopropyl-5-(3,4-dimethoxyphenyl)-3,6dihydro-1,3,4-thiadiazinon-2-one;

[1357] 2-dimethylaminoethyl-5-(3,4-dimethoxyphenyl)-6-ethyl-3,6-dihydro-1,3,4-thiadiazinon-2-one;

[1358] 2-dimethylaminoethyl-5-(3-methoxy-4-trifluoromethoxyphenyl)-6-ethyl-3,6-dihydro-1,3,4-thiadiazinon-2-one;

[1359] 2-dimethylaminoethyl-5-(3-methoxy-4-difluoromethoxyphenyl)-6-ethyl-3,6-dihydro-1,3,4-thiadiazinon-2-one;

[1360] 2-dimethylaminoethyl-5-(3-methoxy-4-fluoromethoxyphenyl)-6-ethyl-3,6-dihydro-1,3,4-thiadiazinon-2-one;

[1361] 2-dimethylaminoethyl-5-(4-methoxy-3-difluoromethoxyphenyl)-6-ethyl-3,6-dihydro-1,3,4-thiadiazinon-2-one;

[1362] 2-dimethylaminoethyl-5-(4-methoxy-3-fluoromethoxyphenyl)-6-ethyl-3,6-dihydro-1,3,4-thiadiazinon-2-one;

[1363] 2-dimethylaminoethyl-5-(3-methoxy-4-ethoxyphenyl)-6-ethyl-3,6-dihydro-1,3,4-thiadiazinon-2-one;

[1364] 2-dimethylaminoethyl-5-(4-methoxy-3-ethoxyphenyl)-6-ethyl-3,6-dihydro-1,3,4-thiadiazinon-2-one;

[1365] 2-dimethylaminoethyl-5-(4-methoxy-3-hydroxyphenyl)-6-ethyl-3,6-dihydro-1,3,4-thiadiazinon-2-one;

[1366] 3-morpholinopropyl-5-[3-methoxy-4-(1,1,2,2,3-pentafluoropropoxy)phenyl]-6-ethyl-3,6-dihydro-1,3,4-thiadiazinon-2-one;

[1367] 3-dimethylaminopropyl-5-[3,4,-bis-(difluoromethoxy)phenyl]-3,6-dihydro-1,3,4-thiadiazinon-2-one;

[1368] 3-dimethylaminopropyl-5-[3-methoxy-4-(1,1,2-trifluoroethoxy)phenyl]-3,6-dihydro-1,3,4-thiadiazinon-2-one;

[1369] 3-dimethylaminopropyl-5-[3,4-bis-(chloromethoxy)phenyl]-3,6-dihydro-1,3,4-thiadiazinon-2-one;

[1370] 3-morpholinopropyl-5-(3-methoxy-4-fluoromethoxyphenyl)-6-ethyl-3,6-dihydro-1,3,4-thiadiazinon-2-one;

[1371] 3-morpholinopropyl-5-(3-methoxy-4-trifluoromethoxyphenyl)-6-ethyl-3,6-dihydro-1,3,4-thiadiazinon-2-one;

[1372] 3-piperidinopropyl-5-(3-methoxy-4-difluoromethoxyphenyl)-6-ethyl-3,6-dihydro-1,3,4-thiadiazinon-2-one;

[1373] 3-morpholinopropyl-5-(3,4-dimethoxyphenyl)-6-ethyl-3,6-dihydro-1,3,4-thiadiazinon-2-one;

[1374] 3-piperidinopropyl-5-(3,4-dimethoxyphenyl))-6-ethyl-3,6-dihydro-1,3,4-thiadiazinon-2-one;

[1375] 3-pyrrolidinopropyl-5-(3,4-dimethoxyphenyl)-6-ethyl-3,6-dihydro-1,3,4-thiadiazinon-2-one;

[1376] 3-morpholinopropyl-5-(3-methoxy-4-ethoxyphenyl)-6-ethyl-3,6-dihydro-1,3,4-thiadiazinon-2-one;

[1377] 3-piperidinopropyl-5-(3-methoxy-4-ethoxyphenyl)-6-ethyl-3,6-dihydro-1,3,4-thiadiazinon-2-one;

[1378] 3-pyrrolidinopropyl-5-(3-methoxy-4-ethoxyphenyl)-6-ethyl-3,6-dihydro-1,3,4-thiadiazinon-2-one;

[1379] 3-morpholinopropyl-5-(4-methoxy-3-ethoxyphenyl)-6-ethyl-3,6-dihydro-1,3,4-thiadiazinon-2-one;

[1380] 3-piperidinopropyl-5-(4-methoxy-3-ethoxyphenyl)-6-ethyl-3,6-dihydro-1,3,4-thiadiazinon-2-one;

[1381] 3-morpholinopropyl-5-(3-methoxy-4-difluoromethoxyphenyl)-6-ethyl-3,6-dihydro-1,3,4-thiadiazinon-2-one;

[1382] 3-piperidinopropyl-5-(4-methoxy-3-difluoromethoxyphenyl)-6-ethyl-3,6-dihydro-1,3,4-thiadiazinon-2-one;

[1383] 3-piperidinopropyl-5-[3-(2,2,2-trifluoroethoxy)-4-methoxyphenyl]-6-ethyl-3,6-dihydro-1,3,4-thiadiazinon-2-one;

[1384] 3-morpholinopropyl-5-[3-(2,2,2-trifluoroethoxy)-4-methoxyphenyl]-6-ethyl-3,6-dihydro-1,3,4-thiadiazinon-2-one;

[1385] 2-morpholinoethyl-5-(3-methoxy-4-fluoromethoxyphenyl)-6-ethyl-3,6-dihydro-1,3,4-thiadiazinon-2-one;

[1386] 2-morpholinoethyl-5-(3-methoxy-4-trifluoromethoxyphenyl)-6-ethyl-3,6-dihydro-1,3,4-thiadiazinon-2-one;

[1387] f) Compounds, disclosed in DE 196 04 388 A1, selected from the group consisting of

[1388] 3-(N,N-diethylamino)propyl N-[4-(3,6-dihydro-5-(3,4-dimethoxyphenyl)-2-oxo-2H-1,3,4-thiadiazin-3-ylmethyl)phenyl]carbamate;

[1389] 2-(N,N-diethylamino)ethyl N-[4-(3,6-dihydro-5-(3,4-dimethoxyphenyl)-2-oxo-2H-1,3,4-thiadiazin-3-ylmethyl)phenyl]carbamate;

[1390] 2-(N,N-diisopropylamino)ethyl N-[4-(3,6-dihydro-5-(3,4-dimethoxyphenyl)-2-oxo-2H-1,3,4-thiadiazin-3-ylmethyl)phenyl]carbamate, hydrochloride, m.p. 218°;

[1391] 6-(N,N-dimethylamino)hexyl N-[4-(3,6-dihydro-5-(3,4-dimethoxyphenyl)-2-oxo-2H-1,3,4-thiadiazin-3-ylmethylphenyl]carbamate;

[1392] 2-(N,N-dimethylamino)-1-methylethyl N-[4-(3,6-dihydro-5-(3,4-dimethoxyphenyl)-2-oxo-2H-1,3,4-thiadiazin-3-ylmethyl)phenyl]carbamate;

[1393] 1-methyl-4-piperidyl N-[4-(3,6-dihydro-5-(3,4-dimethoxyphenyl)-2-oxo-2H-1,3,4-thiadiazin-3-ylmethyl)phenyl]carbamate, m.p. 183°;

[1394] (4-hydroxy-1-piperidyl)ethyl N-[-4-(3,6-dihydro-5-(3,4-dimethoxyphenyl)-2-oxo-2H-1,3,4-thiadiazin-3-ylmethyl)phenyl]carbamate;

[1395] 2-morpholinoethyl N-[4-(3,6-dihydro-5-(3,4-dimethoxyphenyl)-2-oxo-2H-1,3,4-thiadiazin-3-ylmethyl)phenyl]carbamate;

[1396] 3-morpholinopropyl N-[4-(3,5-dihydro-5-(3,4-dimethoxyphenyl)-2-oxo-2H-1,3,4-thiadiazin-3-ylmethyl)phenyl]carbamate;

[1397] 2-thiomorpholinoethyl N-[4-(3,6-dihydro-5-(3,4-dimethoxyphenyl)-2-oxo-2H-1,3,4-thiadiazin-3-ylmethyl)phenyl]carbamate;

[1398] 3-thiomorpholinopropyl N-[4-(3,6-dihydro-5-(3,4-dimethoxyphenyl)-2-oxo-2H-1,3,4-thiadiazin -3-ylmethylphenyl]carbamate;

[1399] 2-piperazinoethyl N-[4-(3,6-dihydro-5-(3,4-dimethoxyphenyl)-2-oxo-2H-1,3,4-thiadiazin-3-ylmethyl)phenyl]carbamate;

[1400] 3-piperazinopropyl N-[4-(3,6-dihydro-5-(3,4-dimethoxyphenyl)-2-oxo-2H-1,3,4-thiadiazin-3-ylmethyl)phenyl]carbamate;

[1401] 2-pyrrolidinoethyl N-[4-(3,6-dihydro-5-(3,4-dimethoxyphenyl)-2-oxo-2H-1,3,4-thiadiazin-3-ylmethyl)phenyl]carbamate;

[1402] 3-pyrrolidinopropyl N-[4-(3,6-dihydro-5-(3,4-dimethoxyphenyl)-2-oxo-2H-1,3,4-thiadiazin-3-ylmethyl)phenyl]carbamate;

[1403] 3-(N,N-diethylamino)propyl N-[3-(3,6-dihydro-5-(3,4-dimethoxyphenyl)-2-oxo-2H-1,3,4-thiadiazin-3-ylmethyl)phenyl]carbamate, hydrochloride, m,p. 161°;

[1404] 2-(N,N-diethylamino)ethyl N-[3-(3,6-dihydro-5-(3,4-dimethoxyphenyl)-2-oxo-2H-1,3,4-thiadiazin-3-ylmethyl)phenyl]carbamate;

[1405] 2-(N,N-diisopropylamino)ethyl N-[3-(3,6-dihydro-5-(3,4-dimethoxyphenyl)-2-oxo-2H-1,3,4-thiadiazin-3-ylmethyl)phenyl]carbamate;

[1406] 6-(N,N-dimethylamino)hexyl N-[3-(3,6-dihydro-5-(3,4-dimethoxyphenyl)-2-oxo-2H-1,3,4-thiadiazin-3-ylmethyl)phenyl]carbamate;

[1407] 2-(N,N-dimethylamino)-1-methylethyl N-[3-(3,6-dihydro-5-(3,4-dimethoxyphenyl)-2-oxo-2H-1,3,4-thiadiazin-3-ylmethyl)phenyl]carbamate;

[1408] 1-methyl-4-piperidyl N-[3-(3,6-dihydro-5-(3,4-dimethoxyphenyl)-2-oxo-2H-1,3,4-thiadiazin-3-ylmethyl)phenyl]carbamate;

[1409] 2-morpholinoethyl N-[3-(3,6-dihydro-5-(3,4-dimethoxyphenyl)-2-oxo-2H-1,3,4-thiadiazin-3-ylmethyl)phenyl]carbamate;

[1410] 3-morpholinopropyl N-[3-(3,6-dihydro-5-(3,4-dimethoxyphenyl)-2-oxo-2H-1,3,4-thiadiazin-3-ylmethyl)phenyl]carbamate;

[1411] 2-thiomorpholinoethyl N-[3-(3,6-dihydro-5-(3,4-dimethoxyphenyl)-2-oxo-2-1,3,4-thiadiazin-3-ylmethyl)phenyl]carbamate;

[1412] 3-thiomorpholinopropyl N-[3-(3,6-dihydro-5-(3,4-dimethoxyphenyl)-2-oxo-2H-1,3,4-thiadiazin-3-ylmethyl)phenyl]carbamate;

[1413] 2-piperazinoethyl N-[3-(3,6-dihydro-5-(3,4-dimethoxyphenyl)-2-oxo-2H -1,3,4-thiadiazin-3-ylmethyl)phenyl]carbamate;

[1414] 3-piperazinopropyl N-[3-(3,6-dihydro-5-(3,4-dimethoxyphenyl)-2-oxo-2H-1,3,4-thiadiazin-3-ylmethyl)phenyl]carbamate;

[1415] 2-pyrrolidinoethyl N-[3-(3,6-dihydro-5-(3,4-dimethoxyphenyl)-2-oxo-2H-1,3,4-thiadiazin-3-ylmethyl)phenyl]carbamate;

[1416] 3-pyrrolidinopropyl N-[3-(3,6-dihydro-5-(3,4-dimethoxyphenyl)-2-oxo-2H-1,3,4-thiadiazin-3-ylmethyl)phenyl]carbamate;

[1417] 3-(N,N-diethylamino)propyl N-[4-(3,6-dihydro-5-(3-ethoxy-4-methoxyphenyl)-2-oxo-2H-1,3,4-thiadiazin-3-ylmethyl)phenyl]carbamate;

[1418] 2-(N,N-diethylamino)ethyl N-[4-(3,6-dihydro-5-(3-ethoxy-4-methoxyphenyl)-2-oxo-2H-1,3,4-thiadiazin-3-ylmethyl)phenyl]carbamate;

[1419] 2-(N,N-diisopropylamino)ethyl N-[4-(3,6-dihydro-5-(3-ethoxy-4-methoxyphenyl)-2-oxo-2H-1,3,4-thiadiazin-3-ylmethyl)phenyl]carbamate;

[1420] 6-(N,N-dimethylamino)hexyl N-[4-(3,6-dihydro-5-(3-ethoxy-4-methoxyphenyl)-2-oxo-2H-1,3,4-thiadiazin-3-ylmethyl)phenyl]carbamate;

[1421] 2-(N,N-dimethylamino)-1-methylethyl N-[4-(3,6-dihydro-5-(3-ethoxy-4-methoxyphenyl)-2-oxo-2H-1,3,4-thiadiazin-3-ylmethyl)phenyl]carbamate;

[1422] 1-methyl-4-piperidyl N-[4-(3,6-dihydro-5-(3-ethoxy-4-methoxyphenyl)-2-oxo-2H-1,3,4-thiadiazin-3-ylmethyl)phenyl]carbamate, m.p. 153;

[1423] 2-morpholinoethyl N-[4-(3,6-dihydro-5-(3-ethoxy-4-methoxyphenyl)-2-oxo-2H-1,3,4-thiadiazin-3-ylmethyl)phenyl]carbamate;

[1424] 3-morpholinopropyl N-[4-(3,6-dihydro-5-(3-ethoxy-4-methoxyphenyl)-2-oxo-2H-1,3,4-thiadiazin-3-ylmethyl)phenyl]carbamate;

[1425] 2-thiomorpholinoethyl N-[4-(3,6-dihydro-5-(3-ethoxy-4-methoxyphenyl)-2-oxo-2H-1,3,4-thiadiazin-3-ylmethyl)phenyl]carbamate;

[1426] 3-thiomorpholinopropyl N-[4-(3,6-dihydro-5-(3-ethoxy-4-methoxyphenyl)-2-oxo-2H-1,3,4-thiadiazin-3-ylmethyl)phenyl]carbamate;

[1427] 2-piperazinoethyl N-[4-(3,6-dihydro-5-(3-ethoxy-4-methoxyphenyl)-2-oxo-2H-1,3,4-thiadiazin-3ylmethyl)phenyl]carbamate;

[1428] 3-piperazinopropyl N-[4-(3,6-dihydro-5-(3-ethoxy-4-methoxyphenyl)-2-oxo-2H-1,3,4-thiadiazin-3-ylmethyl)phenyl]carbamate;

[1429] 2-pyrrolidinoethyl N-[4-(3,6-dihydro-5-(3-ethoxy-4-methoxyphenyl)-2-oxo-2H-1,3,4-thiadiazin-3-ylmethyl)phenyl]carbamate;

[1430] 3-pyrrolidinopropyl N-[4-(3,6-dihydro-5-(3-ethoxy-4-methoxyphenyl)-2-oxo-2H-1,3,4-thiadiazin-3-ylmethyl)phenyl]carbamate;

[1431] 3-(N,N-diethylamino)propyl N-[4-(3,6-dihydro-5-(3,4-dimethoxyphenyl)-6-ethyl-2-oxo-2H-1,3,4-thiadiazin-3-ylmethyl)phenyl]carbamate;

[1432] 2-(N,N-diethylamino)ethyl N-[4-(3,6-dihydro-5-(3,4-dimethoxyphenyl)-6-ethyl-2-oxo-2H-1,3,4-thiadiazin-3-ylmethyl)phenyl]carbamate;

[1433] 2-(N,N-diisopropylamino)ethyl N-[4-(3,6-dihydro-5-(3,4-dimethoxyphenyl)-6-ethyl-2-oxo-2H-1,3,4-thiadiazin-3-ylmethyl)phenyl]carbamate;

[1434] 6-(N,N-dimethylamino)hexyl N-[4-(3,6-dihydro-5-(3,4-dimethoxyphenyl)-6-ethyl-2-oxo-2H-1,3,4-thiadiazin-3-ylmethyl)phenyl]carbamate;

[1435] 2-(N,N-dimethylamino)-1-methylethyl N-[4-(3,6-dihydro-5-(3,4-dimethoxyphenyl)-6-ethyl-2-oxo-2H-1,3,4-thiadiazin-3-ylmethyl)phenyl]carbamate;

[1436] 1-methyl-4-piperidyl N-[4-(3,6-dihydro-5-(3,4-dimethoxyphenyl)-6-ethyl-2-oxo-2H-1,3,4-thiadiazin-3-ylmethyl)phenyl]carbamate;

[1437] 2-morpholinoethyl N-[4-(3,6-dihydro-5-(3,4-dimethoxyphenyl)-6-ethyl-2-oxo-2H-1,3,4-thiadiazin-3-ylmethyl)phenyl]carbamate;

[1438] 3-morpholinopropyl N-[4-(3,6-dihydro-5-(3,4-dimethoxyphenyl)-6-ethyl-2-oxo-2H-1,3,4-thiadiazin-3-ylmethyl)phenyl]carbamate;

[1439] 2-thiomorpholinoethyl N-[4-(3,6-dihydro-5-(3,4-dimethoxyphenyl)-6-ethyl-2-oxo-2H-1,3,4-thiadiazin-3-ylmethyl)phenyl]carbamate;

[1440] 3-thiomorpholinopropyl N-[4-(3,6-dihydro-5-(3,4-dimethoxyphenyl)-6-ethyl-2-oxo-2H-1,3,4-thiadiazin-3-ylmethyl)phenyl]carbamate;

[1441] 2-piperazinoethyl N-[4-(3,6-dihydro-5-(3,4dimethoxyphenyl)-6-ethyl-2-oxo-2H-1,3,4-thiadiazin-3-ylmethyl)phenyl]carbamate;

[1442] 3-piperazinopropyl N-[4-(3,6-dihydro-5-(3,4-dimethoxyphenyl)-6-ethyl-2-oxo-2H-1,3,4-thiadiazin-3-ylmethyl)phenyl]carbamate;

[1443] 2-pyrrolidinoethyl N-[4-(3,6-dihydro-5-(3,4-dimethoxyphenyl)-6-ethyl-2-oxo-2H-1,3,4-thiadiazin-3-ylmethyl)phenyl]carbamate;

[1444] 3-pyrrolidinopropyl N-[4-(3,6-dihydro-5-(3,4-dimethoxyphenyl)-6-ethyl-2-oxo-2H-1,3,4-thiadiazin-3-ylmethyl)phenyl]carbamate;

[1445] 3-(N,N-diethylamino)propyl N-[4-(3,6-dihydro-5-(3-ethoxy-4-methoxyphenyl)-6-ethyl-2oxo-2H-1,3,4-thiadiazin-3-ylmethyl)phenyl]carbamate;

[1446] 2-(N,N-diethylamino)ethyl N-[4-(3,6-dihydro-5-(3-ethoxy-4-methoxyphenyl)-6-ethyl-2-oxo-2H-1,3,4-thiadiazin-3-ylmethyl)phenyl]carbamate;

[1447] 2-(N,N-diisopropylamino)ethyl N-[4-(3,6-dihydro-5-(3-ethoxy-4-methoxyphenyl)-6-ethyl-2-oxo-2H-1,3,4-thiadiazin-3-ylmethyl)phenyl]carbamate;

[1448] 6-(N,N-dimethylamino)hexyl N-[4-(3,6-dihydro-5-(3-ethoxy-4-methoxyphenyl)-6-ethyl-2-oxo-2H-1,3,4-thiadiazin-3-ylmethyl)phenyl]carbamate;

[1449] 2-(N,N-dimethylamino)-1-methylethyl N-[4-(3,6-dihydro-5-(3-ethoxy-4-methoxyphenyl)-6-ethyl-2-oxo-2H-1,3,4-thiadiazin-3-ylmethyl)phenyl]carbamate;

[1450] 1-methyl-4-piperidyl N-[4-(3,6-dihydro-5-(3-ethoxy-4-methoxyphenyl)-6-ethyl-2-oxo-2H-1,3,4-thiadiazin-3-ylmethyl)phenyl]carbamate;

[1451] 2-morpholinoethyl N-[4-(3,6-dihydro-5-(3-ethoxy-4-methoxyphenyl)-6-ethyl-2-oxo-2H-1,3,4-thiadiazin-3-ylmethyl)phenyl]carbamate;

[1452] 3-morpholinopropyl-2-oxo-2H-1,3,4-thiadiazin-3-ylmethyl)phenyl]carbamate;

[1453] 2-thiomorpholinoethyl N-[4-(3,6-dihydro-5-(3-ethoxy-4-methoxyphenyl)-6-ethyl-2-oxo-2H-1,3,4-thiadiazin-3-ylmethyl)phenyl]carbamate;

[1454] 3-thiomorpholinopropyl N-[4-(3,6-dihydro-5-(3-ethoxy-4-methoxyphenyl)-6-ethyl-2-oxo-2H-1,3,4-thiadiazin-3-ylmethyl)phenyl]carbamate;

[1455] 2-piperazinoethyl N-[4-(3,6-dihydro-5-(3-ethoxy-4-methoxyphenyl)-6-ethyl-2-oxo-2H-1,3,4-thiadiazin-3-ylmethyl)phenyl]carbamate;

[1456] 3-piperazinopropyl N-[4-(3,6-dihydro-5-(3-ethoxy-4-methoxyphenyl)-6-ethyl-2-oxo-2H-1,3,4-thiadiazin-3-ylmethyl)phenyl]carbamate;

[1457] 2-pyrrolidinoethyl N-[4-(3,6-dihydro-5-(3-ethoxy-4-methoxyphenyl)-6-ethyl-2-oxo-2H-1,3,4-thiadiazin-3-ylmethyl)phenyl]carbamate;

[1458] 3-pyrrolidinopropyl N-[4-(3,6-dihydro-5-(3-ethoxy-4-methoxyphenyl)-6-ethyl-2-oxo-2H-1,3,4-thiadiazin-3-ylmethyl)phenyl]carbamate;

[1459] 3-(N,N-diethylamino)propyl N-[4-(3,6-dihydro-5-(3-cyclopentyloxy-4-methoxyphenyl)-2-oxo-2H-1,3,4-thiadiazin-3-ylmethyl)phenyl]carbamate;

[1460] 2-(N,N-diethylamino)ethyl N-[4-(3,6-dihydro-5-(3-cyclopentyloxy-4-methoxyphenyl)-2-oxo-2H-1,3,4-thiadiazin-3-ylmethyl)phenyl]carbamate;

[1461] 2-(N,N-diisopropylamino)ethyl N-[4-(3,6-dihydro-5-(3-cyclopentyloxy-4-methoxyphenyl)-2oxo-2H-1,3,4-thiadiazin-3-ylmethyl)phenyl]carbamate;

[1462] 6-(N,N-dimethylamino)hexyl N-[4-(3,6-dihydro-5-(3-cyclopentyloxy-4-methoxyphenyl)-2-oxo-2H-1,3,4-thiadiazin-3-ylmethyl)phenyl]carbamate;

[1463] 2-(N,N-dimethylamino)-1-methylethyl N-[4-(3,6-dihydro-5-(3-cyclopentyloxy-4-methoxyphenyl)-2-oxo-2H-1,3,4-thiadiazin-3-ylmethyl)phenyl]carbamate;

[1464] 1-methyl-4-piperidyl N-[4-(3,6-dihydro-5-(3-cyclopentyloxy-4-methoxyphenyl)-2-oxo-2H-1,3,4-thiadiazin-3-ylmethyl)phenyl]carbamate;

[1465] 2-morpholinoethyl N-[4-(3,6-dihydro-5-(3-cyclopentyloxy-4-methoxyphenyl)-2-oxo-2H-1,3,4-thiadiazin-3-ylmethyl)phenyl]carbamate;

[1466] 3-morpholinopropyl N-[4-(3,6-dihydro-5-(3-cyclopentyloxy-4-methoxyphenyl)-2-oxo-2H-1,3,4-thiadiazin-3-ylmethyl)phenyl]carbamate;

[1467] 2-thiomorpholinoethyl N-[4-(3,6-dihydro-5-(3-cyclopentyloxy-4-methoxyphenyl)-2-oxo-2H-1,3,4-thiadiazin-3-ylmethyl)phenyl]carbamate;

[1468] 3-thiomorpholinopropyl N-[4-(3,6-dihydro-5-(3-cyclopentyloxy-4-methoxyphenyl)-2-oxo-2H-1,3,4-thiadiazin-3-ylmethyl)phenyl]carbamate;

[1469] 2-piperazinoethyl N-[4-(3,6-dihydro-5-(3-cyclopentyloxy-4-methoxyphenyl)-2-oxo-2H-1,3,4-thiadiazin-3-ylmethyl)phenyl]carbamate;

[1470] 3-piperazinopropyl N-[4-(3,6-dihydro-5-(3-cyclopentyloxy-4-methoxyphenyl)-2-oxo-2H-1,3,4-thiadiazin-3-ylmethyl)phenyl]carbamate;

[1471] 2-pyrrolidinoethyl N-[4-(3,6-dihydro-5-(3-cyclopentyloxy-4-methoxyphenyl)-2-oxo-2H-1,3,4-thiadiazin-3-ylmethyl)phenyl]carbamate;

[1472] 3-pyrrolidinopropyl N-[4-(3,6-dihydro-5-(3-cyclopentyloxy-4-methoxyphenyl)-2-oxo-2H-1,3,4-thiadiazin-3-ylmethyl)phenyl]carbamate;

[1473] 3-(N,N-diethylamino)propyl N-[4-(3,6-dihydro-5-(3-propoxy-4-methoxyphenyl)-2-oxo-2H-1,3,4-thiadiazin-3-ylmethyl)phenyl]carbamate;

[1474] 2-(N,N-diethylamino)ethyl N-[4-(3,6-dihydro-5-(3-propoxy-4-methoxyphenyl)-2-oxo-2H-1,3,4-thiadiazin-3-ylmethyl)phenyl]carbamate;

[1475] 2-(N,N-diisopropylamino)ethyl N-[4-(3,6-dihydro-5-(3-propoxy-4-methoxyphenyl)-2-oxo-2H-1,3,4-thiadiazin-3-ylmethyl)phenyl]carbamate;

[1476] 6-(N,N-dimethylamino)hexyl N-[4-(3,6-dihydro-5-(3-propoxy-4-methoxyphenyl)-2-oxo-2H-1,3,4-thiadiazin-3-ylmethyl)phenyl]carbamate;

[1477] 2-(N,N-dimethylamino)-1-methylethyl N-[4-(3,6-dihydro-5-(3-propoxy-4-methoxyphenyl)-2-oxo-2H-1,3,4-thiadiazin-3-ylmethyl)phenyl]carbamate;

[1478] 1-methyl-4-piperidyl N-[4-(3,6-dihydro-5-(3-propoxy-4-methoxyphenyl)-2-oxo-2H-1,3,4-thiadiazin-3-ylmethyl)phenyl]carbamate;

[1479] 2-morpholinoethyl N-[4-(3,6-dihydro-5-(3-propoxy-4-methoxyphenyl)-2-oxo-2H-1,3,4-thiadiazin-3-ylmethyl)phenyl]carbamate;

[1480] 3-morpholinopropyl N-[4-(3,6-dihydro-5-(3-propoxy-4-methoxyphenyl)-2-oxo-2H-1,3,4-thiadiazin-3-ylmethyl)phenyl]carbamate;

[1481] 2-thiomorpholinoethyl N-[4-(3,6-dihydro-5-(3-propoxy-4-methoxyphenyl)-2-oxo-2H-1,3,4-thiadiazin-3-ylmethyl)phenyl]carbamate;

[1482] 3-thiomorpholinopropyl N-[4-(3,6-dihydro-5-(3-propoxy-4-methoxyphenyl)-2-oxo-2H-1,3,4-thiadiazin-3-ylmethyl)phenyl]carbamate;

[1483] 2-piperazinoethyl N-[4-(3,6-dihydro-5-(3-propoxy-4-methoxyphenyl)-2-oxo-2H-1,3,4-thiadiazin-3-ylmethyl)phenyl]carbamate;

[1484] 3-piperazinopropyl N-[4-(3,6-dihydro-5-(3-propoxy-4-methoxyphenyl)-2-oxo-2H-1,3,4-thiadiazin-3-ylmethyl)phenyl]carbamate;

[1485] 2-pyrrolidinoethyl N-[4-(3,6-dihydro-5-(3-propoxy-4-methoxyphenyl)-2-oxo-2H-1,3,4-thiadiazin-3-ylmethyl)phenyl]carbamate;

[1486] 3-pyrrolidinopropyl N-[4-(3,6-dihydro-5-(3-propoxy-4-methoxyphenyl)-2-oxo-2H-1,3,4-thiadiazin-3-ylmethyl)phenyl]carbamate;

[1487] 3-(N,N-diethylamino)propyl N-[4-(3,-dihydro-5-(3-isopropoxy-4-methoxyphenyl)-2-oxo-2H-1,3,4-thiadiazin-3-ylmethyl)phenyl]carbamate;

[1488] 2-(N,N-diethylamino)ethyl N-[4-(3,6-dihydro-5-(3-isopropoxy-4-methoxyphenyl)-2-oxo-2H-1,3,4-thiadiazin-3-ylmethyl)phenyl]carbamate;

[1489] 2-(N,N-diisopropylamino)ethyl N-[4-(3,6-dihydro-5-(3-isopropoxy-4-methoxyphenyl)-2-oxo-2H-1,3,4-thiadiazin-3-ylmethyl)phenyl]carbamate;

[1490] 6-(N,N-dimethylamino)hexyl N-[4-(3,6-dihydro-5-(3-isopropoxy-4-methoxyphenyl)-2-oxo-2H-1,3,4-thiadiazin-3-ylmethyl)phenyl]carbamate;

[1491] 2-(N,N-dimethylamino)-1-methylethyl N-[4-(3,6-dihydro-5-(3-isopropoxy-4-methoxyphenyl)-2-oxo-2H-1,3,4-thiadiazin-3-ylmethyl)phenyl]carbamate;

[1492] 1-methyl-4-piperidyl N-[4-(3,6-dihydro-5-(3-isopropoxy-4-methoxyphenyl)-2-oxo-2H-1,3,4-thiadiazin-3-ylmethyl)phenyl]carbamate;

[1493] 2-morpholinoethyl N-[4-(3,6-dihydro-5-(3-isopropoxy-4-methoxyphenyl)-2-oxo-2H-1,3,4-thiadiazin-3-ylmethyl)phenyl]carbamate;

[1494] 3-morpholinopropyl N-[4-(3,6-dihydro-5-(3-isopropoxy-4-methoxyphenyl)-2-oxo-2H-1,3,4-thiadiazin-3-ylmethyl)phenyl]carbamate;

[1495] 2-thiomorpholinoethyl N-[4-(3,6-dihydro-5-(3-isopropoxy-4-methoxyphenyl)-2-oxo-2H-1,3,4-thiadiazin-3-ylmethyl)phenyl]carbamate;

[1496] 3-thiomorpholinopropyl N-[4-(3,6-dihydro-5-(3-isopropoxy-4-methoxyphenyl)-2-oxo-2H-1,3,4-thiadiazin-3-ylmethyl)phenyl]carbamate;

[1497] 2-piperazinoethyl N-[4-(3,6-dihydro-5-(3-isopropoxy-4-methoxyphenyl)-2-oxo-2H-1,3,4-thiadiazin-3-ylmethyl)phenyl]carbamate;

[1498] 3-piperazinopropyl N-[4-(3,6-dihydro-5-(3-isopropoxy-4-methoxyphenyl)-2-oxo-2H-1,3,4-thiadiazin-3-ylmethyl)phenyl]carbamate;

[1499] 2-pyrrolidinoethyl N-[4-(3,6-dihydro-5-(3-isopropoxy-4-methoxyphenyl)-2-oxo-2H-1,3,4-thiadiazin-3-ylmethyl)phenyl]carbamate;

[1500] 3-pyrrolidinopropyl N-[4-(3,6-dihydro-5-(3-isopropoxy-4-methoxyphenyl)-2-oxo-2H-1,3,4-thiadiazin-3-ylmethyl)phenyl]carbamate;

[1501] 3-(N,N-diethylamino)propyl N-[4-(3,6-dihydro-5-(3-fluoromethoxy-4-methoxyphenyl)-2-oxo-2H-1,3,4-thiadiazin-3-ylmethyl)phenyl]carbamate;

[1502] 2-(N,N-diethylamino)ethyl N-[4-(3,6-dihydro-5-(3-fluoromethoxy-4-methoxyphenyl)-2-oxo-2H-1,3,4-thiadiazin-3-ylmethyl)phenyl]carbamate;

[1503] 2-(N,N-diisopropylamino)ethyl N-[4-(3,6-dihydro-5-(3-fluoromethoxy-4-methoxyphenyl)-2-oxo-2H-1,3,4-thiadiazin-3-ylmethyl)phenyl]carbamate;

[1504] 6-(N,N-dimethylamino)hexyl N-[4-(3,6-dihydro-5-(3-fluoromethoxy-4-methoxyphenyl)-2-oxo-2H-1,3,4-thiadiazin-3-ylmethyl)phenyl]carbamate;

[1505] 2-(N,N-dimethylamino)-1-methylethyl N-[4-(3,6-dihydro-5-(3-fluoromethoxy-4-methoxyphenyl)-2-oxo-2H-1,3,4-thiadiazin-3-ylmethyl)phenyl]carbamate;

[1506] 1-methyl-4-piperidyl N-[4-(3,6-dihydro-5-(3-fluoromethoxy-4-methoxyphenyl)-2-oxo-2H-1,3,4-thiadiazin-3-ylmethyl)phenyl]carbamate;

[1507] 2-morpholinoethyl N-[4-(3,6-dihydro-5-(3-fluoromethoxy-4-methoxyphenyl)-2-oxo-2H-1,3,4-thiadiazin-3-ylmethyl)phenyl]carbamate;

[1508] 3-morpholinopropyl N-[4-(3,6-dihydro-5-(3-fluoromethoxy-4-methoxyphenyl)-2-oxo-2H-1,3,4-thiadiazin-3-ylmethyl)phenyl]carbamate;

[1509] 2-thiomorpholinoethyl N-[4-(3,6-dihydro-5-(3-fluoromethoxy-4-methoxyphenyl)-2-oxo-2H-1,3,4-thiadiazin-3-ylmethyl)phenyl]carbamate;

[1510] 3-thiomorpholinopropyl N-[4-(3,6-dihydro-5-(3-fluoromethoxy-4-methoxyphenyl)-2-oxo-2H-1,3,4-thiadiazin-3-ylmethyl)phenyl]carbamate;

[1511] 2-piperazinoethyl N-[4-(3,6-dihydro-5-(3-fluoromethoxy-4-methoxyphenyl)-2-oxo-2H-1,3,4-thiadiazin-3-ylmethyl)phenyl]carbamate;

[1512] 3-piperazinopropyl N-[4-(3,6-dihydro-5-(3-fluoromethoxy-4-methoxyphenyl)-2-oxo-2H-1,3,4-thiadiazin-3-ylmethyl)phenyl]carbamate;

[1513] 2-pyrrolidinoethyl N-[4-(3,6-dihydro-5-(3-fluoromethoxy-4-methoxyphenyl)-2-oxo-2H-1,3,4-thiadiazin-3-ylmethyl)phenyl]carbamate;

[1514] 3-pyrrolidinopropyl N-[4-(3,6-dihydro-5-(3-fluoromethoxy-4-methoxyphenyl)-2-oxo-2H-1,3,4-thiadiazin-3-ylmethyl)phenyl]carbamate;

[1515] N-[4-(3,6-dihydro-5-(3,4-dimethoxyphenyl)-2-oxo-2H-1,3,4-thiadiazin-3-ylmethyl)phenyl]-2-morpholinoacetamide;

[1516] N-[4-(3,6-dihydro-5-(3,4-dimethoxyphenyl)-2-oxo-2H-1,3,4-thiadiazin-3-ylmethyl)phenyl]-2-(N,N-diethylamino)acetamide;

[1517] N-[4-(3,6-dihydro-5-(3,4-dimethoxyphenyl)-2-oxo-2H-1,3,4-thiadiazin-3-ylmethyl)phenyl]-2-(N,N-diisopropylamino)acetamide;

[1518] N-[4-(3,6-dihydro-5-(3,4-dimethoxyphenyl)-2-oxo-2H-1,3,4-thiadiazin-3-ylmethyl)phenyl]-2-thiomorpholinoacetamide;

[1519] N-[4-(3,6-dihydro-5-(3,4-dimethoxyphenyl)-2-oxo-2H-1,3,4-thiadiazin-3-ylmethyl)phenyl]-2-piperidinoacetamide;

[1520] N-[4-(3,6-dihydro-5-(3,4-dimethoxyphenyl)-2-oxo-2H-1,3,4-thiadiazin-3-ylmethyl)phenyl]-2-(4-hydroxypiperidino)acetamide;

[1521] N-[4-(3,6-dihydro-5-(3,4-dimethoxyphenyl)-2-oxo-2H-1,3,4-thiadiazin-3-ylmethyl)phenyl]-2-piperazinoacetamide;

[1522] N-[4-(3,6-dihydro-5-(3,4-dimethoxyphenyl)-2-oxo-2H-1,3,4-thiadiazin-3-ylmethyl)phenyl]-2-(4-methylpiperazino)acetamide;

[1523] N-[4-(3,6-dihydro-5-(3,4-dimethoxyphenyl)-2-oxo-2H-1,3,4-thiadiazin-3-ylmethyl)phenyl]-2-pyrrolidinoacetamide;

[1524] N-[3-(3,6-dihydro-5-(3,4-dimethoxyphenyl)-2-oxo-2H-1,3,4-thiadiazin-3-ylmethyl)phenyl]-2-(4-morpholinyl)acetamide;

[1525] N-[3-(3,6-dihydro-5-(3,4-dimethoxyphenyl)-2-oxo-2H-1,3,4-thiadiazin-3-ylmethyl)phenyl]-2-(N,N-diethylamino)acetamide;

[1526] N-[3-(3,6-dihydro-5-(3,4-dimethoxyphenyl)-2-oxo-2H-1,3,4-thiadiazin-3-ylmethyl)phenyl]-2-(N,N-diisopropylamino)acetamide;

[1527] N-[3-(3,6-dihydro-5-(3,4-dimethoxyphenyl)-2-oxo-2H-1,3,4-thiadiazin-3-ylmethyl)phenyl]-2-thiomorpholinoacetamide;

[1528] N-[3-(3,6-dihydro-5-(3,4-dimethoxyphenyl)-2-oxo-2H-1,3,4-thiadiazin-3-ylmethyl)phenyl]-2-piperidinoacetamide;

[1529] N-[3-(3,6-dihydro-5-(3,4-dimethoxyphenyl)-2-oxo-2H-1,3,4-thiadiazin-3-ylmethyl)phenyl]-2-(4-hydroxypiperidino)acetamide;

[1530] N-[3-(3,6-dihydro-5-(3,4-dimethoxyphenyl)-2-oxo-2H-1,3,4-thiadiazin-3-ylmethyl)phenyl]-2-piperazinoacetamide;

[1531] N-[3-(3,6-dihydro-5-(3,4-dimethoxyphenyl)-2-oxo-2H-1,3,4-thiadiazin-3-ylmethyl)phenyl]-2-(4-methylpiperazino)acetamide;

[1532] N-[3-(3,6-dihydro-5-(3,4-dimethoxyphenyl)-2-oxo-2H-1,3,4-thiadiazin-3-ylmethyl)phenyl]-2-pyrrolidinoacetamide;

[1533] N-[4-(3,6-dihydro-5-(3,4-dimethoxyphenyl)-2-oxo-2H-1,3,4-thiadiazin-3-ylmethyl)phenyl]-3-(4-morpholinyl)propionamide;

[1534] N-[4-(3,6-dihydro-5-(3,4-dimethoxyphenyl)-2-oxo-2H-1,3,4-thiadiazin-3-ylmethyl)phenyl]-3-(N,N-diethylamino)propionamide;

[1535] N-[4-(3,6-dihydro-5-(3,4-dimethoxyphenyl)-2-oxo-2H-1,3,4-thiadiazin-3-ylmethyl)phenyl]-3-(N,N-diisopropylamino)propionamide;

[1536] N-[4-(3,6-dihydro-5-(3,4-dimethoxyphenyl)-2-oxo-2H-1,3,4-thiadiazin-3-ylmethyl)phenyl]-3-thiomorpholinopropionamide;

[1537] N-[4-(3,6-dihydro-5-(3,4-dimethoxyphenyl)-2-oxo-2H-1,3,4-thiadiazin-3-ylmethyl)phenyl]-3-piperidinopropionamide;

[1538] N-[4-(3,6-dihydro-5-(3,4-dimethoxyphenyl)-2-oxo-2H-1,3,4-thiadiazin-3-ylmethyl)phenyl]-3-(4-hydroxypiperidino)propionamide;

[1539] N-[4-(3,6-dihydro-5-(3,4-dimethoxyphenyl)-2-oxo-2H-1,3,4-thiadiazin-3-ylmethyl)phenyl]-3-piperazinopropionamide;

[1540] N-[4-(3,6-dihydro-5-(3,4-dimethoxyphenyl)-2-oxo-2H-1,3,4-thiadiazin-3-ylmethyl)phenyl]-3-pyrrolidinopropionamide;

[1541] N-[4-(3,6-dihydro-5-(3-ethoxy-4-methoxyphenyl)-2-oxo-2H-1,3,4-thiadiazin-3-ylmethyl)phenyl]-2-(4-morpholinyl)acetamide;

[1542] N-[4-(3,6-dihydro-5-(3-ethoxy-4-methoxyphenyl)-2-oxo-2H-1,3,4-thiadiazin-3-ylmethyl)phenyl]-2-(N,N-diethylamino)acetamide;

[1543] N-[4-(3,6-dihydro-5-(3-ethoxy-4-methoxyphenyl)-2-oxo-2H-1,3,4-thiadiazin-3-ylmethyl)phenyl]-2-(N,N-diisopropylamino)acetamide;

[1544] N-[4-(3,6-dihydro-5-(3-ethoxy-4-methoxyphenyl)-2-oxo-2H-1,3,4-thiadiazin-3-ylmethyl)phenyl]-2-thiomorpholinoacetamide;

[1545] N-[4-(3,6-dihydro-5-(3-ethoxy-4-methoxyphenyl)-2-oxo-2H-1,3,4-thiadiazin-3-ylmethyl)phenyl]-2-piperidinoacetamide;

[1546] N-[4-(3,6-dihydro-5-(3-ethoxy-4-methoxyphenyl)-2-oxo-2H-1,3,4-thiadiazin-3-ylmethyl)phenyl]-2-(4-hydroxypiperidino)acetamide;

[1547] N-[4-(3,6-dihydro-5-(3-ethoxy-4-methoxyphenyl)-2-oxo-2H-1,3,4-thiadiazin-3-ylmethyl)phenyl]-2-piperazinoacetamide;

[1548] N-[4-(3,6-dihydro-5-(3-ethoxy-4-methoxyphenyl)-2-oxo-2H-1,3,4-thiadiazin-3-ylmethyl)phenyl]-2-pyrrolidinoacetamide;

[1549] N-[4-(3,6-dihydro-5-(3-propoxy-4-methoxyphenyl)-2-oxo-2H-1,3,4-thiadiazin-3-ylmethyl)phenyl]-2-(4-morpholinyl)acetamide;

[1550] N-[4-(3,6-dihydro-5-(3-propoxy-4-methoxyphenyl)-2-oxo-2H-1,3,4-thiadiazin-3-ylmethyl)phenyl]-2-(N,N-diethylamino)acetamide;

[1551] N-[4-(3,6-dihydro-5-(3-propoxy-4-methoxyphenyl)-2-oxo-2H-1,3,4-thiadiazin-3-ylmethyl)phenyl]-2-(N,N-diisopropylamino)acetamide;

[1552] N-[4-(3,6-dihydro-5-(3-propxoy-4-methoxyphenyl)-2-oxo-2H-1,3,4-thiadiazin-3-ylmethyl)phenyl]-2-thiomorpholinoacetamide;

[1553] N-[4-(3,6-dihydro-5-(3-propoxy-4-methoxyphenyl)-2-oxo-2H-1,3,4-thiadiazin-3-ylmethyl)phenyl]-2-piperidinoacetamide;

[1554] N-[4-(3,6-dihydro-5-(3-propoxy-4-methoxyphenyl)-2-oxo-2H-1,3,4-thiadiazin-3-ylmethyl)phenyl]-2-(4-hydroxypiperidino)acetamide;

[1555] N-[4-(3,6-dihydro-5-(3-propoxy-4-methoxyphenyl)-2-oxo-2H-1,3,4-thiadiazin-3-ylmethyl)phenyl]-2-piperazinoacetamide;

[1556] N-[4-(3,6-dihydro-5-(3-propoxy-4-methoxyphenyl)-2-oxo-2H-1,3,4-thiadiazin-3-ylmethyl)phenyl]-2-pyrrolidinoacetamide;

[1557] N-[4-(3,6-dihydro-5-(3-isopropoxy-4-methoxyphenyl)-2-oxo-2H-1,3,4-thiadiazin-3-ylmethyl)phenyl]-2-(4-morpholinyl)acetamide;

[1558] N-[4-(3,6-dihydro-5-(3-isopropoxy-4-methoxyphenyl)-2-oxo-2H-1,3,4-thiadiazin-3-ylmethyl)phenyl]-2-(N,N-diethylamino)acetamide;

[1559] N-[4-(3,6-dihydro-5-(3-isopropoxy-4-methoxyphenyl)-2-oxo-2H-1,3,4-thiadiazin-3-ylmethyl)phenyl]-2-(N,N-diisopropylamino)acetamide;

[1560] N-[4-(3,6-dihydro-5-(3-isopropoxy-4-methoxyphenyl)-2-oxo-2H-1,3,4-thiadiazin-3-ylmethyl)phenyl]-2-thiomorpholinoacetamide;

[1561] N-[4-(3,6-dihydro-5-(3-isopropoxy-4-methoxyphenyl)-2-oxo-2H-1,3,4-thiadiazin-3-ylmethyl)phenyl]-2-piperidinoacetamide;

[1562] N-[4-(3,6-dihydro-5-(3-isopropoxy-4-methoxyphenyl)-2-oxo-2H-1,3,4-thiadiazin-3-ylmethyl)phenyl]-2-(4-hydroxypiperidino)acetamide;

[1563] N-[4-(3,6-dihydro-5-(3-isopropoxy-4-methoxyphenyl)-2-oxo-2H-1,3,4-thiadiazin-3-ylmethyl)phenyl]-2-piperazinoacetamide;

[1564] N-[4-(3,6-dihydro-5-(3-isopropoxy-4-methoxyphenyl)-2-oxo-2H-1,3,4-thiadiazin-3-ylmethyl)phenyl]-2-pyrrolidinoacetamide;

[1565] N-[4-(3,6-dihydro-5-(3-cyclopentyloxy-4-methoxyphenyl)-2-oxo-2H-1,3,4-thiadiazin-3-ylmethyl)phenyl]-2-(4-morpholinyl)acetamide;

[1566] N-[4-(3,6-dihydro-5-(3-cyclopentyloxy-4-methoxyphenyl)-2-oxo-2H-1,3,4-thiadiazin-3-ylmethyl)phenyl]-2-(N,N-diethylamino)acetamide;

[1567] N-[4-(3,6-dihydro-5-(3-cyclopentyloxy-4-methoxyphenyl)-2-oxo-2H-1,3,4-thiadiazin-3-ylmethyl)phenyl]-2-(N,N-diisopropylamino)acetamide;

[1568] N-[4-(3,6-dihydro-5-(3-cyclopentyloxy-4-methoxyphenyl)-2-oxo-2H-1,3,4-thiadiazin-3-ylmethyl)phenyl]-2-thiomorpholinoacetamide;

[1569] N-[4-(3,6-dihydro-5-(3-cyclopentyloxy-4-methoxyphenyl)-2-oxo-2H-1,3,4-thiadiazin-3-ylmethyl)phenyl]-2-piperidinoacetamide;

[1570] N-[4-(3,6-dihydro-5-(3-cyclopentyloxy-4-methoxyphenyl)-2-oxo-2H-1,3,4-thiadiazin-3-ylmethyl)phenyl]-2-(4-hydroxypiperidino)acetamide;

[1571] N-[4-(3,6-dihydro-5-(3-cyclopentyloxy-4-methoxyphenyl)-2-oxo-2H-1,3,4-thiadiazin-3-ylmethyl)phenyl]-2-pyrrolidinoacetamide;

[1572] N-[4-(3,6-dihydro-5-(3-ethoxy-4-methoxyphenyl)-2-oxo-2H-1,3,4-thiadiazin-3-ylmethyl)phenyl]-3-(4-morpholinyl)propionamide;

[1573] N-[4-(3,6-dihydro-5-(3-ethoxy-4-methoxyphenyl)-2-oxo-2H-1,3,4-thiadiazin-3-ylmethyl)phenyl]-3-(N,N-diethylamino)propionamide;

[1574] N-[4-(3,6-dihydro-5-(3-ethoxy-4-methoxyphenyl)-2-oxo-2H-1,3,4-thiadiazin-3-ylmethyl)phenyl]-3-(N,N-diisopropylamino)propionamide;

[1575] N-[4-(3,6-dihydro-5-(3-ethoxy-4-methoxyphenyl)-2-oxo-2H-1,3,4-thiadiazin-3-ylmethyl)phenyl]-3-thiomorpholinopropionamide;

[1576] N-[4-(3,6-dihydro-5-(3-ethoxy-4-methoxyphenyl)-2-oxo-2H-1,3,4-thiadiazin-3-ylmethyl)phenyl]-3-piperidinopropionamide;

[1577] N-[4-(3,6-dihydro-5-(3-ethoxy-4-methoxyphenyl)-2-oxo-2H-1,3,4-thiadiazin-3-ylmethyl)phenyl]-3-(4-hydroxypiperidino)propionamide;

[1578] N-[4-(3,6-dihydro-5-(3-ethoxy-4-methoxyphenyl)-2-oxo-2H-1,3,4-thiadiazin-3-ylmethyl)phenyl]-3-piperazinopropionamide;

[1579] N-[4-(3,6-dihydro-5-(3-ethoxy-4-methoxyphenyl)-2-oxo-2H-1,3,4-thiadiazin-3-ylmethyl)phenyl]-3-pyrrolidinopropionamide;

[1580] N-[4-(3,6-dihydro-5-(3-propoxy-4-methoxyphenyl)-2-oxo-2H-1,3,4-thiadiazin-3-ylmethyl)phenyl]-3-(4-morpholinyl)propionamide;

[1581] N-[4-(3,6-dihydro-5-(3-propoxy-4-methoxyphenyl)-2-oxo-2H-1,3,4-thiadiazin-3-ylmethyl)phenyl]-3-(N,N-diethylamino)propionamide;

[1582] N-[4-(3,6-dihydro-5-(3-propoxy-4-methoxyphenyl)-2-oxo-2H-1,3,4-thiadiazin-3-ylmethyl)phenyl]-3-(N,N-diisopropylamino)propionamide;

[1583] N-[4-(3,6-dihydro-5-(3-propoxy-4-methoxyphenyl)-2-oxo-2H-1,3,4-thiadiazin-3-ylmethyl)phenyl]-3-thiomorpholinopropionamide;

[1584] N-[4-(3,6-dihydro-5-(3-propoxy-4-methoxyphenyl)-2-oxo-2H-1,3,4-thiadiazin-3-ylmethyl)phenyl]-3-piperidinopropionamide;

[1585] N-[4-(3,6-dihydro-5-(3-propoxy-4-methoxyphenyl)-2-oxo-2H-1,3,4-thiadiazin-3-ylmethyl)phenyl]-3-(4-hydroxypiperidino)propionamide;

[1586] N-[4-(3,6-dihydro-5-(3-propoxy-4-methoxyphenyl)-2-oxo-2H-1,3,4-thiadiazin-3-ylmethyl)phenyl]-3-piperazinopropionamide;

[1587] N-[4-(3,6-dihydro-5-(3-propoxy-4-methoxyphenyl)-2-oxo-2H-1,3,4-thiadiazin-3-ylmethyl)phenyl]-3-pyrrolidinopropionamide.

[1588] N-[4-(3,6-dihydro-5-(3-isopropoxy-4-methoxyphenyl)-2-oxo-2H-1,3,4-thiadiazin-3-ylmethyl)phenyl]-3-(4-morpholinyl)propionamide;

[1589] N-[4-(3,6-dihydro-5-(3-isopropoxy-4-methoxyphenyl)-2-oxo-2H-1,3,4-thiadiazin-3-ylmethyl)phenyl]-3-(N,N-diethylamino)propionamide;

[1590] N-[4-(3,6-dihydro-5-(3-isopropoxy-4-methoxyphenyl)-2-oxo-2H-1,3,4-thiadiazin-3-ylmethyl)phenyl]-3-(N,N-diisopropylamino)propionamide;

[1591] N-[4-(3,6-dihydro-5-(3-isopropoxy-4-methoxyphenyl)-2-oxo-2H-1,3,4-thiadiazin-3-ylmethyl)phenyl]-3-thiomorpholinopropionamide;

[1592] N-[4-(3,6-dihydro-5-(3-isopropoxy-4-methoxyphenyl)-2-oxo-2H-1,3,4-thiadiazin-3-ylmethyl)phenyl]-3-piperidinopropionamide;

[1593] N-[4-(3,6-dihydro-5-(3-isopropoxy-4-methoxyphenyl)-2-oxo-2H-1,3,4-thiadiazin-3-ylmethyl)phenyl]-3-(4-hydroxypiperidino)propionamide;

[1594] N-[4-(3,6-dihydro-5-(3-isopropoxy-4-methoxyphenyl)-2-oxo-2H-1,3,4-thiadiazin-3-ylmethyl)phenyl]-3-piperazinopropionamide;

[1595] N-[4-(3,6-dihydro-5-(3-isopropoxy-4-methoxyphenyl)-2-oxo-2H-1,3,4-thiadiazin-3-ylmethyl)phenyl]-3-pyrrolidinopropionamide;

[1596] N-[4-(3,6-dihydro-5-(3-cyclopentyloxy-4-methoxyphenyl)-2-oxo-2H-1,3,4-thiadiazin-3-ylmethyl)phenyl]-3-(4-morpholinyl)propionamide;

[1597] N-[4-(3,6-dihydro-5-(3-cyclopentyloxy-4-methoxyphenyl)-2-oxo-2H-1,3,4-thiadiazin-3-ylmethyl)phenyl]-3-(N,N-diethylamino)propionamide;

[1598] N-[4-(3,6-dihydro-5-(3-cyclopentyloxy-4-methoxyphenyl)-2-oxo-2H-1,3,4-thiadiazin-3-ylmethyl)phenyl]-3-(N,N-diisopropylamino)propionamide;

[1599] N-[4-(3,6-dihydro-5-(3-cyclopentyloxy-4-methoxyphenyl)-2-oxo-2H-1,3,4-thiadiazin-3-ylmethyl)phenyl]-3-thiomorpholinopropionamide;

[1600] N-[4-(3,6-dihydro-5-(3-cyclopentyloxy-4-methoxyphenyl)-2-oxo-2H-1,3,4-thiadiazin-3-ylmethyl)phenyl]-3-piperidinopropionamide;

[1601] N-[4-(3,6-dihydro-5-(3-cyclopentyloxy-4-methoxyphenyl)-2-oxo-2H-1,3,4-thiadiazin-3-ylmethyl)phenyl]-3-(4-hydroxypiperidino)propionamide;

[1602] N-[4-(3,6-dihydro-5-(3-cyclopentyloxy-4-methoxyphenyl)-2-oxo-2H-1,3,4-thiadiazin-3-ylmethyl)phenyl]-3-piperazinopropionamide;

[1603] N-[4-(3,6-dihydro-5-(3-cyclopentyloxy-4-methoxyphenyl)-2-oxo-2H-1,3,4-thiadiazin-3-ylmethyl)phenyl]-3-pyrrolidinopropionamide;

[1604] 3-(N,N-diethylamino)propyl N-[4-(6-(3,4-dimethoxyphenyl)-3-oxo-2,3,4,5-tetrahydropyridazin-2-ylmethyl)phenyl]carbamate;

[1605] 3-(N,N-diethylamino)propyl N-[4-(6-(3,4-dimethoxyphenyl)-3-oxo-2,3,4,5-tetrahydropyridazin-2-ylmethyl)phenyl]carbamate;

[1606] 3-(N,N-diisopropylamino)ethyl N-[4-(6-(3,4-dimethoxyphenyl)-3-oxo-2,3,4,5-tetrahydropyridazin-2-ylmethyl)phenyl]carbamate;

[1607] 6-(N,N-dimethylamino)hexyl N-[4-(6-(3,4-dimethoxyphenyl)-3-oxo-2,3,4,5-tetrahydropyridazin-2-ylmethyl)phenyl]carbamate;

[1608] 2-(N,N-dimethylamino)-1-methylethyl N-[4-(6-(3,4-dimethoxyphenyl)-3-oxo-2,3,4,5-tetrahydropyridazin-2-ylmethyl)phenyl]carbamate;

[1609] 1-methyl-4-piperidyl N-[4-(6-(3,4-dimethoxyphenyl)-3-oxo-2,3,4,5-tetrahydropyridazin-2-ylmethyl)phenyl]carbamate;

[1610] (4-hydroxy-1-piperidyl)ethyl N-[4-(6-(3,4-dimethoxyphenyl)-3-oxo-2,3,4,5-tetrahydropyridazin-2-ylmethyl)phenyl]carbamate;

[1611] 2-morpholinoethyl N-[4-(6-(3,4-dimethoxyphenyl)-3-oxo-2,3,4,5-tetrahydropyridazin-2-ylmethyl)phenyl]carbamate;

[1612] 3-morpholinopropyl N-[4-(6-(3,4-dimethoxyphenyl)-3-oxo-2,3,4,5-tetrahydropyridazin-2-ylmethyl)phenyl]carbamate;

[1613] 2-thiomorpholinoethyl N-[4-(6-(3,4-dimethoxyphenyl)-3-oxo-2,3,4,5-tetrahydropyridazin-2-ylmethyl)phenyl]carbamate;

[1614] 3-thiomorpholinopropyl N-[4-(6-(3,4-dimethoxyphenyl)-3-oxo-2,3,4,5-tetrahydropyridazin-2-ylmethyl)phenyl]carbamate;

[1615] 2-piperazinoethyl N-[4-(6-(3,4-dimethoxyphenyl)-3-oxo-2,3,4,5-tetrahydropyridazin-2-ylmethyl)phenyl]carbamate;

[1616] 3-piperazinopropyl N-[4-(6-(3,4-dimethoxyphenyl)-3-oxo-2,3,4,5-tetrahydropyridazin-2-ylmethyl)phenyl]carbamate;

[1617] 2-pyrrolidinoethyl N-[4-(6-(3,4-dimethoxyphenyl)-3-oxo-2,3,4,5-tetrahydropyridazin-2-ylmethyl)phenyl]carbamate;

[1618] 3-pyrrolidinopropyl N-[4-(6-(3,4-dimethoxyphenyl)-3-oxo-2,3,4,5-tetrahydropyridazin-2-ylmethyl)phenyl]carbamate;

[1619] 3-(N,N-diethylamino)propyl N-[4-(6-(3-ethoxy-4-methoxyphenyl)-3-oxo-2,3,4,5-tetrahydropyridazin-2-ylmethyl)phenyl]carbamate;

[1620] 2-(N,N-diethylamino)ethyl N-[4-(6-(3-ethoxy-4-methoxyphenyl)-3-oxo-2,3,4,5-tetrahydropyridazin-2-ylmethyl)phenyl]carbamate;

[1621] 2-(N,N-diisopropylamino)ethyl N-[4-(6-(3-ethoxy-4-methoxyphenyl)-3-oxo-2,3,4,5-tetrahydropyridazin-2-ylmethyl)phenyl]carbamate;

[1622] 6-(N,N-dimethylamino)hexyl N-[4-(6-(3-ethoxy-4-methoxyphenyl)-3-oxo-2,3,4,5-tetrahydropyridazin-2-ylmethyl)phenyl]carbamate;

[1623] 2-(N,N-dimethylamino)-1-methylethyl N-[4-(6-(3-ethoxy-4-methoxyphenyl)-3-oxo-2,3,4,5-tetrahydropyridazin-2-ylmethyl)phenyl]carbamate;

[1624] 1-methyl-4-piperidyl N-[4-(6-(3-ethoxy-4-methoxyphenyl)-3-oxo-2,3,4,5-tetrahydropyridazin-2-ylmethyl)phenyl]carbamate;

[1625] 2-morpholinoethyl N-[4-(6-(3-ethoxy-4-methoxyphenyl)-3-oxo-2,3,4,5-tetrahydropyridazin-2-ylmethyl)phenyl]carbamate;

[1626] 3-morpholinopropyl N-[4-(6-(3-ethoxy-4-methoxyphenyl)-3-oxo-2,3,4,5-tetrahydropyridazin-2-ylmethyl)phenyl]carbamate;

[1627] 2-thiomorpholinoethyl N-[4-(6-(3-ethoxy-4-methoxyphenyl)-3-oxo-2,3,4,5-tetrahydropyridazin-2-ylmethyl)phenyl]carbamate;

[1628] 3-thiomorpholinopropyl N-[4-(6-(3-ethoxy-4-methoxyphenyl)-3-oxo-2,3,4,5-tetrahydropyridazin-2-ylmethyl)phenyl]carbamate;

[1629] 2-piperazinoethyl N-[4-(6-(3-ethoxy-4-methoxyphenyl)-3-oxo-2,3,4,5-tetrahydropyridazin-2-ylmethyl)phenyl]carbamate;

[1630] 3-piperazinopropyl N-[4-(6-(3-ethoxy-4-methoxyphenyl)-3-oxo-2,3,4,5-tetrahydropyridazin-2-ylmethyl)phenyl]carbamate;

[1631] 2-pyrrolidinoethyl N-[4-(6-(3-ethoxy-4-methoxyphenyl)-3-oxo-2,3,4,5-tetrahydropyridazin-2-ylmethyl)phenyl]carbamate;

[1632] 3-pyrrolidinopropyl N-[4-(6-(3-ethoxy-4-methoxyphenyl)-3-oxo-2,3,4,5-tetrahydropyridazin-2-ylmethyl)phenyl]carbamate.

[1633] 3-(N,N-diethylamino)propyl N-[4-(6-(3,4-dimethoxyphenyl)-3-oxo-5-ethyl-2,3,4,5-tetrahydropyridazin-2-ylmethyl)phenyl]carbamate;

[1634] 2-(N,N-diethylamino)ethyl N-[4-(6-(3,4-dimethoxyphenyl)-3-oxo-5-ethyl-2,3,4,5-tetrahydropyridazin-2-ylmethyl)phenyl]carbamate;

[1635] 2-(N,N-diisopropylamino)ethyl N-[4-(6-(3,4-dimethoxyphenyl)-3-oxo-5-ethyl-2,3,4,5-tetrahydropyridazin-2-ylmethyl)phenyl]carbamate;

[1636] 6-(N,N-dimethylamino)hexyl N-[4-(6-(3,4-dimethoxyphenyl)-3-oxo-5-ethyl-2,3,4,5-tetrahydropyridazin-2-ylmethyl)phenyl]carbamate;

[1637] 2-(N,N-dimethylamino)-1-methylethyl N-[4-(6-(3,4-dimethoxyphenyl)-3-oxo-5-ethyl-2,3,4,5-tetrahydropyridazin-2-ylmethyl)phenyl]carbamate;

[1638] 1-methyl-4-piperidylN-[4-(5-(3,4-dimethoxyphenyl)-3-oxo-5-ethyl-2,3,4,5-tetrahydropyridazin-2-ylmethyl)phenyl]carbamate;

[1639] 2-morpholinoethyl N-[4-(6-(3,4-dimethoxyphenyl)-3-oxo-5-ethyl-2,3,4,5-tetrahydropyridazin-2-ylmethyl)phenyl]carbamate;

[1640] 3-morpholinopropylN-[4-(6-(3,4-dimethoxyphenyl)-3-oxo-5-ethyl-2,3,4,5-tetrahydropyridazin-2-ylmethyl)phenyl]carbamate;

[1641] 2-thiomorpholinoethyl N-[4-(6-(3,4-dimethoxyphenyl)-3-oxo-5-ethyl-2,3,4,5-tetrahydropyridazin-2-ylmethyl)phenyl]carbamate;

[1642] 3-thiomorpholinopropyl N-[4-(6-(3,4-dimethoxyphenyl)-3-oxo-5-ethyl-2,3,4,5-tetrahydropyridazin-2-ylmethyl)phenyl]carbamate;

[1643] 2-piperazinoethyl N-[4-(6-(3,4-dimethoxyphenyl)-3-oxo-5-ethyl-2,3,4,5-tetrahydropyridazin-2-ylmethyl)phenyl]carbamate;

[1644] 3-piperazinopropyl N-[4-(6-(3,4-dimethoxyphenyl)-3-oxo-5-ethyl-2,3,4,5-tetrahydropyridazin-2-ylmethyl)phenyl]carbamate;

[1645] 2-pyrrolidinoethyl N-[4-(6-(3,4-dimethoxyphenyl)-3-oxo-5-ethyl-2,3,4,5-tetrahydropyridazin-2-ylmethyl)phenyl]carbamate;

[1646] 3-pyrrolidinopropyl N-[4-(6-(3,4-dimethoxyphenyl)-3-oxo-5-ethyl-2,3,4,5-tetrahydropyridazin-2-ylmethyl)phenyl]carbamate;

[1647] 3-(N,N-diethylamino)propyl N-[4-(6-(3-ethoxy-4-methoxyphenyl)-3-oxo-5-ethyl-2,3,4,5-tetrahydropyridazin-2-ylmethyl)phenyl]carbamate;

[1648] 2-(N,N-diethylamino)ethyl N-[4-(6-(3-ethoxy-4-methoxyphenyl)-3-oxo-5-ethyl-2,3,4,5-tetrahydropyridazin-2-ylmethyl)phenyl]carbamate;

[1649] 2-(N,N-diisopropylamino)ethyl N-[4-(6-(3-ethoxy-4-methoxyphenyl)-3-oxo-5-ethyl-2,3,4,5-tetrahydropyridazin-2-ylmethyl)phenyl]carbamate;

[1650] 6-(N,N-dimethylamino)hexyl N-[4-(6-(3-ethoxy-4-methoxyphenyl)-3-oxo-5-ethyl-2,3,4,5-tetrahydropyridazin-2-ylmethyl)phenyl]carbamate;

[1651] 2-(N,N-dimethylamino)-1-methylethyl N-[4-(6-(3-ethoxy-4-methoxyphenyl)-3-oxo-5-ethyl-2,3,4,5-tetrahydropyridazin-2-ylmethyl)phenyl]carbamate;

[1652] 1-methyl-4-piperidyl N-[4-(6-(3-ethoxy-4-methoxyphenyl)-3-oxo-5-ethyl-2,3,4,5-tetrahydropyridazin-2-ylmethyl)phenyl]carbamate;

[1653] 2-morpholinoethyl N-[4-(6-(3-ethoxy-4-methoxyphenyl)-3-oxo-5-ethyl-2,3,4,5-tetrahydropyridazin-2-ylmethyl)phenyl]carbamate;

[1654] 3-morpholinopropyl N-[4-(6-(3-ethoxy-4-methoxyphenyl)-3-oxo-5-ethyl-2,3,4,5-tetrahydropyridazin-2-ylmethyl)phenyl]carbamate;

[1655] 2-thiomorpholinoethylN-[4-(6-(3-ethoxy-4-methoxyphenyl)-3-oxo-5-ethyl-2,3,4,5-tetrahydropyridazin-2-ylmethyl)phenyl]carbamate;

[1656] 3-thiomorpholinopropylN-[4-(6-(3-ethoxy-4-methoxyphenyl)-3-oxo-5-ethyl-2,3,4,5-tetrahydropyridazin-2-ylmethyl)phenyl]carbamate;

[1657] 2-piperazinoethyl N-[4-(6-(3-ethoxy-4-methoxyphenyl)-3-oxo-5-ethyl-2,3,4,5-tetrahydropyridazin-2-ylmethyl)phenyl]carbamate;

[1658] 3-piperazinopropyl N-[4-(6-(3-ethoxy-4-methoxyphenyl)-3-oxo-5-ethyl-2,3,4,5-tetrahydropyridazin-2-ylmethyl)phenyl]carbamate;

[1659] 2-pyrrolidinoethyl N-[4-(6-(3-ethoxy-4-methoxyphenyl)-3-oxo-5-ethyl-2,3,4,5-tetrahydropyridazin-2-ylmethyl)phenyl]carbamate;

[1660] 3-pyrrolidinopropyl N-[4-(6-(3-ethoxy-4-methoxyphenyl)-3-oxo-5-ethyl-2,3,4,5-tetrahydropyridazin-2-ylmethyl)phenyl]carbamate;

[1661] 3-(N,N-diethylamino)propyl N-[4-(6-(3-cyclopentyloxy-4-methoxyphenyl)-3-oxo-2,3,4,5-tetrahydropyridazin-2-ylmethyl)phenyl]carbamate;

[1662] 2-(N,N-diethylamino)ethyl N-[4-(6-(3-cyclopentyloxy-4-methoxyphenyl)-3-oxo-2,3,4,5-tetrahydropyridazin-2-ylmethyl)phenyl]carbamate;

[1663] 2-(N,N-diisopropylamino)ethyl N-[4-(6-(3-cyclopentyloxy-4-methoxyphenyl)-3-oxo-2,3,4,5-tetrahydropyridazin-2-ylmethyl)phenyl]carbamate;

[1664] 6-(N,N-dimethylamino)hexyl N-[4-(6-(3-cyclopentyloxy-4-methoxyphenyl)-3-oxo-2,3,4,5-tetrahydropyridazin-2-ylmethyl)phenyl]carbamate;

[1665] 2-(N,N-dimethylamino)-1-methylethyl N-[4-(6-(3-cyclopentyloxy-4-methoxyphenyl)-3-oxo-2,3,4,5-tetrahydropyridazin-2-ylmethyl)phenyl]carbamate;

[1666] 1-methyl-4-piperidylN-[4-(6-(3-cyclopentyloxy-4-methoxyphenyl)-3-oxo-2,3,4,5-tetrahydropyridazin-2-ylmethyl)phenyl]carbamate;

[1667] 2-morpholinoethyl N-[4-(6-(3-cyclopentyloxy-4-methoxyphenyl)-3-oxo-2,3,4,5-tetrahydropyridazin-2-ylmethyl)phenyl]carbamate;

[1668] 3-morpholinopropyl N-[4-(6-(3-cyclopentyloxy-4-methoxyphenyl)-3-oxo-2,3,4,5-tetrahydropyridazin-2-ylmethyl)phenyl]carbamate;

[1669] 2-thiomorpholinoethyl N-[4-(6-(3-cyclopentyloxy-4-methoxyphenyl)-3-oxo-2,3,4,5-tetrahydropyridazin-2-ylmethyl)phenyl]carbamate;

[1670] 3-thiomorpholinopropyl N-[4-(6-(3-cyclopentyloxy-4-methoxyphenyl)-3-oxo-2,3,4,5-tetrahydropyridazin-2-ylmethyl)phenyl]carbamate;

[1671] 2-piperazinoethyl N-[4-(6-(3-cyclopentyloxy-4-methoxyphenyl)-3-oxo-2,3,4,5-tetrahydropyridazin-2-ylmethyl)phenyl]carbamate;

[1672] 3-piperazinopropyl N-[4-(6-(3-cyclopentyloxy-4-methoxyphenyl)-3-oxo-2,3,4,5-tetrahydropyridazin-2-ylmethyl)phenyl]carbamate;

[1673] 2-pyrrolidinoethyl N-[4-(6-(3-cyclopentyloxy-4-methoxyphenyl)-3-oxo-2,3,4,5-tetrahydropyridazin-2-ylmethyl)phenyl]carbamate;

[1674] 3-pyrrolidinopropyl N-[4-(6-(3-cyclopentyloxy-4-methoxyphenyl)-3-oxo-2,3,4,5-tetrahydropyridazin-2-ylmethyl)phenyl]carbamate;

[1675] 3-(N,N-diethylamino)propyl N-[4-(6-(3-propoxy-4-methoxyphenyl)-3-oxo-2,3,4,5-tetrahydropyridazin-2-ylmethyl)phenyl]carbamate;

[1676] 2-(N,N-diethylamino)ethyl N-[4-(6-(3-propoxy-4-methoxyphenyl)-3-oxo-2,3,4,5-tetrahydropyridazin-2-ylmethyl)phenyl]carbamate;

[1677] 2-(N,N-diisopropylamino)ethyl N-[4-(6-(3-propoxy-4-methoxyphenyl)-3-oxo-2,3,4,5-tetrahydropyridazin-2-ylmethyl)phenyl]carbamate;

[1678] 6-(N,N-dimethylamino)hexyl N-[4-(6-(3-propoxy-4-methoxyphenyl)-3-oxo-2,3,4,5-tetrahydropyridazin-2-ylmethyl)phenyl]carbamate;

[1679] 2-(N,N-dimethylamino)-1-methylethyl N-[4-(6-(3-propoxy-4-methoxyphenyl)-3-oxo-2,3,4,5-tetrahydropyridazin-2-ylmethyl)phenyl]carbamate;

[1680] 1-methyl-4-piperidyl N-[4-(6-(3-propoxy-4-methoxyphenyl)-3-oxo-2,3,4,5-tetrahydropyridazin-2-ylmethyl)phenyl]carbamate;

[1681] 2-morpholinoethyl N-[4-(6-(3-propoxy-4-methoxyphenyl)-3-oxo-2,3,4,5-tetrahydropyridazin-2-ylmethyl)phenyl]carbamate;

[1682] 3-morpholinopropyl N-[4-(6-(3-propoxy-4-methoxyphenyl)-3-oxo-2,3,4,5-tetrahydropyridazin-2-ylmethyl)phenyl]carbamate;

[1683] 2-thiomorpholinoethyl N-[4-(6-(3-propoxy-4-methoxyphenyl)-3-oxo-2,3,4,5-tetrahydropyridazin-2-ylmethyl)phenyl]carbamate;

[1684] 3-thiomorpholinopropyl N-[4-(6-(3-propoxy-4-methoxyphenyl)-3-oxo-2,3,4,5-tetrahydropyridazin-2-ylmethyl)phenyl]carbamate;

[1685] 2-piperazinoethyl N-[4-(6-(3-propoxy-4-methoxyphenyl)-3-oxo-2,3,4,5-tetrahydropyridazin-2-ylmethyl)phenyl]carbamate;

[1686] 3-piperazinopropyl N-[4-(6-(3-propoxy-4-methoxyphenyl)-3-oxo-2,3,4,5-tetrahydropyridazin-2-ylmethyl)phenyl]carbamate;

[1687] 2-pyrrolidinoethyl N-[4-(6-(3-propoxy-4-methoxyphenyl)-3-oxo-2,3,4,5-tetrahydropyridazin-2-ylmethyl)phenyl]carbamate;

[1688] 3-pyrrolidinopropyl N-[4-(6-(3-propoxy-4-methoxyphenyl)-3-oxo-2,3,4,5-tetrahydropyridazin-2-ylmethyl)phenyl]carbamate;

[1689] 3-(N,N-diethylamino)propyl N-[4-(6-(3-isopropoxy-4-methoxyphenyl)-3-oxo-2,3,4,5-tetrahydropyridazin-2-ylmethyl)phenyl]carbamate;

[1690] 2-(N,N-diethylamino)ethyl N-[4-(6-(3-isopropoxy-4-methoxyphenyl)-3-oxo-2,3,4,5-tetrahydropyridazin-2-ylmethyl)phenyl]carbamate;

[1691] 2-(N,N-diisopropylamino)ethyl N-[4-(6-(3-isopropoxy-4-methoxyphenyl)-3-oxo-2,3,4,5-tetrahydropyridazin-2-ylmethyl)phenyl]carbamate;

[1692] 6-(N,N-dimethylamino)hexyl N-[4-(6-(3-isopropoxy-4-methoxyphenyl)-3-oxo-2,3,4,5-tetrahydropyridazin-2-ylmethyl)phenyl]carbamate;

[1693] 2-(N,N-dimethylamino)-1-methylethyl N-[4-(6-(3-isopropoxy-4-methoxyphenyl)-3-oxo-2,3,4,5-tetrahydropyridazin-2-ylmethyl)phenyl]carbamate;

[1694] 1-methyl-4-piperidyl N-[4-(6-(3-isopropoxy-4-methoxyphenyl)-3oxo-2,3,4,5-tetrahydropyridazin-2-ylmethyl)phenyl]carbamate;

[1695] 2-morpholinoethyl N-[4-(6-(3-isopropoxy-4-methoxyphenyl)-3-oxo-2,3,4,5-tetrahydropyridazin-2-ylmethyl)phenyl]carbamate;

[1696] 3-morpholinopropyl N-[4-(6-(3-isopropoxy-4-methoxyphenyl)-3-oxo-2,3,4,5-tetrahydropyridazin-2-ylmethyl)phenyl]carbamate;

[1697] 2-thiomorpholinoethyl N-[4-(6-(3-isopropoxy-4-methoxyphenyl)-3-oxo-2,3,4,5-tetrahydropyridazin-2-ylmethyl)phenyl)carbamate;

[1698] 3-thiomorpholinopropyl N-[4-(6-(3-isopropoxy-4-methoxyphenyl)-3-oxo-2,3,4,5-tetrahydropyridazin-2-ylmethyl)phenyl]carbamate;

[1699] 2-piperazinoethyl N-[4-(6-(3-isopropoxy-4-methoxyphenyl)-3-oxo-2,3,4,5-tetrahydropyridazin-2-ylmethyl)phenyl]carbamate;

[1700] 3-piperazinopropyl N-[4-(6-(3-isopropoxy-4-methoxyphenyl)-3-oxo-2,3,4,5-tetrahydropyridazin-2-ylmethyl)phenyl]carbamate;

[1701] 2-pyrrolidinoethyl N-[4-(6-(3-isopropoxy-4-methoxyphenyl)-3-oxo-2,3,4,5-tetrahydropyridazin-2-ylmethyl)phenyl]carbamate;

[1702] 3-pyrrolidinopropyl N-[4-(6-(3-isopropoxy-4-methoxyphenyl)-3-oxo-2,3,4,5-tetrahydropyridazin-2-ylmethyl)phenyl]carbamate;

[1703] 3-(N,N-diethylamino)propyl N-[4-(6-(3-fluoromethoxy-4-methoxyphenyl)-3-oxo-2,3,4,5-tetrahydropyridazin-2-ylmethyl)phenyl]carbamate;

[1704] 2-(N,N-diethylamino)ethyl N-[4-(6-(3-fluoromethoxy-4-methoxyphenyl)-3-oxo-2,3,4,5-tetrahydropyridazin-2-ylmethyl)phenyl]carbamate;

[1705] 2-(N,N-diisopropylamino)ethyl N-[4-(6-(3-fluoromethoxy-4-methoxyphenyl)-3-oxo-2,3,4,5-tetrahydropyridazin-2-ylmethyl)phenyl]carbamate;

[1706] 6-(N,N-dimethylamino)hexyl N-[4-(6-(3-fluoromethoxy-4-methoxyphenyl)-3-oxo-2,3,4,5-tetrahydropyridazin-2-ylmethyl)phenyl]carbamate;

[1707] 2-(N,N-dimethylamino)-1-methylethyl N-[4-(6-(3-fluoromethoxy-4-methoxyphenyl)-3-oxo-2,3,4,5-tetrahydropyridazin-2-ylmethyl)phenyl]carbamate;

[1708] 1-methyl-4-piperidyl N-[4-(6-(3-fluoromethoxy-4-methoxyphenyl)-3-oxo-2,3,4,5-tetrahydropyridazin-2-ylmethyl)phenyl]carbamate;

[1709] 2-morpholinoethyl N-[4-(6-(3-fluoromethoxy-4-methoxyphenyl)-3-oxo-2,3,4,5-tetrahydropyridazin-2-ylmethyl)phenyl]carbamate;

[1710] 3-morpholinopropyl N-[4-(6-(3-fluoromethoxy-4-methoxyphenyl)-3-oxo-2,3,4,5-tetrahydropyridazin-2-ylmethyl)phenyl]carbamate;

[1711] 2-thiomorpholinoethyl N-[4-(6-(3-fluoromethoxy-4-methoxyphenyl)-3-oxo-2,3,4,5-tetrahydropyridazin-2-ylmethyl)phenyl]carbamate;

[1712] 3-thiomorpholinopropyl N-[4-(6-(3-fluoromethoxy-4-methoxyphenyl)-3-oxo-2,3,4,5-tetrahydropyridazin-2-ylmethyl)phenyl]carbamate;

[1713] 2-piperazinoethyl N-[4-(6-(3-fluoromethoxy-4-methoxyphenyl)-3-oxo-2,3,4,5-tetrahydropyridazin-2-ylmethyl)phenyl]carbamate;

[1714] 3-piperazinopropyl N-[4-(6-(3-fluoromethoxy-4-methoxyphenyl)-3-oxo-2,3,4,5-tetrahydropyridazin-2-ylmethyl)phenyl]carbamate;

[1715] 2-pyrrolidinoethyl N-[4-(6-(3-fluoromethoxy-4-methoxyphenyl)-3-oxo-2,3,4,5-tetrahydropyridazin-2-ylmethyl)phenyl]carbamate;

[1716] 3-pyrrolidinopropyl N-(8 4-(6-(3-fluoromethoxy-4-methoxyphenyl)-3-oxo-2,3,4,5-tetrahydropyridazin-2-ylmethyl)phenyl]carbamate.

[1717] N-[4-(6-(3-ethoxy-4-methoxyphenyl)-3-oxo-2,3,4,5-tetrahydropyridazin-2-ylmethyl)phenyl]-2-(4-morpholinyl)acetamide, m.p. 150°;

[1718] N-[4-(6-(3-ethoxy-4-methoxyphenyl)-3-oxo-2,3,4,5-tetrahydropyridazin-2-ylmethyl)phenyl]-2-(N,N-diethylamino)acetamide;

[1719] N-[4-(6-(3-ethoxy-4-methoxyphenyl)-3-oxo-2,3,4,5-tetrahydropyridazin-2-ylmethyl)phenyl]-2-(N,N-diisopropylamino)acetamide;

[1720] N-[4-(6-(3-ethoxy-4-methoxyphenyl)-3-oxo-2,3,4,5-tetrahydropyridazin-2-ylmethyl)phenyl]-2-thiomorpholinoacetamide;

[1721] N-[4-(6-(3-ethoxy-4-methoxyphenyl)-3-oxo-2,3,4,5-tetrahydropyridazin-2-ylmethyl)phenyl]-2-piperidinoacetamide;

[1722] N-[4-(6-(3-ethoxy-4-methoxyphenyl)-3-oxo-2,3,4,5-tetrahydropyridazin-2-ylmethyl)phenyl]-2-(4-hydroxypiperidino)acetamide;

[1723] N-[4-(6-(3-ethoxy-4-methoxyphenyl)-3-oxo-2,3,4,5-tetrahydropyridazin-2-ylmethyl)phenyl]-2-piperazinoacetamide;

[1724] N-[4-(6-(3-ethoxy-4-methoxyphenyl)-3-oxo-2,3,4,5-tetrahydropyridazin-2-ylmethyl)phenyl]-2-pyrrolidinoacetamide;

[1725] N-[4-(6-(3,4-dimethoxyphenyl)-3-oxo-2,3,4,5-tetrahydropyridazin-2-ylmethyl)phenyl]-2-(4-morpholinyl)acetamide;

[1726] N-[4-(6-(3,4-dimethoxyphenyl)-3-oxo-2,3,4,5-tetrahydropyridazin-2-ylmethyl)phenyl]-2-(N,N-diethylamino)acetamide;

[1727] N-[4-(6-(3,4-dimethoxyphenyl)-3-oxo-2,3,4,5-tetrahydropyridazin-2-ylmethyl)phenyl]-2-(N,N-diisopropylamino)acetamide;

[1728] N-[4-(6-(3,4-dimethoxyphenyl)-3-oxo-2,3,4,5-tetrahydropyridazin-2-ylmethyl)phenyl]-2-thiomorpholinoacetamide;

[1729] N-[4-(6-(3,4-dimethoxyphenyl)-3-oxo-2,3,4,5-tetrahydropyridazin-2-ylmethyl)phenyl]-2-piperidinoacetamide;

[1730] N-[4-(6-(3,4-dimethoxyphenyl)-3-oxo-2,3,4,5-tetrahydropyridazin-2-ylmethyl)phenyl]-2-(4-hydroxypiperidino)acetamide;

[1731] N-[4-(6-(3,4-dimethoxyphenyl)-3-oxo-2,3,4,5-tetrahydropyridazin-2-ylmethyl)phenyl]-2-piperazinoacetamide;

[1732] N-[4-(6-(3,4-dimethoxyphenyl)-3-oxo-2,3,4,5-tetrahydropyridazin-2-ylmethyl)phenyl]-2-pyrrolidinoacetamide;

[1733] N-[4-(6-(3,4-dimethoxyphenyl)-3-oxo-2,3,4,5-tetrahydropyridazin-2-ylmethyl)phenyl]-3-(4-morpholinyl)propionamide;

[1734] N-[4-(6-(3,4-dimethoxyphenyl)-3-oxo-2,3,4,5-tetrahydropyridazin-2-ylmethyl)phenyl]-3-(N,N-diethylamino)propionamide;

[1735] N-[4-(6-(3,4-dimethoxyphenyl)-3-oxo-2,3,4,5-tetrahydropyridazin-2-ylmethyl)phenyl]-3-(N,N-diisopropylamino)propionamide;

[1736] N-[4-(6-(3,4-dimethoxyphenyl)-3-oxo-2,3,4,5-tetrahydropyridazin-2-ylmethyl)phenyl]-3-thiomorpholinopropionamide;

[1737] N-[4-(3,4-dimethoxyphenyl)-3-oxo-2,3,4,5-tetrahydropyridazin-2-ylmethyl)phenyl]-3-piperidinopropionamide;

[1738] N-[4-(6-(3,4-dimethoxyphenyl)-3-oxo-2,3,4,5-tetrahydropyridazin-2-ylmethyl)phenyl]-3-(4-hydroxypiperidino)propionamide;

[1739] N-[4-(6-(3,4-dimethoxyphenyl)-3-oxo-2,3,4,5-tetrahydropyridazin-2-ylmethyl)phenyl]-3-piperazinopropionamide;

[1740] N-[4-(6-(3,4-dimethoxyphenyl)-3-oxo-2,3,4,5-tetrahydropyridazin-2-ylmethyl)phenyl]-3-pyrrolidinopropionamide;

[1741] N-[4-(6-(3-propoxy-4-methoxyphenyl)-3-oxo-2,3,4,5-tetrahydropyridazin-2-ylmethyl)phenyl]-2-(4-morpholinyl)acetamide;

[1742] N-[4-(6-(3-propoxy-4-methoxyphenyl)-3-oxo-2,3,4,5-tetrahydropyridazin-2-ylmethyl)phenyl]-2-(N,N-diethylamino)acetamide;

[1743] N-[4-(6-(3-propoxy-4-methoxyphenyl)-3-oxo-2,3,4,5-tetrahydropyridazin-2-ylmethyl)phenyl]-2-(N,N-diisopropylamino)acetamide;

[1744] N-[4-(6-(3-propoxy-4-methoxyphenyl)-3-oxo-2,3,4,5-tetrahydropyridazin-2-ylmethyl)phenyl]-2-thiomorpholinoacetamide;

[1745] N-[4-(6-(3-propoxy-4-methoxyphenyl)-3-oxo-2,3,4,5-tetrahydropyridazin-2-ylmethyl)phenyl]-2-piperidinoacetamide;

[1746] N-[4-(6-(3-propoxy-4-methoxyphenyl)-3-oxo-2,3,4,5-tetrahydropyridazin-2-ylmethyl)phenyl]-2-(4-hydroxypiperidino)acetamide;

[1747] N-[4-(6-(3-propoxy-4-methoxyphenyl)-3-oxo-2,3,4,5-tetrahydropyridazin-2-ylmethyl)-2-piperazinoacetamide;

[1748] N-[4-(6-(3-propoxy-4-methoxyphenyl)-3-oxo-2,3,4,5-tetrahydropyridazin-2-ylmethyl)phenyl]-2-pyrrolidinoacetamide;

[1749] N-[4-(6-(3-isopropoxy-4-methoxyphenyl)-3-oxo-2,3,4,5-tetrahydropyridazin-2-ylmethyl)phenyl]-2-(4-morpholinyl)acetamide;

[1750] N-[4-(6-(3-isopropoxy-4-methoxyphenyl)-3-oxo-2,3,4,5-tetrahydropyridazin-2-ylmethyl)phenyl]-2-(N,N-diethylamino)acetamide;

[1751] N-[4-(6-(3-isopropoxy-4-methoxyphenyl)-3-oxo-2,3,4,5-tetrahydropyridazin-2-ylmethyl)phenyl]-2-(N,N-diisopropylamino)acetamide;

[1752] N-[4-(6-(3-isopropoxy-4-methoxyphenyl)-3-oxo-2,3,4,5-tetrahydropyridazin-2-ylmethyl)phenyl]-2-thiomorpholinoacetamide;

[1753] N-[4-(6-(3-isopropoxy-4-methoxyphenyl)-3-oxo-2,3,4,5-tetrahydropyridazin-2-ylmethyl)phenyl]-2-piperidinoacetamide;

[1754] N-[4-(6-(3-isopropoxy-4-methoxyphenyl)-3-oxo-2,3,4,5-tetrahydropyridazin-2-ylmethyl)phenyl]-2-(4-hydroxypiperidino)acetamide;

[1755] N-[4-(6-(3-isopropoxy-4-methoxyphenyl)-3-oxo-2,3,4,5-tetrahydropyridazin-2-ylmethyl)-2-piperazinoacetamide;

[1756] N-[4-(6-(3-isopropoxy-4-methoxyphenyl)-3-oxo-2,3,4,5-tetrahydropyridazin-2-ylmethyl)phenyl]-2-pyrrolidinoacetamide;

[1757] N-[4-(6-(3-cyclopentyloxy-4-methoxyphenyl)-3-oxo-2,3,4,5-tetrahydropyridazin-2-ylmethyl)phenyl]-2-(4-morpholinyl)acetamide;

[1758] N-[4-(6-(3-cyclopentyloxy-4-methoxyphenyl)-3-oxo-2,3,4,5-tetrahydropyridazin-2-ylmethyl)phenyl]-2-(N,N-diethylamino)acetamide;

[1759] N-[4-(6-(3-cyclopentyloxy-4-methoxyphenyl)-3-oxo-2,3,4,5-tetrahydropyridazin-2-ylmethyl)phenyl]-2-(N,N-diisopropylamino)acetamide;

[1760] N-[4-(6-(3-cyclopentyloxy-4-methoxyphenyl)-3-oxo-2,3,4,5-tetrahydropyridazin-2-ylmethyl)phenyl]-2-thiomorpholinoacetamide;

[1761] N-[4-(6-(3-cyclopentyloxy-4-methoxyphenyl)-3-oxo-2,3,4,5-tetrahydropyridazin-2-ylmethyl)phenyl]-2-piperidinoacetamide;

[1762] N-[4-(6-(3-cyclopentyloxy-4-methoxyphenyl)-3-oxo-2,3,4,5-tetrahydropyridazin-2-ylmethyl)phenyl]-2-(4-hydroxypiperidino)acetamide;

[1763] N-[4-(6-(3-cyclopentyloxy-4-methoxyphenyl)-3-oxo-2,3,4,5-tetrahydropyridazin-2-ylmethyl)-2-piperazinoacetamide;

[1764] N-[4-(6-(3-cyclopentyloxy-4-methoxyphenyl)-3-oxo-2,3,4,5-tetrahydropyridazin-2-ylmethyl)phenyl]-2-pyrrolidinoacetamide;

[1765] N-[4-(6-(3-ethoxy-4-methoxyphenyl)-3-oxo-2,3,4,5-tetrahydropyridazin-2-ylmethyl)phenyl]-3-(4-morpholinyl)propionamide;

[1766] N-[4-(6-(3-ethoxy-4-methoxyphenyl)-3-oxo-2,3,4,5-tetrahydropyridazin-2-ylmethyl)phenyl]-3-(N,N-diethylamino)propionamide;

[1767] N-[4-(6-(3-ethoxy-4-methoxyphenyl)-3-oxo-2,3,4,5-tetrahydropyridazin-2-ylmethyl)phenyl]-3-(N,N-diisopropylamino)propionamide;

[1768] N-[4-(6-(3-ethoxy-4-methoxyphenyl)-3-oxo-2,3,4,5-tetrahydropyridazin-2-ylmethyl)phenyl]-3-thiomorpholinoacetamide;

[1769] N-[4-(6-(3-ethoxy-4-methoxyphenyl)-3-oxo-2,3,4,5-tetrahydropyridazin-2-ylmethyl)phenyl]-3-piperidinopropionamide;

[1770] N-[4-(6-(3-ethoxy-4-methoxyphenyl)-3-oxo-2,3,4,5-tetrahydropyridazin-2-ylmethyl)phenyl]-3-(4-hydroxypiperidino)propionamide;

[1771] N-[4-(6-(3-ethoxy-4-methoxyphenyl)-3-oxo-2,3,4,5-tetrahydropyridazin-2-ylmethyl)phenyl]-3-piperazinopropionamide;

[1772] N-[4-(6-(3-ethoxy-4-methoxyphenyl)-3-oxo-2,3,4,5-tetrahydropyridazin-2-ylmethyl)phenyl]-3-pyrrolidinopropionamide;

[1773] N-[4-(6-(3-propoxy-4-methoxyphenyl)-3-oxo-2,3,4,5-tetrahydropyridazin-2-ylmethyl)phenyl]-3-(4-morpholinyl)propionamide;

[1774] N-[4-(6-(3-propoxy-4-methoxyphenyl)-3-oxo-2,3,4,5-tetrahydropyridazin-2-ylmethyl)phenyl]-3-(N,N-diethylamino)propionamide;

[1775] N-[4-(6-(3-propoxy-4-methoxyphenyl)-3-oxo-2,3,4,5-tetrahydropyridazin-2-ylmethyl)phenyl]-3-(N,N-diisopropylamino)propionamide;

[1776] N-[4-(6-(3-propoxy-4-methoxyphenyl)-3-oxo-2,3,4,5-tetrahydropyridazin-2-ylmethyl)phenyl]-3-thiomorpholinopropionamide;

[1777] N-[4-(6-(3-propoxy-4-methoxyphenyl)-3-oxo-2,3,4,5-tetrahydropyridazin-2-ylmethyl)phenyl]-3-piperidinopropionamide;

[1778] N-[4-(6-(3-propoxy-4-methoxyphenyl)-3-oxo-2,3,4,5-tetrahydropyridazin-2-ylmethyl)phenyl]-3-(4-hydroxypiperidino)propionamide;

[1779] N-[4-(6-(3-propoxy-4-methoxyphenyl)-3-oxo-2,3,4,5-tetrahydropyridazin-2-ylmethyl)phenyl]-3-piperazinopropionamide;

[1780] N-[4-(6-(3-propoxy-4-methoxyphenyl)-3-oxo-2,3,4,5-tetrahydropyridazin-2-ylmethyl)phenyl]-3-pyrrolidinopropionamide;

[1781] N-[4-(6-(3-isopropoxy-4-methoxyphenyl)-3-oxo-2,3,4,5-tetrahydropyridazin-2-ylmethyl)phenyl]-3-(4-morpholinyl)propionamide;

[1782] N-[4-(6-(3-isopropoxy-4-methoxyphenyl)-3-oxo-2,3,4,5-tetrahydropyridazin-2-ylmethyl)phenyl]-3-(N,N-diethylamino)propionamide;

[1783] N-[4-(6-(3-isopropoxy-4-methoxyphenyl)-3-oxo-2,3,4,5-tetrahydropyridazin-2-ylmethyl)phenyl]-3-(N,N-diisopropylamino)propionamide;

[1784] N-[4-(6-(3-isopropoxy-4-methoxyphenyl)-3-oxo-2,3,4,5-tetrahydropyridazin-2-ylmethyl)phenyl]-3-thiomorpholinopropionamide;

[1785] N-[4-(6-(3-isopropoxy-4-methoxyphenyl)-3-oxo-2,3,4,5-tetrahydropyridazin-2-ylmethyl)phenyl]-3-piperidinopropionamide;

[1786] N-[4-(6-(3-isopropoxy-4-methoxyphenyl)-3-oxo-2,3,4,5-tetrahydropyridazin-2-ylmethyl)phenyl]-3-(4-hydroxypiperidino)propionamide;

[1787] N-[4-(6-(3-isopropoxy-4-methoxyphenyl)-3-oxo-2,3,4,5-tetrahydropyridazin-2-ylmethyl)phenyl]-3-piperazinopropionamide;

[1788] N-[4-(6-(3-isopropoxy-4-methoxyphenyl)-3-oxo-2,3,4,5-tetrahydropyridazin-2-ylmethyl)phenyl]-3-pyrrolidinopropionamide;

[1789] N-[4-(6-(3-cyclopentyloxy-4-methoxyphenyl)-3-oxo-2,3,4,5-tetrahydropyridazin-2-ylmethyl)phenyl]-3-(4-morpholinyl)propionamide;

[1790] N-[4-(6-(3-cyclopentyloxy-4-methoxyphenyl)-3-oxo-2,3,4,5-tetrahydropyridazin-2-ylmethyl)phenyl]-3-(N,N-diethylamino)propionamide;

[1791] N-[4-(6-(3-cyclopentyloxy-4-methoxyphenyl)-3-oxo-2,3,4,5-tetrahydropyridazin-2-ylmethyl)phenyl]-3-(N,N-diisopropylamino)propionamide;

[1792] N-[4-(6-(3-cyclopentyloxy-4-methoxyphenyl)-3-oxo-2,3,4,5-tetrahydropyridazin-2-ylmethyl)phenyl]-3-thiomorpholinopropionamide;

[1793] N-[4-(6-(3-cyclopentyloxy-4-methoxyphenyl)-3-oxo-2,3,4,5-tetrahydropyridazin-2-ylmethyl)phenyl]-3-piperidinopropionamide;

[1794] N-[4-(6-(3-cyclopentyloxy-4-methoxyphenyl)-3-oxo-2,3,4,5-tetrahydropyridazin-2-ylmethyl)phenyl]-3-(4-hydroxypiperidino)propionamide;

[1795] N-[4-(6-(3-cyclopentyloxy-4-methoxyphenyl)-3-oxo-2,3,4,5-tetrahydropyridazin-2-ylmethyl)phenyl]-3-piperazinopropionamide;

[1796] N-[4-(6-(3-cyclopentyloxy-4-methoxyphenyl)-3-oxo-2,3,4,5-tetrahydropyridazin-2-ylmethyl)phenyl]-3-pyrrolidinopropionamide;

[1797] 3-(N,N-diethylamino)propyl N-[4-(3,6-dihydro-5-(3,4-dimethoxyphenyl)-2-oxo-2H-1,3,4-thiadiazin-3-ylmethyl)phenyl]carbamate;

[1798] and/or physiologically acceptable salts thereof for the preparation of a medicament for the treatment of osteoporosis, tumours, tumour metastases, atherosclerosis, rheumatoid arthritis, multiple sclerosis, diabetes mellitus, ulcerative collitis and AIDS.

[1799] The invention relates, in particular, to the use of

[1800] a) compounds, disclosed in EP 0 738 715 A2, selected from the group consisting of

[1801] 2-3-ethoxycarbonylaminobenzyl)-6-(3,4-dimethoxyphenyl)-2,3,4,5-tetrahydropyridazin-3-one;

[1802] 2-3-methylsulfonamidobenzyl)-6-(3,4-dimethoxyphenyl)-2,3,4,5-tetrahydropyridazin-3-one;

[1803] 2-3-acetamidobenzyl)-6-(3,4-dimethoxyphenyl)-2,3,4,5-tetrahydropyridazin-3-one;

[1804] 2-4-trifluoroacetamidobenzyl)-6-(3,4-dimethoxyphenyl)-5-ethyl-2,3,4,5-tetrahydropyridazin-3-one;

[1805] 2-4-ethoxycarbonylaminobenzyl)-6-(3,4-dimethoxyphenyl)-5-ethyl-2,3,4,5-tetrahydropyridazin-3-one;

[1806] 2-(4-methoxycarbonylaminobenzyl)-6-(3,4-dimethoxyphenyl)-5-ethyl-2,3,4,5-tetrahydropyridazin-3-one;

[1807] 2-(4-butyrylaminobenzyl)-6-(3,4-dimethoxyphenyl)-5-ethyl-2,3,4,5-tetrahydropyridazin-3-one;

[1808] b) compounds, disclosed in EP 0 723 962 B1, selected from the group consisting of

[1809] 3-(4-nitrobenzyl)-5-(3,4-dimethoxyphenyl)-6-ethyl-3,6-dihydro-1,3,4-thiadiazin-2-one;

[1810] 3-(4-aminobenzyl)-5-(3,4-dimethoxyphenyl)-6-ethyl-3,6-dihydro-1,3,4-thiadiazin-2-one;

[1811] 3-(4-trifluoroacetamidobenzyl)-5-(3,4-dimethoxyphenyl)-6-ethyl-3,6-dihydro-1,3,4-thiadiazin-2-one;

[1812] 3-(4-acetamidobenzyl)-5-(3,4-dimethoxyphenyl)-3,6-dihydro-1,3,4-thiadiazin-2-one;

[1813] 3-(4-methoxybenzyl)-5-(3,4-dimethoxyphenyl)-6-ethyl-3,6-dihydro-1,3,4-thiadiazin-2-one;

[1814] 3-(2,6-dichlorobenzyl)-5-(3,4-dimethoxyphenyl)-6-ethyl-3,6-dihydro-1,3,4-thiadiazin-2-one;

[1815] c) compounds, disclosed in EP 0 763 534 A1, selected from the group consisting of

[1816] 3-4-picolinoylaminobenzyl)-5-(3,4-dimethoxyphenyl)-6-ethyl-3,6-dihydro-1,3,4-thiadiazin-2-one;

[1817] 3-4-picolinoylaminobenzyl)-5-(3,4-dimethoxyphenyl)-3,6-dihydro-1,3,4-thiadiazin-2-one;

[1818] 3-4-nicotinoylaminobenzyl)-5-(3,4-dimethoxyphenyl)-3,6-dihydro-1,3,4-thiadiazin-2-one;

[1819] 3-4-isonicotinoylaminobenzyl)-5-(3,4-dimethoxyphenyl)-3,6-dihydro-1,3,4-thiadiazin-2-one;

[1820] 3-4-nicotinoylaminobenzyl)-5-(3,4-dimethoxyphenyl)-6-ethyl-3,6-dihydro-1,3,4-oxadiazin-2-one;

[1821] 2-4-nicotinoylaminobenzyl)-6-(3,4-dimethoxyphenyl)-5-ethyl-2,3,4,5-tetrahydropyridazin-3-one;

[1822] d) Compounds, disclosed in EP 0 539 306 B1 selected from the group consisting of

[1823] 5-(3-methoxy-4-difluoromethoxyphenyl)-6-ethyl-3,6-dihydro-1,3,4-thiadiazin-2-one;

[1824] 5-(3-methoxy-4-difluoromethoxyphenyl)-3,6-dihydro-1,3,4-thiadiazin-2-one;

[1825] e) compounds, disclosed in EP 0 618 201 A1, selected from the group consisting of

[1826] 3-dimethylaminopropyl-5-(3,4-dimethoxyphenyl)-6-ethyl-3,6-dihydro-1,3,4-thiadiazinon-2-one;

[1827] 3-dimethylaminopropyl-5-(3,4-dimethoxyphenyl)-3,6-dihydro-1,3,4-thiadiazinon-2-one;

[1828] 3-dimethylaminoethyl-5-(3,4-dimethoxyphenyl)-6-ethyl-3,6-dihydro-1,3,4-thiadiazinon-2-one;

[1829] 3-piperidinopropyl-5-(3-methoxy-4-difluoromethoxyphenyl)-6-ethyl-3,6-dihydro-1,3,4-thiadiazinon-2-one;

[1830] 3-morpholinopropyl-5-(3-methoxy-4-difluoromethoxyphenyl)-6-ethyl-3,6-dihydro-1,3,4-thiadiazinon-2-one;

[1831] f) compounds, disclosed in DE 196 04 388 A1, selected from the group consisting of

[1832] 3-(N,N-diethylamino)propyl N-[4-(3,6-dihydro-5-(3,4-dimethoxyphenyl)-2-oxo-2H-1,3,4-thiadiazin-3-ylmethyl)phenyl]carbamate;

[1833] 3-(N,N-diethylamino)propyl N-[4-(3,6-dihydro-5-(3-ethoxy-4-methoxyphenyl)-2-oxo-2H-1,3,4-thiadiazin-3-ylmethyl)phenyl]carbamate;

[1834] 3-(N,N-diethylamino)propyl N-[4-(6-(3,4-dimethoxyphenyl)-3-oxo-2,3,4,5-tetrahydropyridazin-2-ylmethyl)phenyl]carbamate;

[1835] 3-(N,N-diethylamino)propyl N-[4-(6-(3-ethoxy-4-methoxyphenyl)-3-oxo-2,3,4,5-tetrahydropyridazin-2-ylmethyl)phenyl]carbamate;

[1836] N-[4-(6-(3-ethoxy-4-methoxyphenyl)-3-oxo-2,3,4,5-tetrahydropyridazin-2-ylmethyl)phenyl]-2-(4-methylpiperazino)acetamide;

[1837] N-[4-(6-(3-cyclopentyloxy-4-methoxyphenyl)-3-oxo-2,3,4,5-tetrahydropyridazin-2-ylmethyl)phenyl]-2-(4-methylpiperazino)acetamide;

[1838] N-[4-(3,6-dihydro-5-(3-ethoxy-4-methoxyphenyl)-2-oxo-2H-1,3,4-thiadiazin-3-ylmethyl)phenyl]-2-(4-methylpiperazino)acetamide;

[1839] and/or physiologically acceptable salts thereof for the preparation of a medicament for the treatment of osteoporosis, tumours, tumour metastases, atherosclerosis, rheumatoid arthritis, multiple sclerosis, diabetes mellitus, ulcerative collitis and AIDS. 

1-5. (cancelled).
 6. Method for the treatment of tumours and tumour metastases using compounds selected from the group consisting of a) compounds of the formula I, disclosed in EP 0 738 715 A2,

in which R¹ and R² are each, independently of one another, H or A, R³ and R⁴ are each, independently of one another, —OH, —OR¹⁰, —S—R¹⁰, —SO—R¹⁰, —SO₂—R¹⁰, Hal, methylenedioxy, —NO₂, —NH₂, —NHR¹⁰ or —NR¹⁰R¹¹, R⁵ is a phenyl radical which is unsubstituted or monosubstituted or disubstituted by R⁶ and/or R⁷, Q is absent or is alkylene having 1-6 carbon atoms, R⁵ and R⁷ are each, independently of one another, —NH₂, —NR⁸R⁹, —NHR¹⁰, —NR¹⁰R¹¹, —NO₂, Hal, —CN, —OA, —COOH or —COOA, R⁸ and R⁹ are each, independently of one another, H, acyl having 1-8 carbon atoms, which may be substituted by 1-5 F and/or Cl atoms, or are —COOA, —SO-A, —SO₂A, —CONH₂, —CONHA, —CONA₂, —CO—COOH, —CO—COOA, —CO—CONH₂, —CO—CONHA or —CO—CONA₂, A is alkyl having from 1 to 6 carbon atoms, which may be substituted by 1-5 F and/or Cl atoms, R¹⁰ and R¹¹ are each, independently of one another, A, cycloalkyl having 3-7 carbon atoms, methylenecycloalkyl having 4-8 carbon atoms or alkenyl having 2-8 carbon atoms, and Hal is F, Cl, Br or l, b) compounds of the formula I, disclosed in EP 0 723 962 B1,

in which R¹and R² are each, independently of one another, H or A, R³ and R⁴ are each, independently of one another, —OH, —OR¹⁰, —S—R¹⁰, —SO—R¹⁰, —SO₂—R¹⁰, Hal, methylenedioxy, —NO₂, —NH₂, —NH¹⁰R¹¹, R⁵ is a phenyl radical which is unsubstituted or monosubstituted or disubstituted by R⁶ and/or R⁷, Q is absent or is alkylene having 1-6 carbon atoms, R⁶ and R⁷ are each, independently of one another, —NH₂, —NR⁸R⁹, —NHR¹⁰, —NR¹⁰R¹¹, —NO₂, Hal, —CN, —OA, —COOH or —COOA, R⁸ and R⁹ are each, independently of one another, H, acyl having 1-8 carbon atoms, which may be substituted by 1-5 F and/or Cl atoms, or are —COOA, —SO-A, —SO₂A, —CONH₂, —CONHA, —CONA₂, —CO—COOH, —CO—COOA, —CO—CONH₂, —CO—CONHA or —CO—CONA₂, A is alkyl having from 1 to 6 carbon atoms, which may be substituted by 1-5 F and/or Cl atoms, R¹⁰ and R¹¹ are each, independently of one another, A, cycloalkyl having 3-7 carbon atoms, methylenecycloalkyl having 4-8 carbon atoms or alkenyl having 2-8 carbon atoms, and Hal is F, Cl, Br or l, c) compounds of the formula I, disclosed in EP 0 763 534 A1,

in which B is an aromatic heterocyclic radical having from 1 to 4 N, O and/or S atoms, bonded via N or C, which may be unsubstituted or monosubstituted, disubstituted or trisubstituted by Hal, A and/or OA, and may also be fused to a benzene or pyridine ring, Q is absent or is alkylene having 1-6 carbon atoms, X is CH₂, S or O, R¹ and R² are each, independently of one another, H or A, R³ and R⁴ are each, independently of one another, —OH, —OR⁵, —S—R⁵, —SO—R⁵, —SO₂—R⁵, Hal, methylenedioxy, —NO₂, —NH₂, —NHR⁵ or —NR⁵R⁶, R⁵ and R⁶ are each, independently of one another, A, cycloalkyl having 3-7 carbon atoms, methylenecycloalkyl having 4-8 carbon atoms or alkenyl having 2-8 carbon atoms, A is alkyl having from 1 to 10 carbon atoms, which may be substituted by from 1 to 5 F and/or Cl atoms, and Hal is F, Cl, Br or l, d) compounds of the formula I, disclosed in EP 0 539 806 B1,

in which R¹ and R² are each, independently of one another, H or A, R³ is H, OA or O—C_(m)H_(2m+1−n)X_(n), R⁴ is —O—C_(m)H_(2m+1−n)X_(n), X is F or Cl, A is alkyl having 1-6 carbon atoms, m is 1, 2, 3, 4, 5 or 6, and n is 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12 or 13, e) compounds of the formula I, disclosed in EP 0 618 201 A1,

in which R¹ and R² are each, independently of one another, H or A, R³ and R⁴ are each, independently of one another, OH, OA, SA, SOA, SO₂A, Hal, methylenedioxy, cycloalkoxy having 3-7 carbon atoms or O—C_(m)H_(2m+1−k)F_(k), R⁵ is —NR⁶R⁷ or

where one CH₂ group may also be replaced by oxygen, R⁶ and R⁷ are each, independently of one another, H or A, Q is alkylene having 1-6 carbon atoms, A is alkyl having 1-6 carbon atoms, Hal is F, Cl, Br or l, m is 1, 2, 3, 4, 5 or 6, n is 3, 4, 5 or 6, k is 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12 or 13, f) compounds of the formula I, disclosed in DE 196 04 388 A1,

in which R¹ and R² are each, independently of one another, H or A, R³ and R⁴ are each, independently of one another, —OH, —OA, —S-A, —SO-A, —SO₂-A, Hal, methylenedioxy, —NO₂, —NH₂, —NHA or —NAA′, A and A′ are each, independently of one another, alkyl having from 1 to 10 carbon atoms, which may be substituted by from 1 to 5 F and/or Cl atoms, or are cycloalkyl having 3-7 carbon atoms or methylenecycloalkyl having 4-8 carbon atoms, B is —Y—R⁵ or —O—Y—R⁵, Q is absent or is alkylene having 1-4 carbon atoms, Y is absent or is alkylene having 1-10 carbon atoms, X is CH₂ or S, R⁵ is NH₂, NHA, NAA′ or a saturated 3-8-membered heterocyclic radical having at least one N atom which is unsubstituted or monosubstituted by A or OH and in which, in addition, further CH₂ groups may be replaced by NH, NA, S or O, Hal is F, Cl, Br or l, and physiologically acceptable salts thereof.
 7. Method for the treatment of osteoporosis, atherosclerosis, rheumatoid arthritis, multiple sclerosis, diabetes mellitus, ulcerative colitis and AIDS using compounds selected from the group consisting of a) compounds of the formula I, disclosed in EP 0 539 806 B1,

in which R¹ and R² are each, independently of one another, H or A, R³ is H, OA or O—C_(m)H_(2m+1−n)X_(n), R⁴ is —O—C_(m)H_(2m+1−n)X_(n), X is F or Cl, A is alkyl having 1-6 carbon atoms, m is 1, 2, 3, 4, 5 or 6, and n is 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12 or 13, b) compounds of the formula I, disclosed in EP 0 618 201 A1,

in which R¹ and R² are each, independently of one another, H or A, R³ and R⁴ are each, independently of one another, OH, OA, SA, SOA, SO₂A, Hal, methylenedioxy, cycloalkoxy having 3-7 carbon atoms or O—C_(m)H_(2m+1−k)F_(k), R⁵ is —NR⁶R⁷ or

where one CH₂ group may also be replaced by oxygen, R⁶ and R⁷ are each, independently of one another, H or A, Q is alkylene having 1-6 carbon atoms, A is alkyl having 1-6 carbon atoms, Hal is F, Cl, Br or l, m is 1, 2, 3, 4, 5 or 6, n is 3, 4, 5 or 6, k is 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12 or 13, and physiologically acceptable salts thereof.
 8. Method according to claim 6 using compounds selected from the group consisting of a) compounds, disclosed in EP 0 738 715 A2, being 2-(4-ethoxycarbonylaminobenzyl)-6-(3,4-dimethoxyphenyl)-2,3,4,5-tetrahydropyridazin-3-one; 2-(3-methylsulfonamidobenzyl)-6-(3,4-dimethoxyphenyl)-2,3,4,5-tetrahydropyridazin-3-one; 2-(3-acetamidobenzyl)-6-(3,4-dimethoxyphenyl)-2,3,4,5-tetrahydropyridazin-3-one; 2-(4-trifluoroacetamidobenzyl)-6-(3,4-dimethoxyphenyl)-5-ethyl-2,3,4,5-tetrahydropyridazin-3-one; 2-(4-ethoxycarbonylaminobenzyl)-6-(3,4-dimethoxyphenyl)-5-ethyl-2,3,4,5-tetrahydropyridazin-3-one; 2-(4-methoxycarbonylaminobenzyl)-6-(3,4-dimethoxyphenyl)-5-ethyl-2,3,4,5-tetrahydropyridazin-3-one; 2-(4-butyrylaminobenzyl)-6-(3,4-dimethoxyphenyl)-5-ethyl-2,3,4,5-tetrahydropyridazin-3-one; b) compounds, disclosed in EP 0 723 962 B1, being 3-(4-nitrobenzyl)-5-(3,4-dimethoxyphenyl)-6-ethyl-3,6-dihydro-1,3,4-thiadiazin-2-one; 3-(4-aminobenzyl)-5-(3,4-dimethoxyphenyl)-6-ethyl-3,6-dihydro-1,3,4-thiadiazin-2-one; 3-(4-trifluoroacetamidobenzyl)-5-(3,4-dimethoxyphenyl)-6-ethyl-3,6-dihydro-1,3,4-thiadiazin-2-one; 3-(4-acetamidobenzyl)-5-(3,4-dimethoxyphenyl)-3,6-dihydro-1,3,4-thiadiazin-2-one; 3-(4-methoxybenzyl)-5-(3,4-dimethoxyphenyl)-6-ethyl-3,6-dihydro-1,3,4-thiadiazin-2-one; 3-(2,6-dichlorobenzyl)-5-(3,4-dimethoxyphenyl)-6-ethyl-3,6-dihydro-1,3,4-thiadiazin-2-one; c) compounds, disclosed in EP 0 763 534 A1, being 3-(4-picolinoylaminobenzyl)-5-(3,4-dimethoxyphenyl)-6-ethyl-3,6-dihydro-1,3,4-thiadiazin-2-one; 3-(4-picolinoylaminobenzyl)-5-(3,4-dimethoxyphenyl)-3,6-dihydro-1,3,4-thiadiazin-2-one; 3-(4-nicotinoylaminobenzyl)-5-(3,4-dimethoxyphenyl)-3,6-dihydro-1,3,4-thiadiazin-2-one; 3-(4-isonicotinoylaminobenzyl)-5-(3,4-dimethoxyphenyl)-3,6-dihydro-1,3,4-thiadiazin-2-one; 3-(4-nicotinoylaminobenzyl)-5-(3,4-dimethoxyphenyl)-6-ethyl-3,6-dihydro-1,3,4-oxadiazin-2-one; 2-(4-nicotinoylaminobenzyl)-6-(3,4-dimethoxyphenyl)-5-ethyl-2,3,4,5-tetrahydropyridazin-3-one; d) compounds, disclosed in EP 0 539 806 B1, being 5-(3-methoxy-4-difluoromethoxyphenyl)-6-ethyl-3,6-dihydro-1,3,4-thiadiazin-2-one; 5-(3-methoxy-4-difluoromethoxyphenyl)-3,6-dihydro-1,3,4-thiadiazin-2-one; e) compounds, disclosed in EP 0 618 201 A1, being 3-dimethylaminopropyl-5-(3,4-dimethoxyphenyl)-6-ethyl-3,6-dihydro-1,3,4-thiadiazinon-2-one; 3-dimethylaminopropyl-5-(3,4-dimethoxyphenyl)-3,6-dihydro-1,3,4-thiadiazinon-2-one; 3-dimethylaminoethyl-5-(3,4-dimethoxyphenyl)-6-ethyl-3,6-dihydro-1,3,4-thiadiazinon-2-one; 3-piperidinopropyl-5-(3-methoxy-4-difluoromethoxyphenyl)-6-ethyl-3,6-dihydro-1,3,4-thiadiazinon-2-one; 3-morpholinopropyl-5-(3-methoxy-4-difluoromethoxyphenyl)-6-ethyl-3,6-dihydro-1,3,4-thiadiazinon-2-one; f) compounds, disclosed in DE 196 04 388 A1, being 3-(N,N-diethylamino)propyl N-[4-(3,6-dihydro-5-(3,4-dimethoxyphenyl)-2-oxo-2H-1,3,4-thiadiazin-3-ylmethyl)phenyl]carbamate; 3-(N,N-diethylamino)propyl N-[4-(3,6-dihydro-5-(3-ethoxy-4-methoxyphenyl)-2-oxo-2H-1,3,4-thiadiazin-3-ylmethyl)phenyl]carbamate; 3-(N,N-diethylamino)propyl N-[4-(6-(3,4-dimethoxyphenyl)-3-oxo-2,3,4,5-tetrahydropyridazin-2-ylmethyl)phenyl]carbamate; 3-(N,N-diethylamino)propyl N-[4-(6-(3-ethoxy-4-methoxyphenyl)-3-oxo-2,3,4,5-tetrahydropyridazin-2-ylmethyl)phenyl]carbamate; N-[4-(6-(3-ethoxy-4-methoxyphenyl)-3-oxo-2,3,4,5-tetrahydropyridazin-2-ylmethyl)phenyl]-2-(4-methylpiperazino)acetamide; N-[4-(6-(3-cyclopentyloxy-4-methoxyphenyl)-3-oxo-2,3,4,5-tetrahydropyridazin-2-ylmethyl)phenyl]-2-(4-methylpiperazino)acetamide; N-[4-(3,6-dihydro-5-(3-ethoxy-4-methoxyphenyl)-2-oxo-2H-1,3,4-thiadiazin-3-ylmethyl)phenyl]-2-(4-methylpiperazino)acetamide; and physiologically acceptable salts thereof.
 9. Method according to claim 7 using compounds selected from the group consisting of a) compounds, disclosed in EP 0 539 806 B1, being 5-(3-methoxy-4-difluoromethoxyphenyl)-6-ethyl-3,6-dihydro-1,3,4-thiadiazin-2-one; 5-(3-methoxy-4-difluoromethoxyphenyl)-3,6-dihydro-1,3,4-thiadiazin-2-one; b) compounds, disclosed in EP 0 618 201 A1, being 3-dimethylaminopropyl-5-(3,4-dimethoxyphenyl)-6-ethyl-3,6-dihydro-1,3,4-thiadiazinon-2-one; 3-dimethylaminopropyl-5-(3,4-dimethoxyphenyl)-3,6-dihydro-1,3,4-thiadiazinon-2-one; 3-dimethylaminoethyl-5-(3,4-dimethoxyphenyl)-6-ethyl-3,6-dihydro-1,3,4-thiadiazinon-2-one; 3-piperidinopropyl-5-(3-methoxy-4-difluoromethoxyphenyl)-6-ethyl-3,6-dihydro-1,3,4-thiadiazinon-2-one; 3-morpholinopropyl-5-(3-methoxy-4-difluoromethoxyphenyl)-6-ethyl-3,6-dihydro-1,3,4-thiadiazinon-2-one; and physiologically acceptable salts thereof.
 10. Method according to claim 6 for the treatment of neoplastic damage.
 11. Method according to claim 6 for the treatment of pre-cancerogenic damage.
 12. Method according to claim 6 for regulating apoptosis in human cells.
 13. Method according to claim 7 for the treatment of neoplastic damage.
 14. Method according to claim 7 for the treatment of pre-cancerogenic damage.
 15. Method according to claim 7 for regulating apoptosis in human cells. 